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Method for preparing novel photonic cooling gel

A cold gel and photon technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as skin redness, skin abnormalities, and skin brittleness, and achieve short swelling time, good curing, and pro- good skin performance

Inactive Publication Date: 2017-08-11
岳阳市阿罗格医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the commonly used hormonal drugs on the market can easily cause "skin abnormalities" such as redness, itching, dryness, acne, purple lines, and brittle skin after use, but it is difficult for us to find out the reason

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of a novel photonic cold gel, comprising the following steps:

[0024] Mix 1 part of carbomer and 30 parts of glycerin and stir evenly, add 70 parts of water, stir and swell for 30 minutes, then add 0.05 parts of ethyl p-hydroxybenzoate, continue stirring for 1 hour, and finally add 0.5 parts of hydroxyl-terminated polysiloxane and stir Afterwards, the temperature was raised to 70-80°C, and 0.01 parts of aminoacetic acid and 0.003 parts of methyltriethoxysilane were added, reacted for 1 hour, 0.1 parts of nano-hydroxyapatite were added, and 0.007 parts of methyltriethoxysilane was added, Continue the reaction for 1 hour, cool to room temperature after the reaction, add 30 parts of water to the reaction system, and stir and mix for 30 minutes at a speed of 20 r / min to obtain the product.

Embodiment 2

[0026] A preparation method of a novel photonic cold gel, comprising the following steps:

[0027] Mix and stir 3 parts of carbomer and 60 parts of glycerin evenly, add 133 parts of water, stir and swell for 50 minutes, then add 0.5 parts of ethyl p-hydroxybenzoate, continue stirring for 2 hours, and finally add 0.8 parts of hydroxyl-terminated polysiloxane After stirring, heat up to 70-80°C, add 0.02 parts of glycine and 0.007 parts of triethoxysilane, react for 2 hours, add 0.3 parts of nano-hydroxyapatite, and add 0.013 parts of triethoxysilane, continue the reaction for 3 hours, After the reaction is completed, cool to room temperature, add 67 parts of water to the reaction system, and stir and mix for 60 minutes at a speed of 50 r / min to obtain the product.

Embodiment 3

[0029] A preparation method of a novel photonic cold gel, comprising the following steps:

[0030] Mix and stir 1.5 parts of carbomer and 35 parts of glycerin evenly, add 80 parts of water, stir and swell for 35 minutes, then add 0.1 parts of ethyl p-hydroxybenzoate, continue stirring for 1.2 hours, and finally add 0.6 parts of hydroxyl-terminated polysiloxane After the alkane is stirred, the temperature is raised to 70-80°C, and 0.012 parts of aminoacetic acid and 0.004 parts of 1 / 3 vinyl triethoxysilane are added, reacted for 1.2 hours, 0.15 parts of nano-hydroxyapatite are added, and 0.008 parts of vinyl triethoxysilane are added. Ethoxysilane, continue to react for 1.5h, cool to room temperature after the reaction, add 40 parts of water to the reaction system, stir and mix at 30r / min for 40min to obtain the product.

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Abstract

The invention discloses a method for preparing novel photonic cooling gel. The method specifically comprises the following steps: uniformly mixing and stirring Carbomer and glycerin, adding 2 / 3 of water, stirring and swelling for 30-50 minutes; adding ethyl p-hydroxybenzoate, further stirring for 1-2 hours, finally adding an organo-siloxane monomer for stirring, heating to the temperature of 70-80 DEG C, adding a catalyst and 1 / 3 of a cross-linking agent, reacting for 1-2 hours, adding nano-hydroxyapatite, adding the residual cross-linking agent, further reacting for 1-3 hours, cooling to room temperature after the reaction is ended, adding the residual water into the reaction system, stirring and mixing for 30-60 minutes at the rotating speed of 20-50 revolutions per minute, thereby obtaining the product. The photonic cooling gel prepared by the method is stable in quality, capable of insulating heat and guiding light and high in skin-friendly property and has a good effect of immobilizing skin keratinocytes.

Description

[0001] Technical field: [0002] The invention relates to the field of biomedical materials, in particular to a preparation method of a novel photonic cold gel. [0003] Background technique: [0004] The outermost layer of the skin, called the stratum corneum, is made up of 20 layers of flat, interwoven horny cells. Keratinocytes are as tough as "bricks", and there are lipids like "mortar" that tightly connect keratinocytes to each other to form a "brick wall structure". There is also a protective film (water Fatty film), together constitute the skin barrier. The skin barrier can lock skin moisture and oil, and resist the invasion of various skin surface bacteria, which plays a very important role in protecting human health. [0005] However, with the deterioration of the outdoor and indoor environment, the skin surface is often severely damaged, such as: skin redness, itching, dryness, acne, purple lines, skin becomes brittle, etc. The skin surface loses its normal protect...

Claims

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Application Information

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IPC IPC(8): A61K8/892A61K8/81A61K8/37A61K8/04A61K8/24A61K8/34A61Q17/00
CPCA61K8/892A61K8/042A61K8/24A61K8/345A61K8/37A61K8/8147A61Q17/00A61Q17/005
Inventor 苏亚城赵志豪
Owner 岳阳市阿罗格医药技术有限公司
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