Portable physiological index detector based on micro fluidic paper chip and detection method thereof

A technology of microfluidic paper chips and physiological indicators, which is applied in the fields of biological science and medical engineering, can solve problems such as measurement errors, and achieve the effect of ingenious conception, humanized design and reliable results

Inactive Publication Date: 2017-08-15
刘锦
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide a portable physiological index detector and its detection method based on the microfluidic paper chip, which effectively solves the problem of using the microfluidic paper chip to detect the physiological index. error problem

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  • Portable physiological index detector based on micro fluidic paper chip and detection method thereof
  • Portable physiological index detector based on micro fluidic paper chip and detection method thereof
  • Portable physiological index detector based on micro fluidic paper chip and detection method thereof

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Embodiment 1

[0027] Embodiment 1, a portable physiological index detector based on a microfluidic paper chip and its detection method, including samples of physiological indexes to be measured, which can be blood sugar, uric acid, etc., and put an appropriate amount into a microfluidic paper chip. The paper chip uses a screen-printed carbon electrode uric acid sensor chip to detect the concentration of uric acid. After continuous improvement and testing, it is a low-cost, convenient, fast, high-precision, portable and easy-to-operate paper chip. The front-end special interface collects the weak analog voltage signal, and the weak analog voltage signal enters the voltage follower module for buffering, isolation, and improves the load capacity, and then through the voltage amplifier module, it is amplified in the same phase and sent to the A / D conversion module The analog electrical signal is converted into a digital electrical signal, the single-chip microcomputer module receives the digital...

Embodiment 2

[0035] Embodiment 2, on the basis of Embodiment 1, the voltage follower module is used to buffer, isolate, and improve the effect of carrying capacity, thereby improving the accuracy of measurement, including the operational amplifier U1 whose model is OPA656U, the operational amplifier Pin 3 of U1 is the non-inverting input terminal connected to the electrochemical signal generated by the microfluidic paper chip after the grounding resistor R1 eliminates the signal, because according to the virtual short and virtual break characteristics of the operational amplifier, if the internal resistance of the electrochemical signal is very Large, that is, the ability to carry the load is very poor, the reflected current signal will form a strong emission oscillation near the input point, that is, "echo" after the noise is amplified, the output signal quality will be very poor, the operational amplifier U1 Pin 2 is the non-inverting input terminal directly connected to the pin 6 output ...

Embodiment 3

[0036] Embodiment 3, on the basis of Embodiment 1, the voltage amplifier module is used to amplify the voltage signal output by the voltage follower module in equal proportions and send it to the A / D conversion module, including a model OPA8431D operational amplifier U2, an operational amplifier Pin 3 of U2 is the voltage signal output by connecting the non-inverting input terminal to pin 6 of the operational amplifier U1 through the resistor R3, and pin 2 of the operational amplifier U2 is respectively connected to one end of the grounding resistor R2, one end of the resistor R4, and the other end of the resistor R4 Connect to pin 6 of operational amplifier U2 respectively, resistor R3 and resistor R4 form the feedback proportional coefficient, voltage magnification = 1+R4 / R2, in this example, according to the relationship between uric acid concentration and potential, set the resistance values ​​of resistor R2 and resistor R4 to 46KΩ , 20KΩ, the amplified voltage signal at th...

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Abstract

The invention relates to a portable physiological index detector based on a micro fluidic paper chip and a detection method thereof. The portable physiological index detector comprises a detected physiological index sample, a micro fluidic paper chip, a voltage follower module, a voltage amplifier module, an A / D transition module, and a single-chip microcomputer module which are connected in order, the single-chip microcomputer module is respectively connected with a button module, a display module and a voice module, which can effectively solves the problems of measurement error due to detection of the physiological index by the micro fluidic paper chip. The portable physiological index detector has the advantages of ingenious conception, humanized design and easy carrying, the novel micro fluidic paper chip is used for detecting the uric acid concentration, a potential signal generated after a biochemical reaction is subjected to voltage following, voltage amplification, and AD transition to a digital electric signal, the digital electric signal is sent to a STM32-series single-chip microcomputer or intelligent analysis and processing, detection result can be rapidly obtained and displayed on a screen, relative high concentration, relative low concentration or normal measurement result can be prompted by the system by comparing with a health standard, and the portable physiological index detector has market development potential.

Description

technical field [0001] The invention relates to the fields of biological science and medical engineering, in particular to a portable physiological index detector based on a microfluidic paper chip and a detection method thereof. Background technique [0002] Microfluidic paper chip technology integrates the basic operation units such as sample preparation, reaction, separation, and detection in the process of biological, chemical, and medical analysis into a micron-scale chip, and automatically completes the whole process of analysis, that is, microfluidic paper chip It is a special kind of electrochemical biosensor. [0003] Electrochemical biosensors generally use conductive ions as the basic medium to convert target physiological signals into electrical or physical signals such as current and potential. Prospects. [0004] In the design of electrochemical sensors, according to the different measurement signals, they can be divided into current type, conductivity type, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00
CPCG01N35/00
Inventor 刘锦
Owner 刘锦
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