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Application of nadph in the preparation of anti-anxiety drugs

An anti-anxiety and drug technology, applied in the field of preparation of anti-anxiety drugs, can solve the problems of NADPH and other problems

Active Publication Date: 2020-06-23
山东蓝康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, there is no report on the use of NADPH in the treatment of anxiety disorders

Method used

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  • Application of nadph in the preparation of anti-anxiety drugs
  • Application of nadph in the preparation of anti-anxiety drugs
  • Application of nadph in the preparation of anti-anxiety drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of NADPH capsules

[0021] The composition of present embodiment NADPH capsule is: NADPH 20g, suspending agent microcrystalline cellulose 60g, preservative tert-butyl-4-hydroxyanisole 0.04g, lubricant magnesium stearate 2g, filler lactose added to 200g.

[0022] The preparation method comprises the following steps: respectively weighing the above prescription amount of NADPH and various pharmaceutical excipients, mixing uniformly, sieving through a 60-mesh sieve for three times, and packing into capsule shells to obtain the product.

experiment example 1

[0023] Experimental example Study on the Anxiety Effect of 1NADPH on Stress Anxiety Model Rats

[0024] 1. Purpose of the experiment

[0025] Investigating the anxiolytic effects of NADPH.

[0026] 2. Experimental method

[0027] 2.1 Experimental reagents and animals

[0028] NADPH, purchased from Biyuntian, with a purity of ≥97%; NADPH was dissolved in 0.9% normal saline, stored in a refrigerator at 4°C and protected from light, ready for immediate use;

[0029] 40 healthy male 3-month-old Sprague Dawley (SD) rats, weighing 250±15g, were provided by the Experimental Animal Center of Soochow University.

[0030] Animals were first adaptively fed for 1 week in an environment with light time 8:00AM-8:00PM, room temperature 22±2.5°C, and relative humidity 45%-55%, free to eat and drink, in order to reduce the impact of non-experimental factors on the results, The animals were petted several times a day to adapt to the experimenter's operation.

[0031] 2.2 Experimental gro...

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Abstract

The invention belongs to the field of drugs or health products and particularly relates to an application of NADPH in preparation of anti-anxiety drugs. The research finds that the NADPH is capable of significantly improving the exploration interest, significantly reducing the anxiety level of a rat and reversing anxiety behaviors caused by chronic stress. The results show that the NADPH has an anti-anxiety effect, and can be used as a potential drug for preventing or treating generalized anxiety disorder.

Description

technical field [0001] The invention belongs to the field of medicines or health care products, and in particular relates to the application of NADPH in the preparation of anti-anxiety medicines. Background technique [0002] Anxiety disorder is a neurosis characterized by recurrent episodes of acute anxiety, including six clinical manifestations such as generalized anxiety and episodic panic, often accompanied by dizziness, chest tightness, palpitations, dyspnea, dry mouth, frequent urination, Urinary urgency, sweating, tremor and restlessness in movement, sleep disturbance, etc., accompanied by autonomic dysfunction. Anxiety disorders not only directly affect people's quality of life and physical and mental health, but also cause other diseases, such as phobias, hypochondriacs, neurasthenia and other mental diseases. With the development of modern society, people's pace of life is generally accelerated, and people will face pressure from society, life and work, so the num...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7084A61P25/22
CPCA61K31/7084
Inventor 秦正红罗丽
Owner 山东蓝康药业有限公司
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