Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging

A nanoparticle, neural tissue technology that addresses the lack of binding and/or spectral properties in formulations, applications, analysis using fluorescence emission, etc. in vivo

Inactive Publication Date: 2017-10-13
MEMORIAL SLOAN KETTERING CANCER CENT +1
View PDF49 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, molecules such as distyrylbenzene and oxazines have been used but lack the binding and/or spe

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
  • Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
  • Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0067] Throughout the specification, where compositions are described as having, comprising, or comprising specified components, or where processes are described as having, comprising, or comprising specified steps, it is additionally contemplated that there are components consisting essentially of or consisting of the recited components The composition of the invention, and there are methods of the invention which consist essentially of or consist of the recited process steps.

[0068] It should be understood that the order of steps or order for performing certain actions is immaterial so long as the invention remains operable. Furthermore, two or more than two steps or actions may be performed simultaneously.

[0069] Reference herein to any publication in, for example, the Background section is not an admission that that publication serves as prior art with respect to any of the solutions presented herein. The Background section is presented for clarity and is not intended...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The average diameteraaaaaaaaaa
Login to view more

Abstract

Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.

Description

[0001] Related Application Cross Reference [0002] This application claims the benefit of U.S. Provisional Application Serial No. 62 / 092,191, filed December 15, 2014, which is hereby incorporated by reference in its entirety. [0003] governmental support [0004] This invention was made with government support under Grant No. NIH NCI U54 CA199081-01 awarded by the National Institute of Health. technical field [0005] The present invention generally relates to cyclic peptides to cyclic peptide-conjugated nanoparticles and methods of using said cyclic peptides and / or said cyclic peptide-conjugated nanoparticles for intraoperative neural tissue imaging. Background technique [0006] Many surgical procedures carry the risk of accidental nerve damage or transection, which can create a host of problems such as chronic pain or paralysis. The use of near-infrared (NIR) agents to highlight neural tissue during surgery has been investigated, thereby enhancing the surgeon's abi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/00A61B5/00A61K9/00
CPCA61B5/0071A61B5/4893A61K9/0014A61K9/0019A61K49/0032A61K49/0056A61K49/0065A61K49/0093
Inventor 米歇尔·S·布拉德伯里巴内·游乌尔里希·维斯纳陈培明马凯斯尼哈尔·G·帕特尔达尼埃拉·卡拉萨瓦·扎诺尼
Owner MEMORIAL SLOAN KETTERING CANCER CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap