Near-infrared fluorescent heptamethine cyanine dye and application thereof in preparation of tumor diagnosis agent and/ or imaging agent

Abstract

The invention provides a near-infrared fluorescent heptamethine cyanine dye and application thereof in preparation of a tumor diagnosis agent and / or an imaging agent. The near-infrared fluorescent heptamethine cyanine dye is a compound DZ-1, wherein the side chain of the compound DZ-1 is (CH2)4SO3H, so that the compound DZ-1 can be directly dissolved in water; in addition, the near-infrared fluorescent heptamethine cyanine dye can be applied by intravenous injection during living imaging, thus achieving the same treatment and applying mode as clinic ICG (Indocyanine Green); the compound DZ-1 can be specifically absorbed by hepatoma carcinoma cell and is gathered at the tumor part to support no-intrusive NIRF imaging, so that the tumor growing part can be detected; the fluorescence intensity at the tumor part, the specificity and the targeting performance are prior to those of clinically-used ICG. Therefore, the tumor diagnosis agent and / or the imaging agent adopting the compound DZ-1 are high in tumor targeting performance and high in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and relates to a near-infrared fluorescent heptamethine dye and its application in the preparation of tumor diagnostic reagents and / or imaging reagents. Background technique [0002] The rapid development of molecular imaging technology has advanced the diagnosis of tumors from the traditional anatomical form to the molecular level of function, metabolism, and even receptors and genes. Among them, fluorescence imaging technology can detect tumors in a timely and accurate manner, continuously and non-invasively observe changes in tumors, has the advantages of fast detection time (up to 1 second), and does not need to inject substrates. It has become a hot spot in the field of tumor diagnosis and treatment research. Studies have found that the closer the fluorescence wavelength is to 900nm, the stronger the penetration ability. Therefore, near-infrared fluorescence (NIRF) with both abs...

AI Technical Summary

Problems solved by technology

Since targeting fragments can only detect partially specific tumor cells, and chemical conjugation may alter the avidity of target molecules, it is necessary to develop novel NIRF dyes that are simple and can be directly used for non-invasive tumor imaging.

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