A kind of memantine hydrochloride sustained-release capsule composition

A technology of memantine hydrochloride and sustained-release capsules, which is applied in the direction of drug combination, microcapsules, capsule delivery, etc., can solve the problems of high cost, complicated preparation process, and long time consumption, and achieve reduction of toxic and side effects, small size, and improvement of drug efficacy Effect

Active Publication Date: 2020-09-01
HAINAN HERUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above technologies avoid the problem of drug burst release to a certain extent, but the preparation process is complicated, time-consuming and costly

Method used

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  • A kind of memantine hydrochloride sustained-release capsule composition
  • A kind of memantine hydrochloride sustained-release capsule composition
  • A kind of memantine hydrochloride sustained-release capsule composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Prepare 1000 memantine hydrochloride sustained-release capsules (with memantine hydrochloride 28mg / grain), the used raw material composition weight ratio is as follows:

[0039] (1) Drug composite layer formula

[0040]

[0041] (2) Sustained-release coating layer formula

[0042]

[0043]

[0044] (3) Preparation method

[0045] ①First crush memantine hydrochloride to a particle size of D with a jet mill 90 8 μm, to obtain micronized memantine hydrochloride;

[0046] ② Preparation of drug-containing coating solution: According to the prescription, take Eudragit NE 30D dissolved in ethanol to prepare solution A; dissolve triethyl citrate and memantine hydrochloride in ethanol to prepare solution B; dissolve vitamin E in ethanol to prepare solution B; For solution C, add solutions A and C to solution B, stir, and disperse evenly to obtain a drug-containing coating solution. The drug-containing coating solution is passed through an 80-mesh sieve, kept stirrin...

Embodiment 2

[0052] Prepare 1000 memantine hydrochloride sustained-release capsules (with memantine hydrochloride 28mg / grain), the used raw material composition weight ratio is as follows:

[0053] (1) Drug composite layer formula

[0054]

[0055] (2) Sustained-release coating layer formula

[0056]

[0057]

[0058] (3) Preparation method

[0059] ①First crush memantine hydrochloride to a particle size of D with a jet mill 90 8 μm, to obtain micronized memantine hydrochloride;

[0060] ② Preparation of drug-containing coating solution: According to the prescription, take Eudragit NE 30D dissolved in ethanol to prepare solution A; dissolve triethyl citrate and memantine hydrochloride in ethanol to prepare solution B; dissolve vitamin E in ethanol to prepare solution B; For solution C, add solutions A and C to solution B, stir, and disperse evenly to obtain a drug-containing coating solution. The drug-containing coating solution is passed through an 80-mesh sieve, kept stirrin...

Embodiment 3

[0066] Prepare 1000 memantine hydrochloride sustained-release capsules (with memantine hydrochloride 28mg / grain), the used raw material composition weight ratio is as follows:

[0067] (1) Drug composite layer formula

[0068]

[0069] (2) Sustained-release coating layer formula

[0070]

[0071]

[0072] (3) Preparation method

[0073] ①First crush memantine hydrochloride to a particle size of D with a jet mill 90 5 μm, to obtain micronized memantine hydrochloride;

[0074] ② Preparation of drug-containing coating solution: According to the prescription, take Eudragit NE 30D dissolved in ethanol to prepare solution A; dissolve triethyl citrate and memantine hydrochloride in ethanol to prepare solution B; dissolve vitamin E in ethanol to prepare solution B; For solution C, add solutions A and C to solution B, stir, and disperse evenly to obtain a drug-containing coating solution. The drug-containing coating solution is passed through an 80-mesh sieve, kept stirrin...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a memantine hydrochloride sustained-release capsule composition, which is prepared by filling with sustained-release pills containing memantine hydrochloride, wherein the sustained-release pills comprise a blank pill core, a drug composite layer and a sustained-release coating layer, and a weight ratio of memantine hydrochloride to vitamin E in the drug composite layer is 1:1-1:8, preferably 1:3-1:5. According to the present invention, memantine hydrochloride and vitamin E provide a synergistic effect so as to improve the treatment effect of the product; and through the co-action of the memantine hydrochloride, the vitamin E and the sustained-release skeleton, the stability of the drug is enhanced, it is ensured that the sudden release of the drug cannot be generated, the drug can be continuously, uniformly and slowly released, the blood drug level can be controlled within the effective blood drug level range, the toxic-side effect of the drug is reduced, and the compliance of the patient is improved.

Description

technical field [0001] The invention discloses a medicine for resisting Alzheimer's type senile dementia, in particular to a memantine hydrochloride slow-release capsule composition, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Dementia, also known as Alzheimer's disease (AD), is an irreversible progressive disorder of brain cell (neuron) deterioration that results in loss of cognitive function, primary memory, judgment and reasoning, motor coordination and pattern recognition . In advanced stages of the disease, all memory and intellectual function may be lost. The incidence of AD in my country is about 1%. It is estimated that there are as many as 5 million AD patients among the elderly over 60 years old in my country. The incidence rate over 65 years old is 3% to 5%, and it is increasing year by year. [0003] The drugs currently used to treat Alzheimer's disease mainly include acetylcholinesterase inhibitors, brain ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/62A61K31/13A61K31/355A61K47/38A61K47/10A61K47/32A61P25/28
CPCA61K9/0002A61K9/5031A61K9/5042A61K9/5078A61K31/13A61K31/355A61K2300/00
Inventor钟正明
OwnerHAINAN HERUI PHARMA