A kind of pharmaceutical composition for treating acute ischemic stroke

A technology for ischemic stroke and composition, which is applied in the field of medicine and can solve the problems of narrow thrombolysis time window, lack of rapid thrombolysis effect of traditional Chinese medicine and single drugs, etc.

Inactive Publication Date: 2018-07-13
张惊宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Due to the many contraindications of the above-mentioned thrombolytic drugs, and the narrow time window for thrombolysis, traditional Chinese medicine and single drugs lack rapid thrombolytic effect

Method used

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  • A kind of pharmaceutical composition for treating acute ischemic stroke
  • A kind of pharmaceutical composition for treating acute ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Pharmaceutical composition for treating acute ischemic stroke and its preparation

[0039] Prescription: batroxobin 3500mg, citicoline 1000mg, ginkgolide B 600mg, protoporphyrin sodium 60mg.

[0040] Preparation:

[0041] 1) Take the prescription amount of citicoline and protoporphyrin sodium and mix them with sterile water for injection to dissolve to obtain solution A, the solution concentration is calculated as 5 mg / ml based on citicoline;

[0042] 2) Take the prescribed amount of batroxobin, add sterile water for injection, 35000mg phosphoric acid, 105000mg L-arginine, 14000mg mannitol, 350mg Tween 80 and stir to dissolve, add the prescribed amount of ginkgolide B and stir to dissolve again to obtain solution B , the solution concentration is calculated as 2 mg / ml with batroxobin;

[0043] 3) Mix solution A and solution B, filter through a microporous membrane with a pore size of 0.45 μm, divide the filtrate into 40 ml sterilized vials, each bottle conta...

Embodiment 2

[0044] Example 2 Pharmaceutical composition for treating acute ischemic stroke and its preparation

[0045] Prescription: batroxobin 4000mg, citicoline 1500mg, ginkgolide B 900mg, protoporphyrin sodium 62mg.

[0046] Preparation:

[0047] 1) Take the prescription amount of citicoline and protoporphyrin sodium and mix them with sterile water for injection to dissolve to obtain solution A, the solution concentration is calculated as 5 mg / ml based on citicoline;

[0048] 2) Take the prescribed amount of batroxobin, add sterilized water for injection, 40000mg phosphoric acid, 120000mg L-arginine, 16000mg mannitol, 400mg Tween 80 and stir to dissolve, add the prescribed amount of ginkgolide B and stir to dissolve again to obtain solution B , the solution concentration is calculated as 2 mg / ml with batroxobin;

[0049] 3) Mix solution A with solution B, filter through a microporous membrane with a pore size of 0.45 μm, divide the filtrate into 40 ml sterilized vials, each bottle c...

Embodiment 3

[0050] Example 3 Pharmaceutical composition for treating acute ischemic stroke and its preparation

[0051] Prescription: batroxobin 6000mg, citicoline 3000mg, ginkgolide B 2800mg, protoporphyrin sodium 70mg.

[0052] Preparation:

[0053] 1) Take the prescription amount of citicoline and protoporphyrin sodium and mix them with sterile water for injection to dissolve to obtain solution A, the solution concentration is calculated as 5 mg / ml based on citicoline;

[0054] 2) Take the prescribed amount of batroxobin, add sterilized water for injection, 60000mg phosphoric acid, 180000mg L-arginine, 24000mg mannitol, 600mg Tween 80 and stir to dissolve, add the prescribed amount of ginkgolide B and stir to dissolve again to obtain solution B , the solution concentration is calculated as 2 mg / ml with batroxobin;

[0055] 3) Mix solution A and solution B, filter through a microporous membrane with a pore size of 0.45 μm, divide the filtrate into 40 ml sterilized vials, each bottle c...

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Abstract

The invention belongs to the field of medicines, and particularly relates to a medicinal composition for treating acute cerebral ischemic stroke. The medicinal composition is prepared from pharmaceutically acceptable medicinal auxiliary materials, batroxobin, citicoline, ginkgolide and protoporphyrin sodium. The dosage form of the medicinal composition is preferably lyophilized powder for injection. The protoporphyrin sodium in the medicinal composition has a significant effect of enhancing the batroxobin functions of preventing thrombosis and improving cerebral blood perfusion, so that improvement on the cerebral ischemic stroke treating effect of the batroxobin is benefited.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pharmaceutical composition for treating acute ischemic stroke. Background technique [0002] Ischemic stroke (Cerebral ischemic stroke) is a brain blood circulation disorder that leads to local blood supply and inflammation, resulting in brain tissue necrosis and neurological impairment, usually caused by stenosis or thromboembolism in brain blood vessels. Ischemic stroke accounts for more than 85% of strokes, and is currently the most lethal and disabling disease. Post-stroke hemiplegia and loss of mobility are the main problems that plague the majority of patients. [0003] Acute ischemic stroke (Acute cerebral arterial thrombosis) is the main type of ischemic stroke, accounting for about 60-80% of the total number of stroke patients. There are approximately 1.5 to 2 million new patients with acute ischemic stroke in China every year. The case fatality rate is about 80-120 / 100,000 p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61K9/19A61P9/10A61K31/7068A61K31/365A61K31/409
CPCA61K9/19A61K31/365A61K31/409A61K31/7068A61K38/4806A61K2300/00
Inventor 张惊宇谢芳萍张力娜
Owner 张惊宇
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