86 results about "Injectable Lyophilized Powder" patented technology

Disclosed is the use of paeonol in preparing medicament for the prevention or treatment of fatty liver, and also the use of medicinal combination preparation of paeonol with medicinal carrying agent in preparing medicaments for the prevention and treatment of fatty liver disease, the dose forms of the medicament include soft capsules, drop pills, pills, powders, tablets, capsules, granules, injections, fluid infusions, freeze-dried powders for injection, suppositories, film agents, tiny capsules, tincture, syrup, oral liquids and other pharmaceutically acceptable dose forms.

The present invention provides a compound emodin baicalein injection for curing acute pancreatitis and its preparation method. Said invention adopts the combination of ultrasonic wave method and conventional method to respectively extract effective component emodin and baicalein pure products from rhubarb and scutellaria root, then adopts the following steps: adding the emodin and baicalein pure products and required correspondent auxiliary material into hot injection water, using NaOH solution to regulate pH, adding active carbon, heating to foiling, cooling and filtering by using microporous filtration membrane, adding injection water to total quantity, filling and sterilizing for 30 min at 115 deg.C so as to obtain the injection, cold-storing said injection for 1 week, filtering, filling and freeze-drying, sealing so as to obtain the freeze-dried powder injection finished product.

The invention discloses a synthesis technology of 6, 9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5, 10-dione dimaleate and relates to the technical field of antineoplastic drug synthesis. The synthesis technology comprises that 3, 4-pyridinedicarboxylic anhydride and hydroquinone undergo a reaction in the presence of a catalyst to produce a first intermediate, the first intermediate and N-t-butoxycarbonylethylenediamine undergo a reaction to produce a second intermediate, the second intermediate is subjected to deprotection, and the product and maleic acid undergo a salt forming reaction to produce a product. The prepared product has purity greater than 99.5% and known single impurity and unknown single impurity contents less than 0.1%. The important intermediate of the synthesis technology has stable properties and is convenient for storage. The synthesis technology allows mild reaction conditions, has simple processes, realizes a low cost and is suitable for industrial production. The invention also provides pixantrone dimaleate. The pixantrone dimaleate can be processed to form a freeze-dried powder injection for treating human aggressive non-Hodgkin's lymphoma with easy recurrence and high treatment difficulty.

the invention belongs to the drug technical field, disclosing a sulphur butyl ether-beta- cyclodextrin(SBE-beta-CD) clathrate compound of cinnarizine, a preparation thereof and a preparation method thereof. The water soluble beta- cyclodextrin derivative SBE-beta-CD is used as a coating material to prepare the cinnarizine clathrate compound. The process comprises the following steps that: the BE-beta-CD is dissolved in proper amount of water, the pH value is adjusted by hydrochloric acid, the cinnarizine is added in the mixed solution and stirred for ultrasonic dissolution, the mixed solutionobtained is added with sodium hydroxide to adjust the pH value, a clathrate solution is obtained, and the clathrate solution is subject to freeze drying or spray drying to form clathrate compound powder; the clathrate compound solution obtained is subject to degerming, pyrogen removal, sterile filling and freeze drying to obtain freeze-dry powder needles for injection; the clathrate compound solution is subject to spray drying, and the obtained powder is directly subject to sterile subpackaging or mixed with proper amount of auxiliary materials for sterile subpackaging; and the clathrate compound powder can be mixed with other auxiliary materials to prepare tablets, capsules and particles, etc. according to requirements.

The invention belongs to the field of chemical drugs, and specifically relates to a stabilizer of a lyophilized powder injection for azithromycin injection. The stabilizer is characterized in that the stabilizer is prepared by mixing citric acid and sodium hydroxide, and a mass ratio of the main medicine to the stabilizer is 41-73%:26-59%. With the stabilizer of the present invention, the impurity content in the lyophilized powder injection for azithromycin injection can be effectively reduced, the drug stability can be improved, and the drug use safety can be ensured.

A general ixeris flavone containing luteolin-7-0-beta-D-phranoglucuronide (C21H18O12), a freeze-dried powder injection prepared from said general ixeris flavone, mannitol and the water for injection, and the preparing process and quality control method of said freeze-dried powder injection are disclosed.

The present invention discloses an application of paeonol in preparation of medicine for curing carcinoma of esophagus. Said medicine can be made into various dosage forms.

The present invention provides one kind of freeze dried high concentration milrinone powder for injection and its preparation process. The freeze dried milrinone powder for injection contains: milrinone in 2-10 weight portions; pharmaceutically acceptable acid matter, which is L-aspartic acid, tartaric acid, citric acid, glutamic acid or their combination, in the amount of 0.25-4 times weight of milrinone; and pharmaceutically acceptable carrier in 15-100 weight portions. The freeze dried milrinone powder for injection may be dissolved in water to form injection of milrinone in 2-10 mg/ml concentration, and has high stability.

The invention discloses a composition preparation of 24-methylene cycloartenol feruloyl esterase, and a purification process thereof. The purity of 24-methylene cycloartenol feruloyl esterase purified by the purification process can reach more than 80%. The composition disclosed by the invention contains 24-methylene cycloartenol feruloyl esterase and surface active agent, wherein, the surface active agent is selected from Tween 80, polyethylene glycol 400 or mixture thereof. Meanwhile, the invention also discloses an injection of the composition, in particular to freeze-dry powder injection for injection.

The invention discloses a medicinal composition for preventing and treating osteoporosis, relates to a medicinal composition of bishosphonates and the derivatives of vitamin D and the like, wherein the medicinal composition can be produced into oral preparations or injection preparations by virtue of being mixed with pharmaceutically acceptable auxiliary materials; the oral preparations comprise soft capsules, capsules, common tablets, chewable tablets, dispersible tablets, orally disintegrating tablets, effervescent tablets, buccal tablets, sustained release tablets, sustained release capsules, oral solution, syrup, and the like; and the injection preparations comprise small-volume injections, large-volume injections, freeze-dried powder for injection, and the like. The medicinal composition can be used for preventing and treating various primary or secondary types of osteoporosis.

The present invention discloses one kind of freeze dried nimodipine composition and its preparation. The freeze dried nimodipine composition consists of nimodipine, surfactant, polyglycol as solvent, excipient glycerin and mannitol, etc. The freeze dried nimodipine composition has simple preparation process, high bioavailability, excellent dissolubility and stability, and easy preservation.

The invention discloses a phospholipid complex of natural Baikal skullcap root active ingredients and a preparation method thereof. The natural Baikal skullcap root active ingredients mean an active fraction (the baicalein content is more than 50 percent) or an active ingredient (the baicalein content is more than 90 percent) of baicalein extracted and separated from Baikal skullcap roots serving as a Chinese medicament and an active fraction (the wogomin content is more than 50 percent) or an active ingredient (the wogomin content is more than 90 percent) of wogomin. The water solubility and lipid solubility of the natural Baikal skullcap root active ingredients are poor, the dissolubility of the active ingredients is increased along with rise of the pH value of a solution, and the active ingredients are easily chemically degraded under an alkali condition. Due to the insufficiency of the physical and chemical properties of the natural Baikal skullcap root active ingredients, the active ingredients cannot be prepared into injection, and the bioavailability is low after the active ingredients are orally taken. Through a phospholipid complex technology, the water dispersibility and lipophilic property of the Baikal skullcap root active ingredients are obviously improved, and then the Baikal skullcap root active ingredients can be prepared into high-bioavailability oral preparation, freeze-dried injection or lipid emulsion to meet the requirement for injection or mucosa administration.

The present invention relates to a kind of freeze dried powder for intravenous injection with pyritinol hydrochloride as main component and its preparation process. The freeze dried powder for intravenous injection with pyritinol hydrochloride as main component is prepared by using water for injection or bacteria-free water as solvent, and mannitol and sodium chloride as supplementary material, and through freeze drying process. The present invention has no limitation of requiring bacteria-free material.

The invention relates to a vinpocetine medicament composition which is prepared from the following raw materials: 10-20g of vinpocetine, 20-40g of L-malic acid, 40-80g of polyethylene glycol400 and 2000ml of WFI (water for injection); and the pH is adjusted to 3.3-3.7. The vinpocetine medicament composition is in the form of injection lyophilized powder or injection. The vinpocetine medicament composition contains less auxiliary materials, is good in stability, and has high safety in clinical use.

The invention relates to the technical field of medicament and discloses an etoposide freeze-dried powder preparation used for injection, which is convenient to be used in clinic, is high in bioavailability, is low in cost and can cure solid tumors. The medicament can quickly achieve effective curing concentration in a body when being directly injected through vein or muscle; moreover, the first-pass effect of the medicament to a liver is reduced, the bioavailability of the medicament in the body is improved, and the freeze-dried powder preparation used for injection is more convenient to be transported and can be stored for a longer time. The etoposide freeze-dried powder preparation used for injection contains the etoposide or the pharmaceutically acceptable salt thereof and pharmaceutically acceptable accessories used as active components; wherein, the weight percentage of the etoposide or the pharmaceutically acceptable salt thereof can be 1 to 80 percent, preferably be 30 to 70 percent and more preferably be 40 to 60 percent; the content range thereof in the preparation is generally 1 to 1000mg and preferably be 10 to 500mg.

Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically acceptable carrier and/or adjuvant, wherein the purity of levoisovalerylspiramycin I, II or III is above 90 wt %. The levoisovalerylspiramycin I, II or III has a good antibacterial activity, and the preparations include solution for injection, powder for injection or lyophilized powder for injection.

The invention provides a freeze-dried sterile injection powder containing an active component named levorotation folinic acid; the invention contains 9-100% levorotation folinic acid, 0-91% excipients acceptable in pharmacy or/and appropriate pH moderator. The pharmaceutical excipients refer to one or a plurality of mannitol, dextran, cane sugar, lactose, gelatin and phosphate. The pH moderator refers to one or a plurality of NaOH, natronite, kalium bicarbonicum, sodium phosphate, etc. The invention also relates to the preparation of the freeze-dried sterile injection powder. The invention avoids decomposition caused by high temperature sterilization in the process of levorotation folinic acid preparation, and is suitable for mass production; the invention is low in water content and stable when placed at room temperature, so the invention is suitable for long-term storage. The sterile injection powder of the invention can be taken as a synergist or attenuation agent in tumor chemotherapy.

The invention relates to a hydroxypropyl-Beta-cyclodextrin inclusion compound of bupleurum volatile oil, the preparation method and the application. The bupleurum volatile oil is a fat-soluble component, is hard to dissolve in water, and generally is made into tablet for application, which has low biological utilization degree and influences the curative efficacy. The invention comprises the materials in weight ratio as follows: bupleurum volatile oil: hydroxypropyl-Beta-cyclodextrin = 1:1 to 100; the preparation method is as follow: the bupleurum volatile oil is added into the solution of hydroxypropyl-Beta-cyclodextrin, and then is processed with ultrasonic under the condition of 30 DEG C and 40 KHz, and after cooling and drying, the easily soluble inclusion compound is formed; after inclusion, the solution is remove from the heat source, and filtered with a filtration membrane with 0.22pm micropore, and then is freezed, dried, and made into freeze-dried power injection for injection; excipients are added into the inclusion compound to be made into sublingual tablets.