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Complex rheum officinale-radix scutellariae extract injecta for treating acute pancreatitis and preparing method thereof

A technology for acute pancreatitis and emodin, applied in the field of traditional Chinese medicine injection and its preparation, can solve the problems of inconvenience to patients, affecting curative effect, limiting clinical application and the like

Inactive Publication Date: 2004-09-15
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because "Qingyi Decoction" needs to be administered orally, it brings inconvenience to patients, and also affects the curative effect, which limits clinical application

Method used

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  • Complex rheum officinale-radix scutellariae extract injecta for treating acute pancreatitis and preparing method thereof
  • Complex rheum officinale-radix scutellariae extract injecta for treating acute pancreatitis and preparing method thereof
  • Complex rheum officinale-radix scutellariae extract injecta for treating acute pancreatitis and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] Further detailed description will be given below in conjunction with the production flow chart of the preparation method of compound emodin baicalein injection.

[0061] The first step: extract pure emodin and baicalein. Firstly, the rhubarb and scutellaria baicalensis are subjected to ultrasonic treatment respectively, so that the yield of emodin and baicalein can be increased by more than 8%-10%.

[0062](1), get the rhubarb medicinal material, add 5 to 8 times the amount of ethanol with a concentration of 60%, soak for 24 to 48 hours, put it in an ultrasonic processor and process it for 20 to 30 minutes, and filter the rhubarb medicinal material after ultrasonic treatment to obtain the filtrate Add 3 to 5 times the ethanol of 60% concentration to the residue, put it in an ultrasonic processor and process it for 20 to 30 minutes, then filter to obtain the filtrate, and then combine the two filtrates; HCl and pH9.9 buffer solution were treated sequentially to obtain c...

Embodiment 1

[0074] Example 1: Weigh 125 mg of emodin and 1000 mg of baicalein respectively, add them to hot water for injection, adjust the pH to 6-7 with 10% NaOH solution, add 0.5% activated carbon, heat to a slight boil for 30 minutes, filter, add water for injection to 50ml, filtered through a microporous membrane, filled into 10 5ml injections, and sterilized at 115°C for 30 minutes.

Embodiment 2

[0075] Embodiment 2: Weigh 250 mg of emodin and 1000 mg of baicalein respectively, add them to hot water for injection, adjust the pH to 6-7 with 10% NaOH solution, add 0.5% activated carbon, heat and boil slightly for 30 minutes, filter, add water for injection to 50ml, filtered through a microporous membrane, filled into 10 5ml injections, and sterilized at 115°C for 30 minutes.

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Abstract

The present invention provides a compound emodin baicalein injection for curing acute pancreatitis and its preparation method. Said invention adopts the combination of ultrasonic wave method and conventional method to respectively extract effective component emodin and baicalein pure products from rhubarb and scutellaria root, then adopts the following steps: adding the emodin and baicalein pure products and required correspondent auxiliary material into hot injection water, using NaOH solution to regulate pH, adding active carbon, heating to foiling, cooling and filtering by using microporous filtration membrane, adding injection water to total quantity, filling and sterilizing for 30 min at 115 deg.C so as to obtain the injection, cold-storing said injection for 1 week, filtering, filling and freeze-drying, sealing so as to obtain the freeze-dried powder injection finished product.

Description

technical field [0001] The invention relates to a traditional Chinese medicine injection and a preparation method thereof, in particular to a compound emodin baicalein injection for treating acute pancreatitis and a preparation method thereof. Background technique [0002] Acute pancreatitis is a common clinical emergency with many complications, high mortality, and difficult treatment. The treatment options are divided into two categories: surgery and non-surgical treatment. Drug treatment is the main treatment for non-surgical treatment. "Sandudin" is a western medicine that is widely used in clinical practice, and "Qingyi Decoction" is a representative prescription of traditional Chinese medicine for treating acute pancreatitis, among which rhubarb and scutellaria baicalensis are the two main ingredients in "Qingyi Decoction" . Because "Qingyi Decoction" needs to be administered orally, it brings inconvenience to the patients, and also affects the curative effect, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/352A61P1/18
Inventor 李宗芳张喜平张爱军吴永涛刘效恭
Owner XI AN JIAOTONG UNIV
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