Easily-dismountable multichannel device for cholera diagnosis

A multi-channel, cholera technology, applied in the field of analysis and testing, can solve the problems of troublesome operation of the inner surface modification of PDMS microchannels, large flow resistance, and problems that have not been properly solved.

Inactive Publication Date: 2018-02-02
宋岳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] But it's not that simple
[0008] First, this polydimethylsiloxane material, the material referred to by the acronym PDMS, is itself a strongly hydrophobic material. Microchannels are built on this material. If the microchannels are not targeted The modification operation of the surface of the channel, then, after the overall assembly is completed, that is, after the cover is covered, because the inner surface of the micro channel in the structure occupies most of the inner surface of the liquid flow channel, then the PDMS micro channel The strong hydrophobic characteristic of the inner surface of the channel is the decisive factor, which will make it very difficult for the polar liquid flow similar to the aqueous solution to pass through, and its flow resistance is so large that even ordinary micropumps are difficult to push. Of course, If the cover sheet also chooses to use the PDMS material, then the problem is basically the same, with little difference; therefore, in the prior art, it is necessary to modify and modify the inner surface of the microchannel on the PDMS material; then , is this modification operation for the inner surface of the PDMS microchannel very troublesome? That's not the problem. What constitutes a serious technical proble...

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  • Easily-dismountable multichannel device for cholera diagnosis
  • Easily-dismountable multichannel device for cholera diagnosis
  • Easily-dismountable multichannel device for cholera diagnosis

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Embodiment Construction

[0060] exist figure 1 , figure 2 and image 3In the shown embodiment of the present case, the structure of the device includes a multi-channel microfluidic chip, and the structure of the microfluidic chip includes a substrate 18 and a cover sheet 19 that are attached to each other and installed together. The substrate 18 and the cover sheet 19 are plates or sheets, the surface of the substrate 18 facing the cover sheet 19 contains a groove structure formed by a molding process or an etching process, and the substrate 18 also contains a channel structure that is connected to the groove. The window structure is connected to the channel structure and penetrates the substrate through a molding process, an etching process or a simple punching process. The substrate 18 and the cover sheet 19 are installed together to form a structure containing a channel and a window structure. A microfluidic chip with a liquid pool structure connected to it, the liquid pools are liquid pool 1, l...

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Abstract

The invention relates to an easily-dismountable multichannel device for cholera diagnosis and belongs to the field of analysis and testing. By using cheap and easily-processable polydimethylsiloxane,namely PDMS for manufacturing a substrate of a microfluidic chip for cholera diagnosis, a series of problems exist. The surface of the PDMS material is strongly hydrophobic. Through targeted surface modification, the effect is hard to last. The scheme aims to solve the series of related problems. According to main points of the scheme, PDMS with primitive surface is selected as the substrate, a chain-ring electromagnetic fixture attached with a miniature ultrasonic transducer is in cup joint to be positioned near the terminal of a sample liquid fluid of the microfluidic chip, interfacial tension is reduced by ultrasonic wave, and by PDMS's strong absorption of ultrasonic wave, ultrasonic intensity is rapidly decreased progressively in a short distance to form interfacial tension differencebetween two ends of the chip. Thereby, the sample liquid fluid is driven to flow along an originally hydrophobic capillary channel towards the terminal.

Description

technical field [0001] The invention relates to a multi-channel device for cholera diagnosis which is easy to install and disassemble. The device is a special device for diagnosing cholera antigen based on antigen / antibody specific reaction and belongs to the field of analysis and testing. Background technique [0002] For the technical background of multi-channel microfluidic cholera diagnosis, please refer to CN 200910150930.4 and other invention patent applications. [0003] As far as the overall overview of microfluidic technology itself is concerned, you can refer to the monograph "Illustrated Microfluidic Chip Laboratory" published by the famous microfluidic expert Mr. Lin Bingcheng not long ago, which has been published by Science Press. The past, present, and future prospects of microfluidic technology, etc., have detailed and long-form discussions that go deep into specific details. [0004] So, let's talk about the key issues of this case. [0005] The basic stru...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N27/26G01N33/569
CPCB01L3/5027B01L3/50273B01L2200/10B01L2300/0609B01L2300/0861B01L2300/0887B01L2300/161B01L2400/0439B01L2400/0475G01N27/26G01N33/56911G01N2333/28G01N2800/26Y02A50/30
Inventor 宋岳
Owner 宋岳
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