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Application of butyrate compound in preparation of medicines for preventing and curing NEC

A compound, the technology of butyric acid, applied in the field of medicine, can solve problems such as difficulty in obtaining approval from parents or medical staff, side effects, etc., and achieve the effects of shortening duration, promoting growth and development, and reducing severity

Inactive Publication Date: 2018-02-13
SHANGHAI INST OF PEDIATRIC RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Since necrotizing enterocolitis mainly occurs in infants and young children, the safety of the prevention and treatment method is the first and most important consideration, and if the traditional medicine is used for intervention, it may cause certain side effects, especially for preventive purposes, it is difficult to obtain these years Approval by parents or medical personnel of infants

Method used

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  • Application of butyrate compound in preparation of medicines for preventing and curing NEC
  • Application of butyrate compound in preparation of medicines for preventing and curing NEC
  • Application of butyrate compound in preparation of medicines for preventing and curing NEC

Examples

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Embodiment 1

[0054] This example provides the application of a butyric acid compound in the preparation of a drug for preventing and treating necrotizing enterocolitis.

[0055] The butyric acid compound is at least one selected from butyric acid or pharmaceutically acceptable salts or derivatives thereof.

[0056] The pharmaceutically acceptable salt of butyric acid is at least one selected from sodium butyrate, potassium butyrate, calcium butyrate and magnesium butyrate.

[0057] The pharmaceutically acceptable derivative of butyric acid is selected from butyric acid glyceride, butyric acid mono-diglyceride, ethyl butyrate, methyl butyric acid, isoamyl butyrate, butyric acid cyclodextrin complex at least one.

[0058] The medicine includes a therapeutically effective dose of butyric acid compound.

[0059] The effective dose of the butyric acid compound is 0.05-20 mmol / kg / d.

[0060] The medicine also includes other medicines compatible with the butyric acid compound and pharmaceutica...

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PUM

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Abstract

The invention provides application of a butyrate compound in the preparation of medicines for preventing and curing NEC. The butyrate compound is selected from at least one of butyrate and pharmaceutically acceptable salt or a derivative thereof. The effective constituent such as the butyrate compound is added into the medicines, the condition that the butyrate compound can extremely effectively prevent and cure necrotizing enterocolitis is first discovered, including that the morbidity and mortality of necrotizing enterocolitis are obviously reduced, the time of duration of necrotizing enterocolitis is shortened, the complications of necrotizing enterocolitis are reduced, and / or the order of severity of the complications is alleviated. Moreover, the butyrate compound has the effects of promoting growth and development, maturity of immune system and development of intestinal tracts.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a butyric acid compound in the preparation of medicines for preventing and treating necrotizing enterocolitis. Background technique [0002] Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease in children and one of the important causes of neonatal death. Currently, there is no effective prevention and treatment method in clinical practice. With the advancement of perinatal medicine technology, the birth rate and survival rate of premature infants continue to increase, especially with the application of in vitro fertilization combined with embryo transfer technology, the incidence of NEC has shown an increasing trend in recent years. The long-term outcome of children with NEC is unsatisfactory, and the mortality rate is as high as 15%-50%. Even after successful surgical treatment, complications such as intestinal stenosis and short bowel s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/22A61P1/00A61P29/00
CPCA61K31/19A61K31/22
Inventor 文洁蔡威
Owner SHANGHAI INST OF PEDIATRIC RES
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