Preparation method of disinfectant containing fibroin

A technology of silk protein and disinfectant, applied in the field of medical care products, can solve the problem of skin irritation of the disinfectant, and achieve the effects of good disinfection and antibacterial effect, good moisturizing performance and strong mechanical performance.

Inactive Publication Date: 2018-02-23
关亚玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem to be solved: the purpose of this invention is to solve the technical problem that the existing disinfectant has certain irritation to the skin, and to provide a preparation method of a disinfectant containing silk protein

Method used

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  • Preparation method of disinfectant containing fibroin
  • Preparation method of disinfectant containing fibroin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A method for preparing a disinfectant containing silk protein, comprising the following steps:

[0019] Step 1: Add degummed silk to calcium chloride solution, heat to 60°C and soak for 1.5 hours to obtain silk fibroin solution;

[0020] Step 2, filtering the silk fibroin solution through a coarse filter and then desalting it through a ceramic ultrafiltration membrane to obtain a silk fibroin solution;

[0021] Step 3, in parts by weight, mix 10 parts of silk fibroin solution with 4 parts of oil phase and 0.5 part of emulsifier, and add 0.3 part of chitosan, 0.1 part of stearic acid, 0.5 part of polyacrylamide, Disperse 3 parts of sodium carboxymethyl cellulose, 1 part of sodium alginate, and 2 parts of 85% ethanol.

[0022] Wherein, the concentration of calcium chloride solution in step 1 is 30wt.%, and the dosage ratio of degummed silk and calcium chloride solution is 1g:7mL.

[0023] In step 2, the silk fibroin solution is firstly hydrolyzed and then filtered throu...

Embodiment 2

[0029] A method for preparing a disinfectant containing silk protein, comprising the following steps:

[0030] Step 1, add degummed silk to calcium chloride solution, heat to 70°C and soak for 1 hour to obtain silk fibroin solution;

[0031] Step 2, filtering the silk fibroin solution through a coarse filter and then desalting it through a ceramic ultrafiltration membrane to obtain a silk fibroin solution;

[0032] Step 3, in parts by weight, mix 10 parts of silk fibroin solution with 5 parts of oil phase and 0.7 parts of emulsifier, and add 0.4 parts of chitosan, 0.2 parts of stearic acid, 0.9 parts of polyacrylamide, Disperse 5 parts of sodium carboxymethyl cellulose, 2 parts of sodium alginate, and 3 parts of 85% ethanol.

[0033] Wherein, the concentration of calcium chloride solution in step 1 is 40wt.%, and the dosage ratio of degummed silk and calcium chloride solution is 1g:5mL.

[0034] In step 2, the silk fibroin solution is firstly hydrolyzed and then filtered thr...

Embodiment 3

[0040] A method for preparing a disinfectant containing silk protein, comprising the following steps:

[0041] Step 1, adding degummed silk to calcium chloride solution, heating to 80°C and soaking for 0.5h to obtain silk fibroin solution;

[0042] Step 2, filtering the silk fibroin solution through a coarse filter and then desalting it through a ceramic ultrafiltration membrane to obtain a silk fibroin solution;

[0043] Step 3, in parts by weight, mix 10 parts of silk fibroin solution with 7 parts of oil phase and 0.8 parts of emulsifier, add 0.7 parts of chitosan, 0.3 parts of stearic acid, 1.2 parts of polyacrylamide, Disperse 7 parts of sodium carboxymethyl cellulose, 3 parts of sodium alginate, and 5 parts of 85% ethanol to obtain it.

[0044] Wherein, the concentration of calcium chloride solution in step 1 is 50wt.%, and the dosage ratio of degummed silk and calcium chloride solution is 1g:5mL.

[0045] In step 2, the silk fibroin solution is firstly hydrolyzed and t...

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Abstract

The invention provides a preparation method of a disinfectant containing fibroin. According to the preparation method, degummed silk is added into a calcium chloride solution to be heated and soaked,a silk fibroin solution is filtered by a coarse filter, desalinated through a ceramic ultrafiltration membrane and mixed with an oil phase and an emulsifier, after high-pressure homogenization, chitosan, stearic acid, polyacrylamide, carboxylmethylcellulose sodium, sodium alginate and 85% ethanol are added for dispersion, and the disinfectant containing fibroin is obtained. The obtained disinfectant not only has good effects of disinfection and bacteria resistance, but also has a remarkable effect of skin moisturizing.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to a preparation method of a disinfectant containing silk protein. Background technique [0002] Disinfectant can greatly reduce the chance and quantity of germs entering the human body, and is an indispensable product in the field of medical supplies. An ideal skin disinfectant should be non-toxic, non-residual, non-corrosive, non-irritating, safe for humans and animals, cheap and easy to obtain, and low in environmental pollution. Common skin disinfectants on the market include ethanol preparations, iodine-containing preparations, chlorhexidine, triclosan, quaternary ammonium salts, etc. These disinfectant ingredients are chemical products, which have certain effects on the skin while disinfecting and sterilizing. Stimulation, common skin dryness, cracking, decreased skin resistance, epidermal keratinization, etc. Therefore, the disinfectant that has antib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K9/08A61K47/44A61K47/06A61K47/24A61K47/38A61K47/36A61P31/02A61P31/04A61P31/10A61P17/00A61K31/722A61K31/702
CPCA61K9/0014A61K9/08A61K31/702A61K31/722A61K38/012A61K47/06A61K47/24A61K47/36A61K47/38A61K47/44A61K2300/00
Inventor 关亚玲
Owner 关亚玲
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