Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Purification method of Picoplatin

A purification method and mediplatin technology, applied in the field of platinum antitumor drugs, can solve the problems of low recrystallization yield and low solubility, and achieve the effects of high purity, mild reaction conditions and high yield

Active Publication Date: 2018-03-09
LUNAN BETTER PHARMA
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent uses a mixed solution of N,N-dimethylformamide and hydrochloric acid to dissolve the crude carboplatinum, which has low solubility and low recrystallization yield, and the purity of the obtained products is all below 99%.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dissolve 5.0 g of crude trimethoprim in 55 ml of ether at 50°C, stir for 0.5h, then add 300ml purified water, cool to about 5°C, continue stirring for 1h, filter with suction, and dry for 14h at 100°C to obtain Solid 4.1g, yield 82%, purity 99.96% (HPLC detection), single impurity is less than 0.1%.

Embodiment 2

[0023] Dissolve 5.0g of crude trimethoprim in 25ml dimethyl sulfoxide at 40℃, stir for 0.5h, then add 550ml purified water, cool to about 5℃, continue stirring for 1h, filter with suction, and dry at 100℃ After 14 hours, 4.2 g of solid was obtained, the yield was 84%, the purity was 99.97% (HPLC detection), and the single impurity was less than 0.1%.

Embodiment 3

[0025] Dissolve 5.0g of crude trimethoprim in 30ml ethyl acetate at 20℃, stir for 0.5h, then add 450ml ethanol, cool to about 5℃, continue stirring for 1h, filter with suction, and dry for 14h at 100℃. The obtained solid is 4.2 g, the yield is 84%, the purity is 99.97% (HPLC detection), and the single impurity is less than 0.1%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a purification method of an anti-tumor drug Picoplatin. The technological process comprises the following steps: dissolving a Picoplatin crude product with an organic solvent at a certain temperature; adding a crystallization solvent into the solution for crystallization at a certain temperature; filtering and drying, so as to obtain a Picoplatin highly-finished product. The purification method of the Picoplatin is simple in operation and comparatively high in yield, the purity of the highly-finished product can reach 99.9% or above, a single impurity can be controlledunder 0.1%, and total impurities can be controlled within 0.2%.

Description

Technical field [0001] The invention relates to platinum anti-tumor drugs, in particular to a purification method of trimethoprim. Background technique [0002] Mepyridine platinum, also known as picoplatin and picoplatin, is chemically named cis-dichloro-ammonia, (2-methylpyridine) platinum (Ⅱ) [cis-amminedichloro(2-methylpyridine)–platinate(Ⅱ)] , Is a new generation of anti-tumor drugs. It was first jointly developed by JohnsonMatthey in the United Kingdom, Anormed in Canada and the Cancer Institute in the United Kingdom. It is a new type of platinum complex with steric hindrance, and it has shown good anti-tumor activity both in vivo and in vitro. [0003] The anti-tumor effect of trimethoprim is similar to that of cisplatin, but it is less toxic; it has no cross-resistance to cisplatin and is effective against multiple cisplatin-resistant cells, which can partially overcome the drug resistance caused by cisplatin; it can be administered intravenously or orally medicine. [000...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00
CPCC07F15/0093
Inventor 张贵民王洪刚王亚辉刘统郭小为
Owner LUNAN BETTER PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com