Composite aminophylline nano dispersant and preparation method thereof

Abstract

The invention discloses a compound aminophylline nano-dispersant and a preparation method thereof. Each 1000 milliliter aminophylline dispersant contains: 10-20 grams of aminophylline, 5-10 grams of cholophylline, 1-2 grams of astragalus, Chuan Fritillaria 2-2 grams, essence 0.1-2.0 grams, sweetener 1-10 grams, and the rest is water. The preparation method comprises the following steps: 1) weighing the aminophylline and the sweetener in the prescribed amount, adding 800 milliliters of purified water, stirring and completely dissolving them; 2) adding the essence in the prescribed amount, stirring fully to dissolve them completely; 3) The dispersant is prepared into a solution of 1.0-10.0g / 100ml, and the pH of the solution is adjusted to 8.0-10.0; 4) Add purified water to make it 1000ml. 5) After filtering with a 0.22 μm filter membrane, stir and disperse using a nano-disperser. The dispersant of the invention has good taste, stable quality, can accurately calculate dosage, and reduces the occurrence of adverse reactions that may be caused by inaccurate dosage. Moreover, the preparation method is simple to operate, does not require a sterilization step, does not require special equipment, has a short preparation cycle, and is low in cost.

Description

technical field

[0001] The invention belongs to the field of drug synthesis, and in particular relates to a compound aminophylline nano-dispersant and a preparation method thereof. Background technique

[0002] Due to the deteriorating environmental quality, air pollution has become a major public hazard that endangers human life. Smoking and drug abuse are becoming more and more common. At the same time, various new viruses, bacteria, chlamydia and other pathogenic microorganisms are complicated. The incidence of respiratory diseases has greatly increased, seriously affecting the quality of life of the public. Aminophylline, as a commonly used drug for respiratory diseases, not only requires the standardization and standardization of clinical use, but also needs to be further developed and researched to improve its safety and curative effect, thereby contributing to the treatment of diseases.

[0003] Theophylline has been used to treat bronchial asthma for decades. Becaus...

Examples

Embodiment 1

[0017] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:

[0018] (1) Weigh 10g of aminophylline, 5g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;

[0019] (2) Add 0.1g essence, stir well to make it dissolve completely;

[0020] (3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0021] (4) Add purified water to make up to 1000ml.

[0022] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.

Embodiment 2

[0024] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:

[0025] (1) Weigh 10g of aminophylline, 10g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;

[0026] (2) Add 0.1g essence, stir well to make it dissolve completely;

[0027] (3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0028] (4) Add purified water to make up to 1000ml.

[0029] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.

Embodiment 3

[0031] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:

[0032] (1) Weigh 10g of aminophylline, 10g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;

[0033] (2) Add 0.1g essence, stir well to make it dissolve completely;

[0034] (3) The dispersant PEG-4000 is prepared into a 10.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0035] (4) Add purified water to make up to 1000ml.

[0036] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.

technical field

[0001] The invention belongs to the field of drug synthesis, and in particular relates to a compound aminophylline nano-dispersant and a preparation method thereof. Background technique

[0002] Due to the deteriorating environmental quality, air pollution has become a major public hazard that endangers human life. Smoking and drug abuse are becoming more and more common. At the same time, various new viruses, bacteria, chlamydia and other pathogenic microorganisms are complicated. The incidence of respiratory diseases has greatly increased, seriously affecting the quality of life of the public. Aminophylline, as a commonly used drug for respiratory diseases, not only requires the standardization and standardization of clinical use, but also needs to be further developed and researched to improve its safety and curative effect, thereby contributing to the treatment of diseases.

[0003] Theophylline has been used to treat bronchial asthma for decades. Becaus...

Examples

Embodiment 1

[0017] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:

[0018] (1) Weigh 10g of aminophylline, 5g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;

[0019] (2) Add 0.1g essence, stir well to make it dissolve completely;

[0020] (3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0021] (4) Add purified water to make up to 1000ml.

[0022] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.

Embodiment 2

[0024] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:

[0025] (1) Weigh 10g of aminophylline, 10g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;

[0026] (2) Add 0.1g essence, stir well to make it dissolve completely;

[0027] (3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0028] (4) Add purified water to make up to 1000ml.

[0029] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.

Embodiment 3

[0031] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:

[0032] (1) Weigh 10g of aminophylline, 10g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;

[0033] (2) Add 0.1g essence, stir well to make it dissolve completely;

[0034] (3) The dispersant PEG-4000 is prepared into a 10.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0035] (4) Add purified water to make up to 1000ml.

[0036] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.

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