Composite aminophylline nano dispersant and preparation method thereof
A compound aminophylline and dispersant technology, which is applied to non-active ingredient medical preparations, active ingredient-containing medical preparations, and pharmaceutical formulas, can solve the problems of excitement, abdominal discomfort, central nervous system, and high bioavailability. To achieve the effect of narrow particle distribution
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Embodiment 1
[0017] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:
[0018] (1) Weigh 10g of aminophylline, 5g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;
[0019] (2) Add 0.1g essence, stir well to make it dissolve completely;
[0020] (3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;
[0021] (4) Add purified water to make up to 1000ml.
[0022] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.
Embodiment 2
[0024] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:
[0025] (1) Weigh 10g of aminophylline, 10g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;
[0026] (2) Add 0.1g essence, stir well to make it dissolve completely;
[0027] (3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;
[0028] (4) Add purified water to make up to 1000ml.
[0029] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.
Embodiment 3
[0031] A compound aminophylline nano-dispersant, the preparation method comprising the following steps:
[0032] (1) Weigh 10g of aminophylline, 10g of cholophylline, 1g of astragalus, 2g of Fritillaria chinensis, 0.1g of essence, 5g of sweetener, add 800ml of purified water, stir and make it dissolve completely;
[0033] (2) Add 0.1g essence, stir well to make it dissolve completely;
[0034] (3) The dispersant PEG-4000 is prepared into a 10.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;
[0035] (4) Add purified water to make up to 1000ml.
[0036] (5) After filtering with a 0.22 μm filter membrane, stir and disperse using a CIK2000 nano-disperser to obtain a compound aminophylline nano-dispersant.
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