Bromhexine hydrochloride nano cough syrup and preparation method thereof

A technology of bromhexine hydrochloride and cough syrup, which is applied in the fields of pharmaceutical formulations, drug delivery, respiratory diseases, etc., can solve the problems of difficult tablet integrity, complicated production process, high production cost, etc., and achieve narrow particle size distribution Effect

Inactive Publication Date: 2018-04-13
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the traditional cough medicine tablets are too large, the production process is complicated, the prepared tablets are low in hardness and fragile, it is difficult to maintain the integrity of the tablets, and special packaging is required to prevent the tablets from breaking. High production cost and other disadvantages, the bromhexine hydrochloride nano-cough syrup can determine the dosage of tablets according to one's own body weight, realizing personalized drug administration, making the intake of drugs more accurate and safer; at the same time, the active ingredients of the drug are in the form of nano Grade form is highly soluble in cough syrup, which is conducive to full absorption and high bioavailability

Method used

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  • Bromhexine hydrochloride nano cough syrup and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0021] A kind of bromhexine hydrochloride nano cough syrup, the preparation method comprises the following steps:

[0022] The preparation method comprises the following steps:

[0023] 1) Weigh 10 g of bromhexine hydrochloride and 1 g of sweetener, add 800 ml of purified water, stir and make it dissolve completely;

[0024] 2) Add 0.1 of adhesive and lubricant, stir well to dissolve completely;

[0025] 3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0026] 4) Add purified water to make the volume to 1000ml;

[0027] 5) After filtering with a 0.22 μm filter membrane, use a CIK2000 nano-disperser to stir and disperse to obtain bromhexine hydrochloride nano-dispersant;

[0028] 6) Distill the bromhexine hydrochloride nano-dispersant under reduced pressure, disperse it into a gel with a nano-disperser, and prepare the bromhexine hydrochloride nano-cough syrup.

Embodiment 2

[0030] 1) Weigh 5 g of bromhexine hydrochloride and 1 g of sweetener, add 800 ml of purified water, stir and make it dissolve completely;

[0031] 2) Add 0.1 of adhesive and lubricant, stir well to dissolve completely;

[0032] 3) The dispersant PEG-4000 is prepared into a 1.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0033] 4) Add purified water to make the volume to 1000ml;

[0034] 5) After filtering with a 0.22 μm filter membrane, use a CIK2000 nano-disperser to stir and disperse to obtain bromhexine hydrochloride nano-dispersant;

[0035] 6) Distill the bromhexine hydrochloride nano-dispersant under reduced pressure, disperse it into a gel with a nano-disperser, and prepare the bromhexine hydrochloride nano-cough syrup.

Embodiment 3

[0037] 1) Weigh 10 g of bromhexine hydrochloride and 1 g of sweetener, add 800 ml of purified water, stir and make it dissolve completely;

[0038] 2) Add 0.1 of adhesive and lubricant, stir well to dissolve completely;

[0039] 3) The dispersant PEG-4000 is prepared into a 10.0g / 100ml solution, and ethylenediamine is added to adjust the pH to 8.2;

[0040] 4) Add purified water to make the volume to 1000ml;

[0041] 5) After filtering with a 0.22 μm filter membrane, use a CIK2000 nano-disperser to stir and disperse to obtain bromhexine hydrochloride nano-dispersant;

[0042] 6) Distill the bromhexine hydrochloride nano-dispersant under reduced pressure, disperse it into a gel with a nano-disperser, and prepare the bromhexine hydrochloride nano-cough syrup.

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Abstract

The invention discloses a bromhexine hydrochloride nano-cough syrup and a preparation method thereof, comprising 40-60 parts of bromhexine hydrochloride, 30-60 parts of a filler, 2-8 parts of swelling auxiliary materials, 1-5 parts of an adhesive, 0.5-1 part of lubricant and 1-3 parts of sweetener are prepared by dissolving, mixing, vacuum distillation, and dispersing into a gel by a nanometer disperser. The comparison test results of the prepared bromhexine hydrochloride cough syrup and the commercially available cough syrup show that the present invention disintegrates quickly, has high dissolution rate and dissolution rate, short time to peak blood drug concentration, rapid release-absorption, complete tablet appearance, and Stronger hardness, delicate and refreshing taste, no gritty feeling; compared with the existing technology of preparing orally disintegrating tablets by freeze-drying, vacuum drying, and spray-drying methods, the present invention does not require special production equipment and conditions, nor does it require special packaging. The preparation process is simple, the cost is low and the benefit is high.

Description

technical field [0001] The invention belongs to the field of drug synthesis, and in particular relates to a bromhexine hydrochloride nano cough syrup and a preparation method thereof. Background technique [0002] Due to the deteriorating environmental quality, air pollution has become a major public hazard that endangers human life. Smoking and drug abuse are becoming more and more common. At the same time, various new viruses, bacteria, chlamydia and other pathogenic microorganisms are complicated. The incidence of respiratory diseases has greatly increased, seriously affecting the quality of life of the public. As a commonly used drug for respiratory diseases, bromhexine hydrochloride not only requires the standardization and standardization of clinical use, but also needs to be further developed and researched to improve its safety and curative effect, thus contributing to the treatment of diseases . [0003] Bromhexine hydrochloride is an expectorant, which is a semi-...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/137A61K47/10A61P11/14
CPCA61K31/137A61K9/0095A61K47/10
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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