The invention discloses a bromhexine hydrochloride nano-cough syrup and a preparation method thereof, comprising 40-60 parts of bromhexine hydrochloride, 30-60 parts of a filler, 2-8 parts of swelling auxiliary materials, 1-5 parts of an adhesive, 0.5-1 part of lubricant and 1-3 parts of sweetener are prepared by dissolving, mixing, vacuum distillation, and dispersing into a gel by a nanometer disperser. The comparison test results of the prepared bromhexine hydrochloride cough syrup and the commercially available cough syrup show that the present invention disintegrates quickly, has high dissolution rate and dissolution rate, short time to peak blood drug concentration, rapid release-absorption, complete tablet appearance, and Stronger hardness, delicate and refreshing taste, no gritty feeling; compared with the existing technology of preparing orally disintegrating tablets by freeze-drying, vacuum drying, and spray-drying methods, the present invention does not require special production equipment and conditions, nor does it require special packaging. The preparation process is simple, the cost is low and the benefit is high.