Application of NFI transcription factors in esophageal squamous cell carcinoma

A technology of esophageal squamous cell carcinoma and transcription factors, applied in the field of biomedicine

Active Publication Date: 2018-04-13
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the relationship between NFIA in the staging and prognosis of esophageal squamous cell carcinoma.

Method used

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  • Application of NFI transcription factors in esophageal squamous cell carcinoma
  • Application of NFI transcription factors in esophageal squamous cell carcinoma
  • Application of NFI transcription factors in esophageal squamous cell carcinoma

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Embodiment Construction

[0038] specific implementation

[0039] The present invention studies the clinicopathological data of patients with squamous cell carcinoma of the esophagus who have received surgical treatment, and uses immunohistochemistry (IHC) in the immunoassay method to observe the effects of NFIA and NFIB in cancer tissues and paracancerous tissues of patients with squamous cell carcinoma of the esophagus. Combined with the clinicopathological data and follow-up data of these patients, the relationship between the expression of NFIA and NFIB in esophageal squamous cell carcinoma and the clinicopathological characteristics and prognosis of patients was discovered for the first time.

[0040] landmark

[0041] The term "marker", "molecular marker" or "biomarker" refers to a molecule that is a target for analysis of a test sample of an individual. In one embodiment, examples of such molecular targets are proteins or polypeptides. Proteins or polypeptides used as markers in the present in...

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Abstract

The invention discloses the application of NFI transcription factors in esophageal squamous cell carcinoma, and particularly relates to the application of a transcription factor NFIB in the diagnosisof esophageal squamous cell carcinoma and the application of a transcription factor NFIA in evaluating the differentiation degree, TNM staging and prognosis of esophageal squamous cell carcinoma. Thelevel of the NFI transcription factors of esophageal squamous cell carcinoma is detected and analyzed by the immunohistochemical technique, it is found that patients with high expression of NFIA havea low tumor differentiation degree, a high TNM stage and poor prognosis, and high expression of NFIB corresponds to a low esophageal squamous cell carcinoma tissue differentiation degree, in this way,a new way is provided for the diagnosis and prognosis judgment of esophageal squamous cell carcinoma, and a reference is provided for clinicians to analyze the condition of patients with esophageal squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of NFI transcription factor in esophageal squamous cell carcinoma, in particular to the application of transcription factors NFIA and NFIB in esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is a malignant tumor that occurs in the esophagus. According to the pathological type, it is mainly divided into adenocarcinoma and squamous cell carcinoma. my country is an area with a high incidence of esophageal cancer, of which squamous cell carcinoma accounts for about 90%. Due to the limited role of biological therapy in the treatment of esophageal cancer, the current treatment methods for esophageal cancer are mainly surgery, radiotherapy and chemotherapy. Although the current radical resection combined with postoperative radiotherapy and chemotherapy for esophageal squamous cell carcinoma has greatly improved the survival time of patients and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/68G01N33/574
CPCC12Q1/6886C12Q2600/158C12Q2600/178G01N33/57407G01N33/68G01N2333/4703
Inventor 周智航黄伟龚文平李立宋锦文余琦
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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