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A kind of pharmaceutical composition for treating depression

A composition and technology for depression, applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve the problems of difficult to determine active ingredients and mechanism of action, complex natural drug ingredients, narrow antidepressant spectrum, etc., and achieve fast onset of western medicine. , Improve the effect of slow drug effect and significant curative effect

Inactive Publication Date: 2021-01-08
SUZHOU SCI&TECH TOWN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, synthetic drugs have defects such as narrow antidepressant spectrum, large side effects, high drug price, and easy relapse; natural drugs have problems such as complex ingredients, slow efficacy, and difficulty in determining the active ingredients and mechanism of action.

Method used

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  • A kind of pharmaceutical composition for treating depression
  • A kind of pharmaceutical composition for treating depression
  • A kind of pharmaceutical composition for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of traditional Chinese medicine extract: (1) washing and drying 10 parts by weight of Chinese date seed, 5 parts by weight of jasmine, 5 parts by weight of rehmannia glutinosa, and 3 parts by weight of Cyperus cyperi for future use; (2) coarsely crushing the spare Chinese medicine and passing through Sieve, mix evenly in the water extraction tank, add water 8 times the weight of the medicinal materials and decoct for 2 hours, and collect the filtrate; (3) Repeat the decoction 3 times, filter to remove the filter residue, and combine the filtrate after each decoction; (4) ) concentrating the combined filtrate to paste under reduced pressure, and dispersing and drying the paste product through a 100-mesh sieve to obtain paste powder.

[0019] The antidepressant active factor capsaicin esters are prepared by a synthetic method: 0.1 mol of capric acid and 0.1 mol of 4-hydroxy-3-methoxybenzyl alcohol are heated and refluxed in an ethanol solution containing 1 mol / ...

Embodiment 2

[0022] In the preparation process of the Chinese medicine extract of Example 1, the consumption of four kinds of Chinese medicines was adjusted to: 8 parts by weight of Jujube Semen, 4 parts by weight of Jasmine, 4 parts by weight of Rehmannia glutinosa, and 2 parts by weight of Rhizoma Cyperi, and the rest of the preparation process was the same as in Example 1. .

Embodiment 3

[0024] In the preparation process of the antidepressant active factor in Example 1, capric acid was replaced with palmitic acid, and the rest of the preparation process was the same as in Example 1.

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Abstract

The invention relates to a pharmaceutical composition for treating depression. The pharmaceutical composition contains a traditional Chinese medicine extract and anti-depression active factors, wherein the traditional Chinese medicine extract is prepared by proportioning spina date seed, jasmine, rehmannia and cyperus rotundus according to a specific weight ratio, decocting and concentrating, thereby obtaining the product; and the anti-depression active factors are capsaicine substances. The pharmaceutical composition disclosed by the invention has the advantages of mild traditional Chinese medicines, small side effects and low irritation, also has the advantages of being fast in efficacy of Western medicines and capable of realizing specified treatment. Moreover, the raw materials are lowin cost, and the price has competitiveness.

Description

technical field [0001] The invention relates to the field of antidepressants, in particular to a pharmaceutical composition for treating depression. Background technique [0002] Depression is a high-incidence mental illness. Patients are characterized by persistent depression and cognitive impairment, which not only seriously affects the physical and mental health and quality of life of patients, but also brings heavy burdens to families and society. Depression is manifested as a psychological or affective disorder with depression as the main symptom. According to the statistics of WHO and related medical institutions, the incidence of depression is 3-5%. In the general population, about 25% of women and about 10% of men Left and right, have experienced depression in their lifetime. Treatment for depression can be divided into drug therapy, psychotherapy, social therapy and behavioral therapy. Many methods are used clinically comprehensively, among which drug therapy play...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/23A61K36/8905A61P25/24A61P25/22
CPCA61K31/23A61K36/63A61K36/725A61K36/804A61K36/8905A61K2236/331A61K2236/39A61K2300/00
Inventor 张太泉
Owner SUZHOU SCI&TECH TOWN HOSPITAL