A kind of hydrophilic coating on medical metal surface and preparation method thereof

Abstract

The invention provides a medical hydrophilic coating on a metal surface. The medical hydrophilic coating comprises a polymer elastic precoat layer arranged on the metal surface, and a hydrophilic cross-link layer arranged on the surface of the polymer elastic precoat layer, wherein the hydrophilic cross-link layer is formed by a hydrophilic polymer, an adhesive and a crosslinking agent, and the adhesive is a polymer which can react with the hydrophilic polymer and the crosslinking agent. Compared with the prior art, the polymer elastic precoat layer is firstly arranged on the metal surface, has excellent ultra-thin elasticity and bonding performance, and can effectively ensure that the hydrophilic coating does not fall off, tear or influence the original flexibility of a metal when the metal is bent; meanwhile, according to the invention, the lubricity and the bonding force of the hydrophilic cross-link layer can be adjusted by adjusting the proportions of the hydrophilic polymer and the crosslinking agent in the hydrophilic cross-link layer, and the adhesive added in the hydrophilic cross-link layer can form a crosslinking network with the hydrophilic polymer, thereby reducing theamount of the hydrophilic polymer dissolved in water or blood and improving the durability of the hydrophilic coating.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a hydrophilic coating on a medical metal surface and a preparation method thereof. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, it is not only convenient to operate, but also reduces the pain of patients due to the low trauma of interventional treatment , the risk of treatment is small, and the cost of treatment is relatively low, so this technology has been widely promoted and used in the medical field. The current medical devices used in interventional therapy operations are mainly Class III medical devices, which are mainly composed of medical interventional polymer materials, medical interventional wires and medical interventional metal guide wire spring materials. T...

AI Technical Summary

Problems solved by technology

[0005] At present, there are many patents on hydrophilic coatings, but they are mainly applied to the surface of polymer polymers, such as US6042876, US4875287, US5509899, ​​US5331027 and US5620738, which disclose a hydrophilic coating containing polyvinylpyrrolidone (PVP). Water coating, the coating is divided into two layers, but because no cross-linking structure is introduced into the two layers of coating, the hydrophilic coating prepared by this method is easy to fall off after absorbing water and swelling, and the coating has poor firmness

Another example is that the U.S. Patent No. US4666437, US5179174, US8287890B2, US6299980B1 and US5160790 disclose a coating that introduces a crosslinking agent. The crosslinking agent is isocyanate. In addition to hydrophilic polymers such as ethylene (PEO), polyols or polyamines that can react with crosslinking agents are also added. However, since hydrophilic polymers do not participate in the crosslinking reaction in the system, they will undergo friction after absorbing water and swelling. Still peels off the coating substrate easily

Another example is that the U.S. patents whose patent numbers are US8513320B2, US7534495B2, US 8039524B2, US 7696259B2, US8378011B2, and US 8512795B2 all disclose a coating formed by UV curing, including double bond compounds and hydrophilic polymers, in the solvent. Under the action of mixing, it is evenly coated on the surface of the device, and then cured by ultraviolet light to obtain a cross-linked structure, but the coating still has the problem of poor durability after water absorption

[0006] Zhao Lei described the method of preparing a hydrophilic coating on the surface of a metal stent in his doctoral dissertation "Preparation of a New Hydrophilic Coated Coronary Stent and Related Research", using hydroxylation on the surface of stainless steel and then silanization , react with different silane coupling agents to form silane-derived materials combined with different hydrophilic groups on the surface of the coronary stent, but the hydrophilic coating cannot form a complete gel water film when it meets water, which cannot reach to good lubrication

[0007] The Chinese patent with the publication number CN106634389A discloses a method for preparing a hydrophilic coating on the surface of aluminum foil, but this method is used on the surface of aluminum foil for air-conditioning heat exchange fins, which is not of biomedical grade and has limited lubricity in contact with water, which cannot meet the requirements of interventional products. Requirements

The Chinese patents whose publication numbers are CN107213530A and CN107158484A both disclose a method for preparing a hydrophilic antibacterial coating on the surface of a stainless steel medical device, which solves the problem that bacteria are easy to breed on the surface of the current medical device and cause secondary infection at the implantation site, but the No cross-linking agent or sub-cross-linking agent is used in the coating, and the pure hydrophilic polymer has limited binding force with the surface of the device, so it cannot provide good coating durability and smoothness

[0008] To sum up, the current domestic hydrophilic coatings are mainly used on the surface of polymer polymers, which cannot be well applied to the surface of metal materials for medical intervention, especially for the production of hydrophilic coatings on the surface of metal guide wire springs for medical intervention. Its flexibility, durability, smoothness and tear resistance are not ideal

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