Sodium cantharidate and preparation method thereof

Abstract

The invention discloses a sodium cantharidate and a preparation method thereof, which comprises the following components: mylabris, hydrochloric acid, acetone, absolute ethanol, petroleum ether, sodium hydroxide and medicinal charcoal; the sodium cantharidate and the preparation method thereof are weighed The coarse powder of cantharidin is extracted by reflux in an explosion-proof glass dipping tank, the extract is collected and the filtrate is discarded, washed and impurities are removed to obtain the crude cantharidin, which is dissolved in acetone and then recrystallized. The acetone is evaporated until the crystals are separated out, and the obtained product is obtained by suction filtration. Cantharidin high-quality goods, slowly drip into sodium hydroxide solution, after the reaction is complete, add medicinal charcoal aqueous solution, and suction filter while it is hot to obtain sodium cantharidate solution, then dry it, and actually make sodium cantharidate fine powder The purity is high, and the effect of dissolving in water is better, so that the utilization rate of resources in the process of use is higher, and the bioabsorption rate also increases accordingly. The preparation method uses exquisite materials, and the actual production capacity is outstanding. Chemical recovery rate.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to sodium cantharidate and a preparation method thereof. Background technique [0002] Mylabris is also known as spotted oyster, piebald hair, spotted cat, coriander, flower beetle, Zhangwa, soybean worm, etc., commonly known as Spanish fly. Mylabris is oblong, 1.5-2.5cm long, 0.5-1cm wide, with a head and mouthparts Vertically downward, with large compound eyes and 1 pair of antennae, most of which have fallen off, with 1 pair of leathery elytra on the back, black, with 3 yellow or brown horizontal striated wings and brown film-like transparent inner wings below 2 pieces, black chest and abdomen, 3 pairs of legs on the chest, special odor, cantharidin has strong nephrotoxicity, is a highly toxic substance, and can secrete a liquid called cantharidin, which is used to defend against enemies. Since the ancient Greek period, there have been records of using this liquid as an aphrodi...

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem of low utilization rate of existing drugs and certain side effects, the purpose of the present invention is to provide a sodium cantharidate and a preparation method thereof. The sodium cantharidate has the basic characteristics of high solubility and high utilization rate. The most important thing is that it can be stored at normal temperature for two years without deterioration tendency, so as to solve the problems raised in the above-mentioned background technology

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