Use of spiroketal polyacetylene compounds in the preparation of anti-efflux pump drug-resistant Staphylococcus aureus sensitization drugs

A technology of polyacetylenes and spiroketals, applied in the field of pharmacy, can solve the problems of limiting the clinical application of oxacillin, serious bacterial resistance and the like
CN107951878BActive Publication Date: 2021-07-02FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2021-07-02

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Abstract

The invention belongs to the field of pharmacy, and relates to the use of spiroketal polyacetylene compounds in the preparation of sensitization drugs for drug-resistant Staphylococcus aureus. Oxacillin can produce antibacterial and synergistic effects in a synergistic manner, especially through the combination of spiroketal polyacetylenes and oxacillin, it can significantly reduce the minimum inhibitory concentration of oxacillin, and has a negative effect on oxacillin. Synergistic effect against drug-resistant Staphylococcus aureus. The spiroketal polyacetylene compound can be used in the sensitization drug against the multi-drug resistant Staphylococcus aureus strain EMRSA‑16 containing the mecA efflux pump drug resistance gene, and the compound and oxacillin A pharmaceutical composition with anti-drug-resistant Staphylococcus aureus effect.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and relates to the use of spiroketal polyacetylene compounds in the preparation of anti-efflux pump drug-resistant Staphylococcus aureus sensitization drugs, especially the use of spiroketal polyacetylene compounds in anti-mecA efflux pump resistance Use of pharmacogenes in the sensitization of multidrug-resistant Staphylococcus aureus strain EMRSA-16. Background technique

[0002] Methicillin-Resistant Staphylococcus aureus (MRSA) is one of the most common infectious bacteria in hospitals. Studies have shown that MRSA is resistant to all lactam antibiotics such as penicillin and other antibiotics, and also resistant to macrolides, fluoroquinolones, tetracyclines and other antibiotics, which makes its Infections become more difficult to treat. Currently, only vancomycin is the only antibiotic available for the treatment of MRSA. Unfortunately, in 2002, MRSA strains completely resistant to vancomycin app...

Claims

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