A kind of medicinal pellet core and preparation method thereof

A technology for pellet cores and pellets, applied in the field of medicinal pellet cores and their preparation, can solve the problems of particle size uniformity, roundness and surface finish not reaching a satisfactory level, and unstable product quality.

Active Publication Date: 2022-02-25
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of pellet cores in the above two patents requires less equipment and simple process implementation, but the particle size uniformity, roundness and surface finish are not satisfactory, and the quality of the finished product is also unstable.

Method used

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  • A kind of medicinal pellet core and preparation method thereof
  • A kind of medicinal pellet core and preparation method thereof
  • A kind of medicinal pellet core and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0023] Embodiment 2. The anhydrous glucose pellet core, wherein the dosage ratio of the mother core component and the centrifuge encapsulation component is 1:2.

[0024]

[0025]

[0026] The preparation method is:

[0027] a. Crush and sieve each component, weigh each component according to the prescription amount, dissolve PVP K-30 in water to make an aqueous binder solution, and place the anhydrous glucose and MCC101 in the mother core component in a wet granulator After mixing evenly, add the binder aqueous solution to prepare the mother core.

[0028] b. Turn on the centrifugal packaging machine, put the prepared mother core into the centrifugal packaging machine, adjust the rotating speed, and use the anhydrous glucose and starch in the centrifugal packaging composition to supply powder while spraying the binder solution. The mother core is layered and powdered, and finally the prepared pellets are sieved.

Embodiment 3

[0029] Embodiment 3. The anhydrous glucose pellet core, wherein the dosage ratio of the mother core component and the centrifuge encapsulation component is 1:2.5.

[0030]

[0031]

[0032]

[0033] The preparation method is:

[0034] a. Crush and sieve each component, weigh each component according to the prescription amount, dissolve PVP K-30 in water to make an aqueous binder solution, and place the anhydrous glucose and MCC101 in the mother core component in a wet granulator After mixing evenly, add the binder aqueous solution to prepare the mother core.

[0035] b. Turn on the centrifugal packaging machine, put the prepared mother core into the centrifugal packaging machine, adjust the rotating speed, and use the anhydrous glucose and MCC101 in the centrifugal packaging composition to supply powder while spraying the binder solution. The mother core is layered and powdered, and finally the prepared pellets are sieved.

Embodiment 4

[0036] Embodiment 4. Glucose monohydrate pellet core, wherein the dosage ratio of mother core component and centrifuge encapsulation component is 1:2.5.

[0037]

[0038]

[0039] The preparation method is:

[0040] a. Crush and sieve each component, weigh each component according to the prescription amount, dissolve PVP K-30 in water to make an aqueous binder solution, and place glucose monohydrate and MCC101 in the mother core component in a wet granulator After mixing evenly, add the binder aqueous solution to prepare the mother core.

[0041]b. Turn on the centrifugal packaging machine, put the prepared mother core into the centrifugal packaging machine, adjust the rotating speed, and use the glucose monohydrate and MCC101 in the centrifugal packaging composition to supply powder while spraying the binder solution. The mother core is layered and powdered, and finally the prepared pellets are sieved.

[0042] 2. Determination of traits or properties:

[0043] 1) Ph...

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Abstract

The present invention provides a medicinal micropill core with excellent properties and excellent indicators, and a method for preparing a micropill core that is simple in process, does not require high equipment level, and is convenient for industrial production. The micropill core in the present invention, its Contains main ingredients, diluents and binders, and is prepared using glucose as the main ingredient. Therefore, it can be used as a base pill for further drug administration, and can also be provided to patients as a sugar supplement product in clinical treatment.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a medicinal pellet core and a preparation method thereof. Background technique [0002] The core of pharmaceutical pellets is a nearly spherical particle made of inert auxiliary materials or main drug and auxiliary materials. Inert ball cores are usually used as substrates and carriers in production. The drug-containing pellet core has different uses according to the differences between varieties, such as further coating with functional coatings to obtain sustained-release or delayed-release pellets with different drug-release properties. In terms of properties, for pellet cores, it is generally required to have good roundness, low friability, smooth surface, good flatness, and good fluidity, which can meet the requirements of further drug application and coating processes, or filling processes. There are many ways to prepare pellet cores, the main prepara...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/26A61K47/38A61K47/36A61K47/32A61K31/7004A61P3/00
CPCA61K9/1623A61K9/1635A61K9/1652A61K9/167A61K31/7004
Inventor 张长青朱德志咸小燕宁洁张胜海
Owner 北京科信聚润医药科技有限公司
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