Copper oxide nonenzymatic glucose electrochemical sensor

A technology of copper oxide and glucose, which is applied in the detection field, can solve the problems of easy poisoning and high price, and achieve the effect of excellent selectivity and excellent performance of glucose detection

Active Publication Date: 2018-05-04
NORTHEAST DIANLI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among the many materials that can detect glucose concentration, the noble metals Pt, Au and their composite materials have the disadvantages of high price and easy poisoning.

Method used

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  • Copper oxide nonenzymatic glucose electrochemical sensor
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  • Copper oxide nonenzymatic glucose electrochemical sensor

Examples

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Effect test

Embodiment 1

[0040] Preparation of a raspberry-shaped copper oxide material and construction of a non-enzymatic glucose sensor, including the preparation of raspberry-shaped copper oxide, the preparation of the raspberry-shaped copper oxide: Weigh 0.2 g P123 and dissolve it in 3.8 mL ethanol, ultrasonic 15 min to dissolve, add 0.399 g copper nitrate and 0.045 g HMT to sonicate until dissolved, and obtain a stable solution, add 46 mL of ethylene glycol, high-density ultrasonic for 30 min, and react at 200 °C for 24 hours to obtain a precipitate. washed three times with ethanol, dried in a vacuum oven at 60°C for 12 hours, and calcined at 400°C for 2 hours to obtain a black copper oxide solid. Preparation of modified glassy carbon electrode: Weigh a small amount of the solid, add 0.5% Nafion solution and ethanol solution, ultrasonically disperse it into an ink-like state, apply the dispersed liquid onto the surface of the previously treated glassy carbon electrode, and dry it in the air to ob...

Embodiment 2

[0042] Preparation of a raspberry-shaped copper oxide material and construction of a non-enzymatic glucose sensor, including the preparation of raspberry-shaped copper oxide, the preparation of the raspberry-shaped copper oxide: Weigh 0.1 g P123 and dissolve it in 3.8 mL ethanol, ultrasonic 15 min to dissolve, add 0.399 g copper nitrate and 0.070 g HMT ultrasonic to dissolve to obtain a stable solution, add 46 mL ethylene glycol, high-density ultrasonic 30 min, and react at 200 °C for 24 hours to obtain a precipitate, wash it three times with deionized water, Wash with ethanol three times, dry in a vacuum oven at 60°C for 12 hours, and calcinate the product at 400°C for 2 hours to obtain a black copper oxide solid. Preparation of modified glassy carbon electrode: Weigh a small amount of the solid, add 0.5% Nafion solution and ethanol solution, ultrasonically disperse it into an ink-like state, apply the dispersed liquid onto the surface of the previously treated glassy carbon e...

Embodiment 3

[0044] Preparation of a raspberry-shaped copper oxide material and construction of a non-enzymatic glucose sensor, including the preparation of raspberry-shaped copper oxide, the preparation of the raspberry-shaped copper oxide: Weigh 0.2 g P123 and dissolve it in 3.8 mL ethanol, ultrasonic 15 min to dissolve, add 0.399 g copper nitrate and 0.045 g HMT ultrasonic to dissolve, obtain a stable solution, add 46 mL ethylene glycol, high-density ultrasonic 30 min, and react at 200 ° C for 12 hours to obtain a precipitate. washed three times with ethanol, dried in a vacuum oven at 60°C for 12 hours, and calcined at 400°C for 2 hours to obtain a black copper oxide solid. Preparation of modified glassy carbon electrode: Weigh a small amount of the solid, add 0.5% Nafion solution and ethanol solution, ultrasonically disperse it into an ink-like state, apply the dispersed liquid onto the surface of the previously treated glassy carbon electrode, and dry it in the air to obtain CuO / GCE ...

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Abstract

A copper oxide nonenzymatic glucose electrochemical sensor belongs to the technical field of detection. The invention aims synthesizing a transtition metal oxides CuO nano material by a convenient preparation method in order to build the copper oxide nonenzymatic glucose electrochemical sensor with high sensitivity, wide detection range and low cost. The raspberry-shaped CuO provided by the invention is prepared from the following raw materials of cupric nitrate, ethyl alcohol, P123, HMT and ethylene glycol. The black copper oxide solid is prepared by comprising the steps: dropwise covering black copper oxide solid dispersing solution onto the surface of glassy carbon electrode subjected to pretreatment for later use to serve as a working electrode of the nonenzymatic glucose sensor, forming a three electrode system by combing a saturated calomel electrode serving as a reference electrode and a platinum wire electrode serving as a counter electrode. The accurate glucose detection can be realized, basic data and theoretical support are applied to the industrialization applications of the nonenzymatic glucose sensor. A CuO/GCE electrode has the advantages that selectivity is good, isnot disturbed by crylic acid, ascorbic acid and the like, is not influenced by chloridion in the solution. Therefore, the CuO/GCE electrode has the excellent performance in glucose detection.

Description

technical field [0001] The invention belongs to the technical field of detection. Background technique [0002] Glucose, as one of the main life essential compounds, rapid and convenient detection of its concentration is very important in various fields of social production and life. For example, in the medical field, with the improvement of living standards, the incidence of diabetes has been increasing year after year. Sensitive detection of blood glucose concentration is particularly important for the prevention of diabetes. Therefore, finding a low-cost, high-performance glucose sensor has always been a research hotspot in the field of sensor research. In addition, some industrial wastewater also contains glucose, and the concentration of this type of glucose often needs to be determined. [0003] Glucose electrodes based on biological enzymes have been developed and perfected for more than 50 years, and enzyme glucose sensors have become mature. According to whether t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/327G01N27/30
CPCG01N27/308G01N27/3277G01N27/48
Inventor 孙墨杰王喆王冬杨耀国
Owner NORTHEAST DIANLI UNIVERSITY
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