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Melanin/Ce6 photodynamic nano tumor drug capable of improving light absorption as well as preparation and application of melanin/Ce6 photodynamic nano tumor drug

A technology of tumor drugs and melanin, which is applied in the direction of anti-tumor drugs, drug combinations, medical preparations of non-active ingredients, etc., to achieve the effect of improving the effect, increasing the enrichment, and reducing the skin phototoxicity

Active Publication Date: 2018-05-08
TONGJI UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the usual nano-drug carriers only have the function of drug carriers

Method used

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  • Melanin/Ce6 photodynamic nano tumor drug capable of improving light absorption as well as preparation and application of melanin/Ce6 photodynamic nano tumor drug
  • Melanin/Ce6 photodynamic nano tumor drug capable of improving light absorption as well as preparation and application of melanin/Ce6 photodynamic nano tumor drug
  • Melanin/Ce6 photodynamic nano tumor drug capable of improving light absorption as well as preparation and application of melanin/Ce6 photodynamic nano tumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A preparation method of melanin / Ce6 photodynamic nano-medicine with enhanced heat absorption, comprising the following steps:

[0048]Prepare Ce6 into a high-concentration mother solution of 25mg / ml DMSO, drop it into the melanin aqueous solution (0.5mg / ml) according to a certain ratio (the mass ratio of melanin: Ce6 is 1:2), mix for 8h, and then dialyze in water once 24h, the transmission electron micrograph of the melanin / Ce6 nanoparticle of final gain is as follows image 3 As shown, the measured hydrated particle size distribution is shown in Figure 4 As shown, the particle size of melanin / Ce6 nanoparticles is 20-300nm.

[0049] The ultraviolet absorption curve after the above-mentioned melanin / Ce6 nanoparticle solution is diluted 100 times is as follows image 3 As shown, at wavelengths of 405nm and 645nm, the melanin / Ce6 nanoparticle solution has strong absorption. According to the standard curve, the encapsulation efficiency of Ce6 was calculated to be 50% us...

Embodiment 2

[0062] Compared with Example 1, the preparation process of this example is:

[0063] Prepare Ce6 into a high-concentration mother solution of DMSO at 5 mg / ml, and add it dropwise to the melanin aqueous solution (1.5 mg / ml) according to a certain ratio (the mass ratio of melanin: Ce6 is 1:0.01), mix for 0.5 h, and then Dialyze in water for 6 hours to obtain the nano drug solution.

Embodiment 3

[0065] Compared with Example 1, the preparation process of this example is:

[0066]Prepare Ce6 into a high-concentration mother liquor of 40mg / ml DMSO, and add it dropwise to the melanin aqueous solution (0.01mg / ml) according to a certain ratio (the mass ratio of melanin: Ce6 is 1:40), mix for 24h, and then dissolve in water once After dialysis for 48 hours, the nano drug solution was obtained.

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Abstract

The invention relates to a melanin / Ce6 photodynamic nano tumor drug capable of improving the light absorption as well as preparation and application of the melanin / Ce6 photodynamic nano tumor drug. The nano tumor drug is prepared by virtue of the following method: preparing Ce6 into a DMSO mother solution, dropwise adding the DMSO mother solution into a melanin aqueous solution, mixing, dialyzing,thus obtaining the melanin / Ce6 photodynamic nano tumor drug, wherein a mass ratio of a melanin nano particle carrier to photodynamic drug Ce6 is 1 to (0.01 to 10). After the melanin / Ce6 photodynamicnano tumor drug is injected into a nude mouse body via caudal vein, the enrichment effect on a tumor part is good, in the photodynamic treatment process, the melanin can absorb the energy of the light, the temperature of tissues on a treated part is increased, the photodynamic treatment effect of a photo-sensitizer is improved, and the specific photodynamic treatment effect on local tumor is good;and in addition, the melanin / Ce6 nanometer can further wrap and carry other chemotherapy drugs, photodynamic drugs, photoacoustic probes, nuclear magnetism probes, genes, polypeptides, protein targeting molecules and the like, so that the application prospect is wide.

Description

technical field [0001] The invention relates to a photodynamic nano tumor drug and its preparation and application, in particular to a melanin / Ce6 photodynamic nano tumor drug with enhanced light absorption and its preparation and application. Background technique [0002] At present, the mortality rate of tumors is still high, and the research on tumor therapeutic drugs has received great attention in scientific research work. Various tumor drugs emerge in endlessly, among which nano-medicine is one of the important directions of current research. The method of preparing nano anticancer drugs is to load non-water-soluble, highly cytotoxic anticancer drugs, photothermal and photodynamic drugs, gene drugs or multiple functional drugs into polymers, liposomes, polysaccharides and proteins to form The nano-drugs effectively increase the water solubility, reduce the cytotoxicity, prolong the circulation time in the body, and more effectively enrich the lesion site. Development ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/46A61P35/00
CPCA61K9/5176A61K41/0071
Inventor 刘萍李永勇任天斌董海青
Owner TONGJI UNIV
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