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Multi-spectral three-dimensional imaging system and method

An image and visible light technology, applied in image enhancement, medical image, image analysis, etc., can solve problems such as high cost

Active Publication Date: 2022-03-15
EMIT IMAGING INC
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  • Claims
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Problems solved by technology

Such specificities in a single imaging system can lead to high cost per scan

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  • Multi-spectral three-dimensional imaging system and method
  • Multi-spectral three-dimensional imaging system and method
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[0026] The ability to image the fluorescence distribution of various substances within animals, organs or tissues has proven valuable in drug discovery and development. In vivo fluorescence imaging has proven to be a challenge especially for targets at depth due to the high scattering of optical light in tissue. In vivo bulk fluorescence imaging has been performed using tomographic restoration as well as epi-illumination and trans-illumination schemes. However, fluorescence recovery using these forms of imaging has been shown to have poor accuracy for deeply located and highly absorbing organs such as the liver. Additionally, the resolution limit of in vivo fluorescence recovery is widely believed to be limited at most to a few millimeters due to the ill-posed nature of the fluorescence recovery problem. This type of resolution limit reduces the ability to provide any meaningful fluorescence information on the relevant (eg, vessel's) characteristic length scale levels beyond ...

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Abstract

A computer-implemented method of creating an image of a specimen is disclosed, the method comprising: receiving a first image of a first slice of a specimen, the first image created using invisible light at a first wavelength; receiving the specimen A second image of a second slice of a second slice adjacent to the first slice and the second image created using invisible light of the first wavelength; co-registering the first image and the a second image; and creating, by the processor, a single planar image of the first slice using a next image pass.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application Serial No. 62 / 164,800, filed May 21, 2015, entitled "Multi-Spectral Three Dimensional Imaging System and Method," the entire disclosure of which application is incorporated herein by reference. technical field [0003] The inventive concept relates to imaging, and more particularly, to imaging using light of different wavelengths. Background technique [0004] Multispectral fluorescence cryoslice imaging has previously been used to measure in vitro drug distribution in stand-alone or modified cryoslice imagers [1,2]. Such idiosyncrasies in a single imaging system can result in high costs per scan. For high throughput and low cost, it would be valuable to construct a fluorescence imager with a corresponding software package that can work with common cryosectioning instruments already in place. To this end, the method outlined here demonstrates a versati...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T15/08G01N21/64
CPCG01N21/6456G01N23/046G06T2207/10064G06T2207/10072G06T2207/10152G06T2207/30024A61B5/0073A61B5/0077A61B5/0507A61B5/0536A61B5/055G01N21/6428A61B2503/42A61B2576/00G01N2021/6441G06T7/0012G16H30/40G01N21/645G06T5/003G06T2207/30101G06T2207/10012G06T17/00
Inventor 罗伯特·W·霍尔特穆罕默德·Q·库塔斯约翰·W·霍平马克·E·西曼雅各布·Y·黑斯特曼
Owner EMIT IMAGING INC