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Soluble anesthetic microneedle

A soluble, micro-needle technology, applied in the direction of anesthetics, organic active ingredients, medical preparations of non-active ingredients, etc., can solve the problems of inaccurate dose control, uncontrollable body parts, and harm to patients, so as to expand the safety range and use range, reduce bleeding, and prevent infection

Inactive Publication Date: 2018-05-29
陈彦彪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tablet makes the body part of the anesthetized uncontrollable. In addition, the tablet needs to be absorbed by the patient to exert its effect, but each patient has individual differences in the absorption of the drug. Therefore, the dose cannot be accurately grasped. The patient has completed the operation, but the anesthetic cannot be excreted; if the dose is small, the patient can wake up during the operation, making the patient more painful, which is also a potential harm to the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] The preparation method of the above-mentioned soluble anesthetic microneedle mainly includes the following steps:

[0054] S1: Pulverize Dajinhua, Shengcaowu, Chuanqiong, Tianzhuhuang, Asarum, Lmianzhen, Mint, Toad Su, Panax notoginseng, Angelica, Honeysuckle, Albizia Julibrissin, and Angelica dahurica at room temperature, and pass through a 180-300 mesh sieve , to obtain Dajinhua fine powder, Raw grass black fine powder, Chuanqiong fine powder, Tianzhuhuang fine powder, Asarum fine powder, Liangmianzhen fine powder, mint fine powder, toad powder, Panax notoginseng fine powder, Angelica fine powder Powder, honeysuckle fine powder, Albizia juniper fine powder, Angelica dahurica fine powder, set aside.

[0055] S2: Weigh the datura flower fine powder, raw grass black fine powder, Chuanqiong fine powder, Tianzhuhuang fine powder, asarum fine powder, limpet fine powder, mint fine powder, and toad venom obtained in step S1 in parts by weight Fine powder, Panax notoginseng f...

Embodiment 1

[0062] This embodiment provides a soluble anesthetic microneedle, in parts by weight, the active ingredients include: 15 parts of Yangjinhua, 8 parts of Shengcaowu, 7 parts of Rhizoma Chuanxiong, 5 parts of Tianzhuhuang, 5 parts of Asarum, and 8 parts of Liangmianzhen , 15 parts of mint, 5 parts of toad venom, 12 parts of Panax notoginseng, 5 parts of angelica, 7 parts of honeysuckle, 5 parts of ephedrine, 3 parts of Albizia juniper, and 8 parts of Angelica dahurica.

[0063] The preparation method of the above-mentioned soluble anesthetic microneedle comprises the following steps:

[0064] S1: Pulverize Yangjinhua, Shengcaowu, Chuanqiong, Tianzhuhuang, Asarum, Lmianzhen, Mint, Toad Su, Panax notoginseng, Angelica, Honeysuckle, Albizia Julibrissin, and Angelica dahurica at room temperature, pass through a 240-mesh sieve, and prepare Deyangjinhua fine powder, raw grass black fine powder, Chuanqiong fine powder, Tianzhu yellow fine powder, asarum fine powder, double-faced needle...

Embodiment 2

[0071] This embodiment provides a soluble anesthetic microneedle, in parts by weight, the active ingredients include: 17 parts of Yangjinhua, 10 parts of Aconiti officinalis, 9 parts of Rhizoma Chuanxiong, 6 parts of Tianzhuhuang, 6 parts of Asarum, and 10 parts of Liangmianzhen , 13 parts of mint, 4 parts of toad venom, 10 parts of Panax notoginseng, 6 parts of angelica, 5 parts of honeysuckle, 4 parts of ephedrine, 1 part of acacia bark, and 5 parts of angelica.

[0072] The preparation method of the above-mentioned soluble anesthetic microneedle comprises the following steps:

[0073] S1: Pulverize Yangjinhua, Shengcaowu, Chuanqiong, Tianzhuhuang, Asarum, Lmianzhen, Mint, Toad Su, Panax notoginseng, Angelica, Honeysuckle, Albizia Julibrissin, and Angelica dahurica at room temperature, pass through a 300-mesh sieve, and prepare Deyangjinhua fine powder, raw grass black fine powder, Chuanqiong fine powder, Tianzhu yellow fine powder, asarum fine powder, double-faced needle fi...

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Abstract

The invention discloses a soluble anesthetic microneedle. The microneedle comprises an outer cladding layer and effective ingredients, wherein the effective ingredients comprise, in parts by weight, 13-18 parts of flos daturae, 6-13 parts of radix aconiti, 5-10 parts of rhizoma chuanxiong, 4-8 parts of tabasheer, 4-8 parts of herba asari, 5-12 parts of radix zanthoxyli, 10-16 parts of herba menthae, 3-6 parts of toad venom, 8-14 parts of radix notoginseng, 4-7 parts of radix angelicae sinensis, 4-8 parts of flos lonicerae, 3-7 parts of ephedrine, 1-3 parts of cortex albiziae and 4-9 parts of radix angelicae. The soluble anesthetic microneedle has the advantages as follows: various anesthetics are highly selected and combined optimally on the basis that the anesthetic effect is guaranteed,so that the dosage and toxic and side effects of each medicine are reduced, the safe range and the use range of the soluble anesthetic microneedle are enlarged, and the best anesthetic technique is provided under the condition of minimum interference to physiological activities of bodies; postoperative bleeding can be reduced and infection can be prevented; the soluble anesthetic microneedle is biodegradable, can be completely dissolved or degraded to release inside effective ingredients and has a certain slow release effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and pharmacy, and in particular relates to a soluble anesthetic microneedle. Background technique [0002] Anesthesia is a variety of methods used to eliminate pain, ensure patient safety, and create good surgical conditions during operations or diagnostic inspections. It mainly includes three types: local anesthesia, regional anesthesia, and general anesthesia. Local anesthesia is the mildest type and numbs only a small area, such as a single tooth. Regional anesthesia is the injection of drugs into the spine to block nerve signals to the brain, thereby rendering a larger area of ​​the patient unconscious. Often, patients receiving regional anesthesia are also given a smaller dose of a strong sedative drug, such as propofol—a dose that does not render the patient completely unconscious, but enough to alter brain activity so that the patient is less aware and less responsive ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/00A61K47/36A61P23/00A61K35/65A61K31/137
CPCA61K36/899A61K9/0021A61K31/137A61K35/65A61K36/232A61K36/236A61K36/258A61K36/268A61K36/355A61K36/48A61K36/534A61K36/714A61K36/758A61K36/81A61K47/36A61K2236/333A61K2300/00
Inventor 唐骢
Owner 陈彦彪
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