18 results about "Zanthoxylum nitidum" patented technology

The application discloses a traditional Chinese medicine composition for treating pancreatic cancer, which comprises the following medicinal materials in parts by weight: 1-20 parts of Chinese cork tree, 1-15 parts of ginkgo, 1-10 parts of evodia, 1-10 parts of tripterygium, 1-15 parts of two-edged needle, 1-15 parts of radix astragali, and 1-10 parts of jujube. The application further discloses a medicine taking the traditional Chinese medicine composition as raw materials and a preparation method of the medicine. In addition, the application further discloses application of the traditional Chinese medicine composition or the medicine in preparation of a medicine for treating pancreatic cancer.

The invention discloses all-traditional Chinese medicine traumatic injury medicinal liquor and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of rubus suavissimus, 35-45 parts of ventilago leiocarpa benth, 25-35 parts of fructus schisandrae chinensis, 12-18 parts of asarum sieboldii, 35-45 parts of semiliquidambar cathayensis, 35-45 parts of entada phaseoloides, 17-23 parts of kadsura pepper stem, 25-35 parts of lindera glauca, 35-45 parts of lysimachia christinae hance, 25-35 parts of angelica sinensis, 25-35 parts of berchemia lineate, 35-45 parts of oxalis, 35-45 parts of radix achyranthis bidentatae, 17-23 parts of artabotrys hexapetalus, 25-35 parts of sappanwood The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 to 45 parts of radix notoginseng, 25 to 35 parts of bodhi, 25 to 35 parts of radix aristolochiae fordianae, 17 to 23 parts of crane knee, 30 to 40 parts of caulis sargentodoxae, 20 to 30 parts of cyathea spinulosa wall, 35 to 45 parts of tinospora sinensis merr, 25 to 35 parts of ardisia punctata, 35 to 45 parts of knottedflower knotweed root, 20 to 30 parts of flos carthami, 35 to 45 parts of cynanchum otophyllum, 25 to 35 parts of schizophragma serratum, 25 to 35 parts of radix cynanchi paniculati and 35 to 45 parts of champion bauhinia root. The traditional Chinese medicine is reasonable and unique in compatibility, remarkable in curative effect and comprehensive in efficacy and gives consideration to exterior and interior.

The application provides a bacteriostatic and lubricating coconut oil-containing composition and a preparation method thereof, which uses virgin coconut oil, coconut oil extract, extract of Zanthoxylum bungeanum Maxim and extract of Ligustrum lucidum Ait as raw materials, the virgin coconut oil is extracted by a supercritical carbon dioxide extraction method, has high extraction rate and high lauric acid content, the virgin coconut oil is extracted, the bacteriostatic effect of the composition can be improved, and meanwhile, the particle size of the finished product can be reduced in the processing process to form a finished product with high stability. In the application, the effective components in Zanthoxylum bungeanum Maxim and Ligustrum lucidum Ait are extracted, which is beneficial to improving the efficacy of the finished product, the extract of Zanthoxylum bungeanum Maxim and the extract of Ligustrum lucidum Ait also have better water absorption and emulsification performance as emulsifiers, and the stability of the finished product is further improved.

The invention discloses a Yao medicine composition with effects of regulating menstruation and stopping bleeding as well as a preparation method and application of the Yao medicine composition, and belongs to the technical field of ethnic medicines. The composition is prepared from paris polyphylla, radix zanthoxyli, giantleaf ardisia rhizome, ovateleaf holly bark, radix fici simplicissimae and callicarpa macrophylla. The preparation method comprises the following steps: carrying out secondary water extraction on the raw materials, concentrating to specified density, standing, precipitating, removing impurities, preparing and the like. The Yao medicine composition disclosed by the invention not only has a remarkable hemostatic effect, but also has an excellent endocrine regulation function. Pharmacodynamic experiments show that in a rat dysfunctional blood model induced by combination of mifepristone and misoprostol, the composition can significantly reduce the bleeding amount and shorten the bleeding time, the hemostatic effect is equivalent to that of a positive control drug, namely Gongxuening capsule and a pure paris polyphylla extract, and although a paris polyphylla preparation exists, the hemostatic effect of the composition is remarkably improved. However, the problem that a single paris polyphylla preparation is weak in FSH / LH regulation capacity is solved, and data prove that the compound is irreplaceable.

The invention discloses a scald ointment for diminishing inflammation and swelling and promoting healing and a preparation method thereof. The emu oil is prepared from the following raw materials: peony seed oil, borage oil, evening primrose oil, perilla seed oil, shea butter, rose hip oil, emu oil, linseed oil, coconut oil, palm oil, horse oil, zedoary turmeric oil, safflower seed oil, pine needle oil, a paniculate spotflower herb alcohol extract, a paniculate spotflower herb water extract, lygodium japonicum, polygonatum polysaccharide, a blackberry lily extracting solution, a jerusalem artichoke extracting solution, a lavender extracting solution and a rhodiola rosea extracting solution. The formula comprises a radix zanthoxyli extracting solution, lanolin, methylparaben, granular paraffin and ethanol. The traditional Chinese medicine composition is natural and mild in components, small in skin irritation, safe to use, capable of deeply permeating, locking moisture, rapid in effect taking and capable of remarkably inhibiting inflammatory response, relieving tissue redness and swelling, shortening the healing period, providing a moist environment for tissue repair, continuously nourishing periinvasive tissue, promoting granulation tissue growth and accelerating the epithelization process, so that damaged skin is effectively repaired; good clinical application prospects and market potential are realized.

The invention provides a nursing traditional Chinese medicine external preparation for relieving rheumatic arthralgia, and relates to the technical field of traditional Chinese medicines. On the basis of the theory of traditional Chinese medicine, a traditional Chinese medicine formula composed of pine nodular branch, ormosia henryi, shinyleaf pricklyash root, peach twig, lance asiabell root, arachnoid cyanotis root, dentiferous dendropanax root, rhizoma curculiginis, winter jasmine, wintergreen, folium cortex eucommiae, semen sesami nigrum, fructus viticis, semen allii tuberosi, rhizoma smilacis glabrae and herba menthae is prepared and used for externally treating rheumatoid arthritis in traditional Chinese medicine. The traditional Chinese medicine has the effects of promoting blood circulation to remove meridian obstruction, relieving swelling and pain, dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, clearing heat and promoting diuresis. The traditional Chinese medicine external preparation disclosed by the invention has excellent anti-inflammatory, detumescence and analgesic effects, has excellent performance in the aspects of improving clinical symptoms such as joint swelling, pain and pressing pain of a patient and improving sleep and joint functions, and takes effect quickly. The traditional Chinese medicine external preparation provides effective nursing means and measures for relieving or relieving rheumatic arthralgia.

The invention discloses a traditional Chinese medicine composition for relieving swelling and pain and a preparation method thereof. The traditional Chinese medicine composition for relieving swelling and pain is prepared from the following raw materials in parts by weight: 40 to 100 parts of radix aucklandiae, 40 to 100 parts of radix saposhnikoviae, 40 to 100 parts of herba schizonepetae, 40 to 100 parts of herba asari, 40 to 100 parts of cortex acanthopanacis, 40 to 100 parts of cassia twig, 40 to 100 parts of radix achyranthis bidentatae, 40 to 100 parts of rhizoma chuanxiong, 40 to 100 parts of radix cynanchi paniculati, 70 to 120 parts of radix angelicae, 40 to 100 parts of rhizoma curcumae, 70 to 120 parts of cortex parabarii, 130 to 180 parts of ardisia quinquefolia, 130 to 180 parts of ardisia crenata, 130 to 180 parts of radix zanthoxyli, 120 to 160 parts of herba fibraureae recisae, 130 to 180 parts of , 30-60 parts of agilawood, 60-100 parts of camphor, and 60-100 parts of menthol. The formula of the traditional Chinese medicine composition for relieving swelling and pain is adjusted, so that the pain relieving effect and the drug effect lasting time are better.

This invention discloses a tetracyclic analogue-sulfonamide hybrid of *Zanthoxylum bungeanum* alkaloids, possessing the following general formula. The invention also provides a method for preparing the tetracyclic analogue-sulfonamide hybrid of *Zanthoxylum bungeanum* alkaloids, comprising dissolving compound 10 or compound 11 and triethylamine in dichloromethane, adding benzenesulfonyl chloride derivative 12a-12e at low temperature, stirring, and then stirring at room temperature until the starting material spot disappears. The reaction is monitored by TLC. After the reaction is complete, the product 13a-13e or 14a-14e is obtained by column chromatography separation and purification. The tetracyclic analogue-sulfonamide hybrid of *Zanthoxylum bungeanum* alkaloids provided by this invention has been shown in in vitro antitumor experiments to exhibit strong inhibitory effects on human cervical cancer cells in leukemia cells, human liver cancer cells, human lung cancer cells, human cervical cancer cells, and normal human liver cells.

This invention relates to a method for increasing the content of chlorobenzanine in tissue culture materials of Zanthoxylum nitidum, belonging to the field of biotechnology. Currently, traditional methods for extracting chlorobenzanine from Zanthoxylum nitidum suffer from problems such as long production cycles and unstable content. To address this, the method provided by this invention includes explant selection, shoot induction culture, cluster shoot culture, callus induction culture, and directed regulation culture. The directed regulation culture involves transferring cluster shoots or callus tissue to red light conditions for 1–2 months, with a light intensity of 150–250 μmol・m⁻²・s⁻¹ and a photoperiod of 10–14 hours / day, to activate the expression of genes involved in the chlorobenzanine synthesis pathway, effectively increasing the chlorobenzanine content.

The invention discloses an antibacterial traditional Chinese medicine hip bath effervescent tablet capable of clearing heat and drying dampness. The effervescent tablet is prepared from traditional Chinese medicine active ingredients, antibacterial ingredients and effervescent auxiliary materials, 1000 tablets are prepared, the weight of each tablet is 0.8 g, and the traditional Chinese medicine active ingredients comprise the following components: 150 g of a radix sophorae flavescentis extract, 120 g of a cortex phellodendri extract, 100 g of a honeysuckle flower extract, 80 g of a dandelion extract, 60 g of a radix zanthoxyli extract and 10 g of borneol. The antibacterial component comprises the following component: 0.20 g of potassium permanganate; and the effervescent auxiliary material comprises the following components: 200g of sodium bicarbonate, 180g of citric acid, 150g of mannitol, 15g of povidone K30 and 5g of magnesium stearate. The invention further discloses a preparation method of the heat-clearing dampness-drying antibacterial traditional Chinese medicine hip bath effervescent tablet. According to the invention, the defects of convenience, curative effect, safety and stability of a traditional Chinese medicine hip bath preparation and an existing traditional Chinese medicine external effervescent tablet in a perianal and vulva local medication scene are overcome.

The invention belongs to the technical field of biological medicine, and discloses a zanthoxylum nitidum-sourced external vesicle, a preparation method and an application in preparation of a medicine for preventing and treating acute lung injury, and the external vesicle with the particle size of 60-100 nm and a lipid bilayer structure is extracted and purified from the root of zanthoxylum nitidum for the first time. The external vesicle can be administered in modes of aerosol inhalation and the like, and shows an excellent curative effect in an acute lung injury model: lung tissue edema and inflammatory cell infiltration can be remarkably relieved, levels of key proinflammatory factors such as IL-6, TNF-alpha, IL-1beta and the like in serum are reduced, macrophages are promoted to be differentiated to an anti-inflammatory M2 type, and the curative effect is remarkable. The treatment effect is better than that of traditional dexamethasone, and the side effect is lower. The invention provides a brand-new, efficient and safe candidate drug and a natural nano treatment strategy for preventing and treating acute lung injury and ARDS.

The invention discloses a traditional Chinese medicine composition for treating arthralgia. The traditional Chinese medicine composition is prepared from honeysuckle stem, Chinese starjasmine stem, caulis sinomenii, kadsura pepper stem, tinospora sinensis merr, radix puerariae, cassia twig, angelica sinensis, radix paeoniae rubra, ligusticum wallichii, notopterygium root, radix angelicae pubescentis, peach kernel, safflower carthamus, radix clematidis, galangal, asarum, cinnamon leaf, radix cynanchi auriculati and radix zanthoxyli. Therefore, the invention further develops a traditional Chinese medicine preparation of the dredging ointment for treating arthralgia, and establishes a corresponding preparation method. According to the traditional Chinese medicine composition disclosed by the invention, the medicinal materials such as the five vines, the notopterygium root, the radix angelicae pubescentis, the peach kernel and the safflower are matched, so that a compound syndrome type of wind-cold-dampness-blood stasis and deep meridian blockage is accurately covered, and is not limited to mild wind-cold arthralgia or pure dampness arthralgia; the application mode of the incense applying method is flexible and convenient, the application position can be adjusted according to the affected part, and the incense applying device has adaptability to various severe arthralgia syndromes such as rheumatic arthritis. Meanwhile, the traditional Chinese medicine composition is simple in preparation process and convenient and safe to use, meets the requirement of long-term conditioning of patients with severe arthralgia syndromes, and overcomes the defects that in the prior art, the use threshold is high, and insistence at home is inconvenient.

The invention discloses a cultivation method for preventing skin diseases of hippocampus kelloggi larvae, and belongs to the technical field of aquaculture. The method comprises the following steps: a bait preparation step: mixing artemia nauplii and copepods to prepare composite bait; disease prevention and management: adding a zanthoxylum nitidum water extract into the water body; and a special bait feeding step: taking the compound bait as a unique bait source for feeding, and preventing skin diseases through a zanthoxylum nitidum aqueous extract during the feeding process. The method solves the technical bottlenecks of low survival rate, abnormal intestinal development, difficulty in domestication and bacterial infection of the hippocampus kelloggi larva in the mouth opening stage. Experiments show that the method can significantly improve the survival rate and growth performance of the hippocampus kelloggi larvae and improve the health state of the hippocampus kelloggi larvae. On one hand, by promoting intestinal development, the digestion and absorption functions and the immune level of the body are effectively improved; on the other hand, common diseases such as skin ulcer and tail rot caused by bacterial infection can be obviously prevented, and a reliable guarantee is provided for healthy breeding of the hippocampus kelloggi.

The external Chinese herbal medicine essential oil combined liquid medicine is characterized by being prepared from the following Chinese herbal medicine essential oil: rhizoma arisaematis, radix zanthoxyli, semen strychni, radix aconiti carmichaeli, herba ephedrae, kadsura pepper stem, rhizoma corydalis, pogostemon cablin, ligusticum wallichii, ginger, radix cynanchi paniculati, artemisia anomala, radix angelicae, melissa officinalis, cinnamon, mint and safflower carthamus. The traditional Chinese medicine has the effects of relaxing tendons and activating collaterals, promoting blood circulation to remove blood stasis and relieving swelling and pain; the traditional Chinese medicine composition has the effects of being high in medicine efficacy permeability, rapid in effect taking and capable of rapidly relieving the illness state, and can be used for preparing external application for treating diabetic eye diseases and heart diseases such as heart diseases, coronary heart diseases, heart discomfort or pain, stuffiness pain, angina pectoris, neck arteriosclerosis, plaques and static arterial thrombosis in cardiovascular and cerebrovascular diseases. The external medicine is used for relieving swelling and pain, soothing channels and activating collaterals, and promoting blood circulation to remove blood stasis. The invention provides a convenient, rapid and effective external medicine treatment mode for patients with the diseases.

The invention relates to the technical field of eye care liquid, and particularly discloses eye care liquid and a preparation method thereof. The eye health-care liquid is prepared from the following raw materials in parts by weight through biological fermentation: 1-6 parts of chrysanthemum, 1-6 parts of semen cassiae, 1-5 parts of ginseng, 1-6 parts of radix zanthoxyli, 1-5 parts of cinnamon, 1-10 parts of red dates, 1-5 parts of cassia twig, 1-6 parts of safflower, 1-8 parts of white poria, 1-4 parts of radix saposhnikoviae, 1-8 parts of angelica sinensis, 1-5 parts of ligusticum wallichii and 1-6 parts of radix paeoniae alba. The traditional Chinese medicine composition has the beneficial effects that the composition is high in synergism, the compatibility of monarch, minister, assistant and guide is rigorous aiming at the core pathogenesis of eye diseases such as deficiency of liver and kidney, deficiency of qi and blood and blood stasis and wind heat, and multi-target comprehensive conditioning is realized. A fermentation process under specific conditions is adopted, compared with traditional water decoction or alcohol extraction, the active ingredients are richer, the molecular weight is smaller, transdermal absorption is easier, the bioavailability is remarkably improved, and damage of high temperature to heat sensitive ingredients is avoided.

This invention discloses a fingerprint quality control method for a compound *Zanthoxylum nitidum* composition, comprising gradient elution and determination using high-performance liquid chromatography (HPLC). The HPLC conditions are: column: C18 column; detection wavelength: 250 nm; mobile phase: mobile phase A is methanol, and mobile phase B is a 0.1% triethylamine solution containing 0.1% formic acid by weight, using gradient elution. This invention establishes the HPLC fingerprint of the compound *Zanthoxylum nitidum* composition through optimized chromatographic conditions and sample preparation methodology. This method is simple to operate, accurate, and has good repeatability, and can effectively control the quality consistency of the compound *Zanthoxylum nitidum* composition.

The invention provides a traditional Chinese medicine composition for treating chronic rhinitis and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of flos chrysanthemi indici, 10 to 30 parts of fructus xanthii, 3 to 10 parts of spica prunellae, 5 to 15 parts of radix gentianae, 10 to 20 parts of herba pogostemonis, 5 to 15 parts of radix zanthoxyli and 3 to 10 In the formula, wild chrysanthemum is used as a monarch drug to dispel wind and heat, diminish inflammation and detoxify; the wrinkled gianthyssop herb can relieve exterior syndrome, eliminate dampness, regulate qi and harmonize the middle warmer, and the cocklebur fruit can relieve stuffy nose and dispel wind-cold; zanthoxylum nitidum, selfheal, codonopsis pilosula and radix gentianae are used as adjuvant drugs together to help the monarch drug wild chrysanthemum flower to diminish inflammation and clear away heat and toxic materials and enhance the effects of tonifying qi and strengthening spleen, enhancing transportation and transformation functions of the spleen, supporting defensive qi, enhancing immunity, preventing exogenous evil invasion and regenerating damp turbidity, and the seven drugs are combined together to achieve the effect.

The invention relates to a preparation method of radix zanthoxyli protoplast, and belongs to the technical field of plant biology. The method aims to solve the technical problem that the whole protoplast is difficult to release by a conventional enzymolysis method due to high cell wall lignification degree and compact tissue structure when the radix zanthoxyli is used as a woody vine plant. According to the technical scheme, the method comprises the steps of culturing zanthoxylum nitidum seedlings; selecting terminal buds and tender leaves below the terminal buds, performing low-temperature dark pretreatment, and shredding; soaking the leaf filaments in an enzymatic hydrolysate which is based on a CPW solution and contains mannitol, cellulase R-10, pectinase Y-23 and macerozyme R-10, carrying out vacuum-pumping treatment, and carrying out constant-temperature oscillation enzymolysis; and after enzymolysis, the protoplast is obtained through the steps of filtration, centrifugation and resuspension purification. The prepared protoplast can be used for somatic cell hybridization, genetic transformation and single cell level research.