A kind of itraconazole drops and preparation method thereof
An itraconazole drop and the technology of itraconazole, applied in the field of itraconazole drop and its preparation, can solve the problems of significant individual differences in bioavailability and immature physiological functions of the gastrointestinal tract of infants and young children, etc.
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Embodiment 1
[0014] Material composition Prescription ratio (g) Itraconazole 3 Vitamin E Acetate 80 Vitamin A1 5 PEG400 10
[0015] Preparation method: 1) Itraconazole is crushed through a 150-mesh sieve, and fully mixed with PEG400; 2) Vitamin E acetate and vitamin A1 are fully mixed; 3) The mixture of step 1) is slowly added to the mixture of step 2), Add while stirring on high speed until fully combined and dissolved. 4) Subpackaged as itraconazole 100mg / bottle.
Embodiment 2
[0017] prescription:
[0018]
[0019]
[0020] Preparation method: 1) Itraconazole is pulverized through a 100-mesh sieve, and fully mixed with PEG400; 2) Vitamin E acetate, vitamin A1 and butylated hydroxyanisole are fully mixed; 3) The mixture in step 1) is slowly added to step 2 ) mixture, add while stirring at high speed until completely mixed and dissolved. 4) Subpackaged as itraconazole 100mg / bottle.
Embodiment 3
[0022] Material composition Prescription ratio (g) Itraconazole 1 Vitamin E Acetate 90 Vitamin A1 9 PEG400 20 Propylparaben 1 2,6-di-tert-butyl-p-cresol 1
[0023] Preparation method: 1) under a nitrogen-filled environment, itraconazole is pulverized through a 100-mesh sieve, and fully mixed with PEG400; 2) under a nitrogen-filled environment, vitamin E acetate, vitamin A1 and preservatives are fully mixed evenly; 3) filled with Under nitrogen environment, slowly add the mixture of step 1) into the mixture of step 2), and stir at high speed while adding, until completely mixed and dissolved. 4) Subpackaged as itraconazole 100mg / bottle.
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