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Preparation method of shape memory polyurethane micro-nano capsules and its driving method

A driving method, polyurethane technology, applied in the field of functional polymers, can solve the problems that cannot be used to control the drug release rate, drug delivery to target organs, and the inability to achieve effective packaging of drug molecules, etc., to achieve large deformation and shape recovery speed Fast and simple preparation method

Active Publication Date: 2018-06-12
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many reports on the method of making shape memory polymers with micro-nanofiber structure by electrospinning, in the field of biomedicine, shape-memory micro-nanofibers cannot achieve effective encapsulation of drug molecules, and thus cannot be used to control the release rate of drugs. and deliver the drug to the target organ; most of the existing drug carriers have a fixed shape, such as microcapsules, microspheres, etc., and cannot change the shape through the narrow channel. Therefore, the creators of the present invention finally passed through long-term research and practice. obtained the invention

Method used

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  • Preparation method of shape memory polyurethane micro-nano capsules and its driving method

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Embodiment 1

[0029] This embodiment provides a method for preparing shape-memory polyurethane micro-nanocapsules and its thermal driving method, which specifically includes the following steps:

[0030] 1. The isocyanate Soluble in the oil phase system of dioctyl terephthalate, stir at room temperature until completely dissolved to obtain an isocyanate solution; dissolve polyethylene glycol (molecular weight 4000) in the water phase system, the water phase system is polyvinyl alcohol (PVA) (86%-89% degree of polymerization, medium molecular weight) an aqueous solution with a mass concentration of 0.1%-5%, stirred at room temperature until uniformly dispersed to obtain a polyethylene glycol solution.

[0031] 2. Pour the isocyanate solution and polyethylene glycol solution obtained in step 1 into a beaker according to the molar ratio of isocyanate to polyethylene glycol 2:1, and stir for 5 minutes at a speed of 10,000 rpm to obtain a uniform emulsion; Pour it into a three-necked flask, pu...

Embodiment 2

[0036] This embodiment provides another method for preparing shape-memory polyurethane micro-nanocapsules and its thermal driving method, which specifically includes the following steps:

[0037] 1. The isocyanate Soluble in the oil phase system of dioctyl terephthalate, stir at room temperature until completely dissolved to obtain an isocyanate solution; dissolve polyethylene glycol (molecular weight 4000) in the water phase system, the water phase system is polyvinyl alcohol (PVA) (86%-89% degree of alcoholysis, medium degree of polymerization) an aqueous solution with a mass concentration of 0.1%-5%, stirred at room temperature until uniformly dispersed to obtain a polyethylene glycol solution.

[0038]2. Pour the isocyanate solution and polyethylene glycol solution obtained in step 1 into a beaker according to the molar ratio of isocyanate to polyethylene glycol 2:1, and stir for 5 minutes at a speed of 10,000 rpm to obtain a uniform emulsion; Pour it into a three-necked...

Embodiment 3

[0043] This embodiment provides another method for preparing shape-memory polyurethane micro-nanocapsules and its thermal driving method, which specifically includes the following steps:

[0044] 1. The isocyanate Soluble in the oil phase system of dioctyl terephthalate, stir at room temperature until completely dissolved to obtain an isocyanate solution; dissolve polyethylene glycol (molecular weight 4000) in the water phase system, the water phase system is polyvinyl alcohol (PVA) (86%-89% degree of alcoholysis, medium degree of polymerization) an aqueous solution with a mass concentration of 0.1% to 5%, stirred at room temperature until uniformly dispersed to obtain a polyethylene glycol solution;

[0045] 2. Pour the isocyanate solution and polyethylene glycol solution obtained in step 1 into a beaker according to the molar ratio of isocyanate to polyethylene glycol 6:1, and stir for 5 minutes at a speed of 5000 rpm to obtain a uniform emulsion; Pour it into a three-neck...

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Abstract

The invention discloses a preparation method of shape memory polyurethane micro-nano capsules and its driving method. The preparation method particularly includes steps of dissolving isocyanate in anoil phase system to obtain isocyanate solution, dissolving polyethylene glycol in a water phase system to obtain polyethylene glycol solution; mixing the obtained isocyanate solution with the polyethylene glycol solution, stirring to obtain uniform emulsion; heating in an oil bath at 60 DEG C for 20 minutes; adding catalyst and chain extender, heating to 85 DEG C and keeping for 1.5 hours; coolingunder room temperature to obtain shape memory polyurethane micro-nano capsule turbid liquid solution; layering after placing for 24 hours, taking out the shape memory polyurethane micro-nano capsulegrain; washing by distilled water and then centrifugally separating; and then drying to obtain the dispersed shape memory polyurethane micro-nano capsule granular powder. Compared with the prior art,a shell layer with deformable property can enter a narrow channel according to a preset shape, and then a target position is reached, the function is realized.

Description

technical field [0001] The invention relates to the field of functional polymers, in particular to a preparation method of shape-memory polyurethane micro-nano capsules and a driving method thereof. Background technique [0002] At present, shape memory polymers, as an actively deformable smart material, play an important role in people's clothing, food, housing, and transportation. Devices and other fields have received extensive attention. [0003] With the development and progress of science and technology, many fields have higher and higher requirements for micro-nano-scale structural parts. How to prepare small-sized functional devices is a challenge to the preparation technology. At present, shape memory polymers can be used to prepare micro-nanofibrous structures by electrospinning. As disclosed in Chinese patent application CN 104562272A (published date 20150429), the electrospinning method is used to assemble polycaprolactone polyol-based polyurethane micro / nano f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14
CPCB01J13/14
Inventor 张风华冷劲松刘彦菊斯托杨·斯莫科夫
Owner HARBIN INST OF TECH
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