Flexible sensing bacteriostatic dressing capable of monitoring wound surface healing and preparation method thereof

A wound healing and sensing technology, applied in adhesive dressings, non-adhesive dressings, dressings, etc., can solve the problems of occupation of medical resources, persistent wound healing, and difficult wound healing, and achieve pain relief, physical bacteriostatic effect and drug resistance. Sex, the effect of accelerating wound healing

Inactive Publication Date: 2018-06-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the problem of chronic wound healing is particularly prominent. Wounds are protracted, their etiology is complex, and the course of disease is long. It has become an urgent problem to be paid attention to and solved in clinical medicine. Dressings need to be changed frequently, and accidental exposure to infection can make wounds more difficult to heal; and a large number of monitoring facilities are required to evaluate wounds, occupying medical resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of the flexible sensing bacteriostatic dressing capable of monitoring wound healing comprises the following steps:

[0031] (1) Add 25 mg of silver nanowires (AgNWs) and 500 mg of single-layer graphene oxide (GO) into 70 g of absolute ethanol, and disperse ultrasonically at a constant temperature of 25 °C for 30 min to prepare a dispersion based on a synergistically dispersed network structure;

[0032] (2) Completely immerse the polyurethane (PU) sponge matrix in the dispersion prepared in step (1) for 1 min, then dry at room temperature for 5 h;

[0033] Repeat the operation of step (2) 15 times to obtain a dressing loaded with nanomaterials;

[0034] (3) Place the dressing loaded with nanomaterials in a 2 mg / mL dopamine solution with a pH of 9, and stir in water at 60°C for 24 hours for reduction reaction. The nano-filler and excess polydopamine obtained the flexible sensing bacteriostatic dressing that can monitor wound healing.

[0035] The pressu...

Embodiment 2

[0037] The preparation of the flexible sensing bacteriostatic dressing capable of monitoring wound healing comprises the following steps:

[0038] (1) 500 mg of silver nanoparticles (AgNPs) and 25 mg of amino-functionalized graphene oxide (GO) were added to 70 g of deionized water (DI), and ultrasonically dispersed at a constant temperature of 25 ° C for 30 min to prepare a dispersion based on a synergistic dispersion network structure;

[0039] (2) Completely immerse the silicone rubber (PDMS) sponge matrix in the dispersion prepared in step (1) for 2 minutes, then dry at room temperature for 4 hours;

[0040] Repeat the operation of step (2) 10 times to obtain a dressing loaded with nanomaterials;

[0041] (3) Place the dressing loaded with nanomaterials in a 1 mg / mL dopamine solution with a pH of 8.5, and stir in water at 70°C for 20 hours for reduction reaction. The nano-filler and excess polydopamine obtained the flexible sensing bacteriostatic dressing that can monitor ...

Embodiment 3

[0044] The preparation of the flexible sensing bacteriostatic dressing capable of monitoring wound healing comprises the following steps:

[0045] (1) Add 20 mg of zinc oxide rice noodles (ZNONWs) and 150 mg of single-layer graphene oxide (GO) into 40 g of absolute ethanol, and disperse ultrasonically at a constant temperature of 25 ° C for 30 min to prepare a dispersion based on a synergistic dispersed network structure;

[0046] (2) Completely immerse the polyvinyl alcohol (PVA) sponge matrix in the dispersion liquid prepared in step (1) for 3 minutes, then dry at room temperature for 3 hours;

[0047] Repeat the operation of step (2) 20 times to obtain a dressing loaded with nanomaterials;

[0048] (3) Place the dressing loaded with nanomaterials in a 1.5 mg / mL dopamine solution with a pH of 8, and stir in water at 90°C for 18 hours for reduction reaction. The loaded nano filler and excess polydopamine obtain the flexible sensing bacteriostatic dressing that can monitor wo...

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Abstract

The invention discloses a flexible sensing bacteriostatic dressing capable of monitoring wound surface healing and a preparation method thereof. The method comprises the steps that a flexible substrate is dipped in synergetic dispersion containing a zero-dimensional or one-dimensional conductive bacteriostatic nanomaterial and a two-dimensional graphene nanomaterial with a bacteriostatic functionby adopting a dipping method, and after assembly is conducted, reduction is conducted on graphene oxide by using dopamine polymerization to produce the flexible sensing bacteriostatic dressing capableof monitoring wound surface healing. By means of the dressing, a damage wound surface is protected under the situation that the dressing does not need to change to achieve real-time monitoring of thewound surface, physical bacteriostatic effect is achieved and drug resistance is not generated, comprehensive and accurate information can be provided for medical workers in clinical application to relieve the pain of a patient and accelerate the healing of the wound surface, powerful support is provided for customized and accurate medical treatment, the preparation method of the bacteriostatic dressing is simple, the dressing has great significance in meeting clinical demands and solving the problem faced by the implementation of the clinical dressing, and the medical demands which cannot bemet by an existing clinical dressing are solved.

Description

technical field [0001] The invention relates to the technical field of clinical dressing preparation, in particular to a flexible sensing antibacterial dressing capable of monitoring wound healing and a preparation method thereof. Background technique [0002] Wound healing involves many influencing factors and the process is complex. These influencing factors include the patient's age, nutritional status, blood circulation status and function, such as direct influence factors of infection, obesity or diabetes. Combining the above factors, the local temperature and bacterial infection are often concentrated on the wound surface. When these local indicators are controlled within a reasonable range, a good healing environment will be provided for the wound. Among them, the problem of chronic wound healing is particularly prominent. Wounds are protracted and unhealed. The etiology is complex and the course of disease is long. Dressings need to be changed frequently, and accid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/46A61L15/42A61L15/18A61L15/26
CPCA61F13/00008A61F13/00029A61F13/00034A61F13/00051A61F13/00063A61F13/00987A61F13/02A61L15/18A61L15/26A61L15/42A61L15/46A61L2300/102A61L2300/104A61L2300/108A61L2300/404A61L2300/45
Inventor 刘岚董旭初王萍萍郑荣敏刘海州邓智富
Owner SOUTH CHINA UNIV OF TECH
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