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Method for establishing draba nemorosa pulse-activating oral liquid composition fingerprint spectrum

A technology for fingerprinting and establishing methods, applied in the field of traditional Chinese medicine pharmaceutical analysis, can solve the problem of no relevant reports, and achieve the effect of effective product quality

Active Publication Date: 2018-06-29
HEBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no relevant report on the composition confirmation and map establishment of Tingli Shengmai oral medicine such as Tingli Shengmai Oral Liquid

Method used

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  • Method for establishing draba nemorosa pulse-activating oral liquid composition fingerprint spectrum
  • Method for establishing draba nemorosa pulse-activating oral liquid composition fingerprint spectrum
  • Method for establishing draba nemorosa pulse-activating oral liquid composition fingerprint spectrum

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Embodiment 1

[0024] The establishment of embodiment 1 fingerprint

[0025] HPLC conditions: YMC J'sphere ODS-H80-C18 (4.6mm×250mm, 4μm), the mobile phase is acetonitrile (A)-mass percentage 0.5% phosphoric acid (B), gradient elution is: 0- 15min, 15%-21%A; 15-35min, 21%-26%A; 35-50min, 26%-34%A; 50-70min, 34%-61%A; 70-85min, 61%-75 %A; 85-90min, 75%-95%A; 90-100min, 95%-100%A, flow rate 1.0mL·min-1, column temperature 30℃, injection volume 30μL. The detection wavelength is 203nm, 270nm, and the volume percentage of acetonitrile in each time period of the total mobile phase in the above gradient elution process increases at a uniform speed. That is, the following table:

[0026]

[0027] 1.1 Preparation of reference solution

[0028] Accurately weigh the appropriate amount of ginsenoside Rg1, ginsenoside Rb1, tanshinone ⅡA, cryptotanshinone, salvianolic acid B, hydroxysafflower pigment A, schisandrin A, and astragaloside IV reference substances, put them in a 5mL measuring bottle, add...

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Abstract

The invention relates to a method for establishing a draba nemorosa pulse-activating oral liquid composition fingerprint spectrum and belongs to the technical field of traditional Chinese medicine pharmaceutical analysis. The method provided by the invention adopts a high performance liquid chromatography method, and the chromatographic conditions are that the flow velocity is 1.00 ml / ml and the column temperature is 30 DEG C; and a detection instrument adopts an ultraviolet-visible spectroscopic detector, and a flowing phase is subjected to gradient elution by taking an acetonitrile-0.1 percent phosphoric acid solution as a system. The fingerprint spectrum can comprehensively reflect the quality information of the draba nemorosa pulse-activating oral liquid composition, so that the quality of the draba nemorosa pulse-activating oral liquid composition preparation product can be controlled comprehensively and effectively.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmaceutical analysis, and in particular relates to the establishment of fingerprints of Tingli Shengmai Oral Liquid. Background technique [0002] Congestive heart failure (CHF for short) refers to a clinical syndrome in which cardiovascular disease develops to a certain degree and the heart decompensates. According to the World Health Organization, cardiovascular disease is the disease with the highest mortality rate in the world today, accounting for 40% of the total death toll. Tingli Shengmai Prescription is an empirical formula summed up by Xing Yuepeng, a famous old Chinese doctor in the country, based on years of clinical experience in the treatment of CHF with qi deficiency, blood stasis, and yang deficiency with water stagnation. It has been clinically proven to effectively relieve symptoms of patients, improve quality of life, and reduce hospitalization time . ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李春花李佳佳顿佳颖郑鹏
Owner HEBEI UNIV OF CHINESE MEDICINE
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