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Sensor interface for single-use containers

A sensor interface, one-time technology, applied in the direction of instruments, biochemical instruments, measuring instrument components, etc., can solve problems such as inaccurate measurement values

Active Publication Date: 2018-07-03
ROSEMOUNT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods can lead to inaccurate measurements, which are often unacceptable for the life science industry used to support various biological responses

Method used

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  • Sensor interface for single-use containers
  • Sensor interface for single-use containers
  • Sensor interface for single-use containers

Examples

Experimental program
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Embodiment Construction

[0014] Embodiments of the invention generally utilize polymeric sensor interfaces that connect disposable containers, such as bioreactors, to high precision reusable pressure measurement instruments. Accordingly, the actual sensor for measuring the pressure in the bioreactor vessel is provided in a high-precision pressure measuring instrument. In some embodiments, the remote containment system is formed from a polymeric material that is pre-sterilized and can be physically connected to a pre-sterilized single-use bioreactor. In other embodiments, the polymer sensor interface can be directly connected to a reusable measurement instrument such as a pressure transmitter. Accordingly, the bioreactor as well as the polymer sensor interface are disposable. This allows the use of a precise and accurate reusable pressure transmitter, but still provides the end user with a pre-sterilized connection to the bioreactor vessel. The fieldwork instrument side and process side couplings wil...

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PUM

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Abstract

A single-use sensor interface for coupling a single-use container to a re-usable sensing instrument is provided. The single-use sensor interface includes a polymeric flange couplable to a wall of thesingle-use container. The polymeric flange has a sidewall and an interface portion configured to receive a deflectable polymeric diaphragm. A deflectable polymeric diaphragm is coupled to the interface portion of the polymeric flange. An instrument coupling portion is sealingly coupled to the polymeric flange. The instrument coupling portion is configured to couple to the re-usable sensing instrument. Another single-use sensor interface for coupling a single-use container to a re-usable sensing instrument includes a polymeric hose adapter and at least one instrument attachment portion. The polymeric hose adapter portion has at least one hose barb configured to retain a hose slid thereover. The hose adapter portion has at least one interface portion that is configured to receive a deflectable polymeric diaphragm. A deflectable polymeric diaphragm is coupled to the interface portion. At least one instrument attachment portion is coupled to the hose adapter portion. The at least one instrument attachment portion has a cylindrical sidewall.

Description

Background technique [0001] Disposable containers such as bioreactors are used to generate and support biological reactions for any purpose. Biological reactions can be susceptible to changes in temperature and / or pressure. Furthermore, as the biological reaction proceeds, the reaction itself can change various parameters in the bioreactor, such as pressure. Accordingly, it is important to monitor stress or other variables of biological response. [0002] The life sciences industry is transitioning from large, capital-intensive facilities made of stainless steel with large clean-in-place (CIP) infrastructure to smaller facilities using polymeric bags or containers used as bioreactors. The bioreactor bag is used once and then discarded. This single-use bioreactor technology significantly reduces the capital cost of equipment. For example, in existing equipment using stainless steel CIP infrastructure, up to 90% of the cost of operating the equipment may be due to the clean-...

Claims

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Application Information

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IPC IPC(8): G01D11/00G01L19/00
CPCG01D11/00G01L19/00C12M23/28C12M23/46C12M41/40
Inventor 保罗·R·法戴尔乔舒亚·M·普赖斯
Owner ROSEMOUNT INC
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