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Drug composition for preventing and curing diseases related to insulin resistance and preparation method thereof

A technology of insulin resistance and composition, which is applied in the field of pharmaceutical composition and its preparation for the prevention and treatment of insulin resistance-related diseases, which can solve problems such as unfavorable quality control and production, high cost and safety hazards, and unclear pharmacological mechanism, and achieve beneficial The effect of quality control, remarkable effect, and convenient clinical application

Inactive Publication Date: 2018-07-06
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drug described in this patent application contains two traditional Chinese medicines, Coptidis Rhizoma and Cinnamon, the prescription of this drug is not only large, with as many as 16 herbs, but also the properties of the drug overlap, the pharmacological mechanism is unclear, and the cost and safety hazards are high, which is not conducive to Effective quality control and production

Method used

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  • Drug composition for preventing and curing diseases related to insulin resistance and preparation method thereof
  • Drug composition for preventing and curing diseases related to insulin resistance and preparation method thereof
  • Drug composition for preventing and curing diseases related to insulin resistance and preparation method thereof

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Embodiment 1

[0035] 1. An embodiment of the pharmaceutical composition for preventing and treating insulin resistance-related diseases of the present invention, the preparation raw materials of the pharmaceutical composition include the following components: 50 g of cinnamon volatile oil and 50 g of berberine.

[0036] 2, the preparation method of above-mentioned pharmaceutical composition:

[0037] (1) Get the cinnamon volatile oil and extract it with carbon dioxide supercritical extraction or steam distillation to obtain the cinnamon volatile oil extract; take β-cyclodextrin by weighing 15% of the cinnamon volatile oil weight, put it in a container, add purified water, and put it in a boiling water bath Heat to dissolve, place at 50°C, stir at constant temperature for 30 minutes, slowly inject cinnamon volatile oil extract into β-cyclodextrin, continue stirring at constant temperature for 50 minutes, take it out, cool to 25°C, quickly filter, and use it first After washing with a small a...

Embodiment 2

[0041] 1. An embodiment of the pharmaceutical composition for preventing and treating insulin resistance-related diseases of the present invention. The raw materials for the preparation of the pharmaceutical composition include the following components: 34g of cinnamon volatile oil and 66g of berberine.

[0042] 2, the preparation method of above-mentioned pharmaceutical composition:

[0043] (1) Get the cinnamon volatile oil and extract it with carbon dioxide supercritical extraction method or steam distillation to obtain the cinnamon volatile oil extract; take β-cyclodextrin by weighing 12% of the cinnamon volatile oil weight, put it in a container, add purified water, and put it in a boiling water bath Heat to dissolve, place at 37°C, stir at constant temperature for 20 minutes, slowly inject cinnamon volatile oil extract into β-cyclodextrin, continue stirring at constant temperature for 35 minutes, take it out, cool to 25°C, quickly filter, and use it first After washing w...

Embodiment 3

[0047] 1. An embodiment of the pharmaceutical composition for preventing and treating insulin resistance-related diseases of the present invention. The raw materials for the preparation of the pharmaceutical composition include the following components: 66g of cinnamon volatile oil and 34g of berberine.

[0048] 2, the preparation method of above-mentioned pharmaceutical composition:

[0049] (1) Get the cinnamon volatile oil and extract it with carbon dioxide supercritical extraction or steam distillation to obtain the cinnamon volatile oil extract; take β-cyclodextrin by weighing 13% of the cinnamon volatile oil weight, put it in a container, add purified water, and put it in a boiling water bath Heat to dissolve, place at 40°C, stir at constant temperature for 25 minutes, slowly inject cinnamon volatile oil extract into β-cyclodextrin, continue to stir at constant temperature for 40 minutes, take it out, cool to 25°C, quickly filter, and use it first After washing with a sm...

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Abstract

The invention discloses a drug composition for preventing and curing diseases related to insulin resistance. The drug composition is prepared from the following raw materials of, in percentage contentby mass, 10-90% of cortex cinnamomi volatile oil and 10-90% of berberine. The invention further discloses a preparation method of the drug compound. The drug compound selects the cortex cinnamomi volatile oil and berberine to be compatible mutually, the cortex cinnamomi volatile oil and berberine complement each other, the insulin resistance index can be obviously declined, the insulin sensitivity detection index is increased, the glucose area under the curve (AUC) in a glucose tolerance test is effectively reduced, weight gain and fat accumulation caused by insulin resistance are lowered, the sugar content of blood is cut down, the insulin resistance is improved, and the drug composition can be used for preventing and curing diseases with the insulin resistance being the pathophysiological basis. The drug flavor is less, thus quality control is facilitated, meanwhile, the drug is simple, the efficacy is specific, and the effect on preventing and curing the diseases with the insulin resistance being the pathophysiological basis is very outstanding as well.

Description

technical field [0001] The invention relates to a medicine for treating diabetes, in particular to a medicine composition for preventing and treating diseases related to insulin resistance and a preparation method thereof. Background technique [0002] Insulin resistance (Insulin resistance, IR) refers to the reduction of the biological effect of insulin in the blood, that is, a state in which the body's responsiveness to the biological regulation of insulin is reduced, and insulin's ability to promote glucose uptake is impaired, resulting in increased compensatory insulin secretion. , and its important sign is hyperinsulinemia, which is manifested as a decrease in the sensitivity of peripheral tissues to insulin and an obstacle to the utilization of glucose. Insulin resistance is the common pathophysiological basis of many diseases of metabolic syndrome, such as obesity, hyperglycemia, type 2 diabetes, hyperlipidemia, coronary heart disease, hypertension, atherosclerotic co...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K47/69A61P5/50A61P3/04A61P3/10A61P3/06A61P3/00A61P9/12A61K31/4375
CPCA61K31/4375A61K36/54A61K2236/331A61K2236/37A61K2300/00
Inventor 赵晓山罗仁周琳黄沁孙晓敏马柯刘艳艳陈洁瑜陈泽伟卢汉祺游艳婷
Owner SOUTHERN MEDICAL UNIVERSITY
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