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Application of epigallocatechin gallate

A technology of epigallocatechin and gallate, applied in the field of medicine, can solve the problems of inconvenient use, inability to be widely used and the like

Inactive Publication Date: 2018-07-13
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Local UV irradiation treatment is only effective for the itching associated with some diseases, and it is inconvenient to use and cannot be widely used

Method used

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  • Application of epigallocatechin gallate
  • Application of epigallocatechin gallate
  • Application of epigallocatechin gallate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Effect of EGCG in histamine-dependent and histamine-independent models of acute itch

[0026] 1. Observation experiment of itching behavior

[0027] Shave the neck of the ICR mice more than 2 days before the experiment. On the day of behavioral testing, each mouse was individually placed in a plexiglass box (10 x 10 x 12.5 cm) on an elevated wire mesh for at least 30 min to acclimate to the experimental environment. Under the anesthesia of isoflurane, 50 μl reagent (48 / 80 is the stimulating agent induced by the acute itch model dependent on histamine, and CQ is the stimulating agent induced by the acute itching model independent of histamine) was injected intradermally into the neck of the mouse to produce mold. Then set up normal saline group, intraperitoneal injection group (50-200mg / kg) and subcutaneous injection group (50-200μg) of EGCG with different concentrations of EGCG, and observe the changes in the itching behavior of each group, that is, the num...

Embodiment 2

[0032] Example 2: Effect of EGCG in psoriasis chronic itching model

[0033] The ICR mice were randomly divided into three groups, one group was smeared with imiquimod cream and injected with normal saline (Psoriasis+Saline group), and one group was smeared with imiquimod cream and injected EGCG (200mg / Kg, Psoriasis+Saline group) intraperitoneally. EGCG group), and the other group only did hair removal treatment without smearing drugs (Control group), with 5 mice in each group. Fluorescent quantitative PCR, HE staining and other techniques were used to detect the expression of IL-23 in the skin of psoriasis chronic itching model mice. expression, changes in keratinocyte proliferation; using the detection method in Example 1 to study the scratching response of mice after smearing imiquimod cream; using fluorescent quantitative PCR to detect the expression of TRPV1 in the DRG of mice, and taking the neck section at the same time The expression changes of p-ERK and p-ERK were det...

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Abstract

The invention relates to the technical field of medicines and discloses novel application of epigallocatechin gallate in various fields. The invention provides the novel application of the epigallocatechin gallate in various fields mainly focus on treating skin itch, so that a novel treatment means and way is provided for the diseases in the related fields, and the epigallocatechin gallate belongsto a natural extract and can more safely play roles in various aspects clinically.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of epigallocatechin gallate. Background technique [0002] Pruritus is an unpleasant sensation that occurs on the skin and mucous membranes and causes the desire to scratch. It is the main symptom or manifestation of many skin diseases, certain systemic diseases, nerve damage, and mental diseases. Itching can be caused by exogenous factors (such as mechanical, electrical, etc.) , heat, cold and chemical stimulation, etc.) or endogenous factors (such as a variety of diseases, etc.); inflammation, allergy, degeneration, malignant tumors, psychological abnormalities and many other pathological processes can cause itching. [0003] Prolonged itching is often a pathological feature that seriously affects a person's quality of life. When pruritus occurs, people will unconsciously scratch out of their instinctive reaction, because scratching can temporarily relieve pru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P17/04A61P17/06
CPCA61K31/353A61K36/82
Inventor 陈丽华刘通冯雨郭然苏存锦黄娅
Owner SUZHOU UNIV
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