Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of osteocalcin in preparing medicine for treating Parkinson's disease

A technology for Parkinson's disease and osteocalcin, applied in drug combinations, pharmaceutical formulations, nervous system diseases, etc., can solve symptom fluctuations and dyskinesias, affect the physical and mental health and quality of life of the elderly, and cause heavy burdens on families and society, etc. question

Active Publication Date: 2021-08-03
SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both seriously affect the physical and mental health and quality of life of the elderly, and bring heavy burdens to families and society
The existing therapeutic drugs can only improve some motor symptoms of PD to a certain extent, but cannot reverse the neurodegenerative process, and long-term use can lead to complications such as symptom fluctuations and dyskinesias

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of osteocalcin in preparing medicine for treating Parkinson's disease
  • Application of osteocalcin in preparing medicine for treating Parkinson's disease
  • Application of osteocalcin in preparing medicine for treating Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] This embodiment relates to the use of osteocalcin to prepare a medicine for treating Parkinson's disease. The specific mechanism research test is as follows:

[0022] Rats used: 250-290g male, healthy and clean SD rats, purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0023] SD rat feeding conditions: ambient temperature 22±0.5 degrees, 12 hours / 12 hours light and dark alternately.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the use of osteocalcin to prepare Parkinson's disease treatment drug; the invention finds that exogenous administration of osteocalcin can improve the motor dysfunction of the Parkinson's disease rat model and alleviate its nigrostriatum Loss of dopaminergic neurons can alleviate PC12 cell apoptosis caused by 6‑OHDA through the AKT / GSK pathway in vitro. Therefore, osteocalcin, as a small molecule polypeptide hormone that can pass through the blood-brain barrier, can become a new drug for preventing and treating Parkinson's disease.

Description

technical field [0001] The invention belongs to the field of medical preparation, and in particular relates to the use of osteocalcin to prepare a drug for treating Parkinson's disease. Background technique [0002] The aging process of the body is usually accompanied by different degrees of bone density decline and neurodegeneration. Osteoporosis and Parkinson's disease (Parkinson's Disease, PD) are common elderly comorbid diseases, and clinical studies have shown that PD is an important factor that increases the risk of fracture. Osteoporosis results from a disruption of the balance between osteogenic formation and osteoclastic resorption, leading to structural destruction of bone, increased fragility, and increased risk of fracture; while Parkinson's disease is the most common neurodegenerative movement disorder, affecting about 1% of For people over 60 years old, the disease is related to the significant loss of dopaminergic neurons in the substantia nigra compacta, man...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P25/16
CPCA61K38/1709
Inventor 刘建民郭兴志李胜天单畅赵红燕孙立昊陶蓓
Owner SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com