Germinated fermented bean extract containing coumestrol and composition comprising same

A coumestrol and composition technology, applied in the field of germinated fermented bean extract and the composition containing it, can solve the problems of use method, dosage, safety and no results, etc., and achieve the effect of relieving menopausal symptoms

Active Publication Date: 2022-05-10
HUBIO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hormone replacement therapy (estrogen replacement therapy, estrogen replacement therapy) has been proposed as a preventive measure, but there are no results regarding the method of use, dosage, safety, etc.

Method used

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  • Germinated fermented bean extract containing coumestrol and composition comprising same
  • Germinated fermented bean extract containing coumestrol and composition comprising same
  • Germinated fermented bean extract containing coumestrol and composition comprising same

Examples

Experimental program
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Embodiment 1

[0046] [Example 1] Materials and methods

[0047] 1.1. Experimental materials

[0048] The germinated fermented beans used in this experiment were obtained from Hubio Co., Ltd. Soybeans obtained from Jeju Agricultural Research and Extension Services were germinated according to previous research and inoculated with Aspergillus oryzae for fermentation. After water washing, beneficiation and extraction using ultrasonic waves, it is dried and used as a test sample.

[0049] 1.2. Sample preparation

[0050] Soybeans are washed, selected, germinated, fermented with Aspergillus oryzae, filtered and then dried at 60°C. To 10 g of the dry sample, 80% ethanol was added at 7 mL / g to decompose it, and then hot water extraction was performed using ultrasonic waves. Thereafter, the germinated fermented bean extract was obtained by centrifugation, filtered through a polytetrafluoroethylene membrane (PTFE membrane), and then dried to obtain a sample. The above samples were dissolved in ...

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Abstract

The present invention relates to a germinated and fermented bean extract containing coumestrol, a preparation method thereof, and a composition comprising the germinated and fermented bean extract. For liver toxicity, the germinated and fermented bean extract of the present invention effectively protects the liver through the in vitro (in vitro) antioxidant activity and cell survival rate and blood tests of animal models, measurement of MDA, GST, GSH, SOD, CAT, etc. cell. In addition, it significantly increases bone density by increasing bone mineral content and has the effect of increasing the thickness and amount of cancellous bone. In addition, it also has the effect of relieving menopausal symptoms.

Description

technical field [0001] The present invention relates to a germinated and fermented bean extract containing coumestrol and a composition containing the same, which has the effect of protecting liver cells and increasing the bone density. In more detail, using the germinated and fermented bean extract of the present invention as a component in natural foods that has the effect of improving lipids in the body and menopausal disorders, hepatotoxicity that occurs during menopausal disorders was investigated by in vitro (invitro) antioxidant activity and cell survival. rate and animal models of blood tests, measurement of MDA (malone dialdehyde), GST (glutathione s-transferase, glutathione S-transferase), GSH (reduced glutathione), SOD (super Oxide dismutase, Superoxide dismutase), catalase (Catalase), etc. to verify the effect of protecting liver cells. In addition, in the present invention, the germinated and fermented bean extract of the present invention was used as a sample, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K36/48A23L33/105A61K31/35A61K31/34A61K9/08A61K9/20A61K9/48
CPCA61K36/48A61K31/352A61P15/12A61P19/10A61P1/16A61P3/04A23L33/105A61K2236/19A23V2002/00A23V2200/30A23V2200/31A23V2200/32A23V2200/306A23V2250/21A61K9/08A61K9/20A61K9/48A61K31/34A61K31/35
Inventor 李东成
Owner HUBIO
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