A kind of traditional Chinese medicine composition and its preparation method and application

A composition, the technology of Alzheimer's disease, applied in the field of medicine, can solve the problems such as the disease has not been seen, achieve no significant side effects, significant neuroprotection and immune regulation benefits, inhibition of apoptosis and proliferation of microglial cells Effect

Active Publication Date: 2021-02-26
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, at present, clinically, the basic pathogenesis of turbid toxin and blood stasis type Alzheimer's disease is mainly based on turbid toxin, phlegm and blood stasis, and then blinded brain orifice, but there is no relevant Chinese medicine research on this disease

Method used

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  • A kind of traditional Chinese medicine composition and its preparation method and application
  • A kind of traditional Chinese medicine composition and its preparation method and application
  • A kind of traditional Chinese medicine composition and its preparation method and application

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Effect test

Embodiment 1

[0074] A traditional Chinese medicine composition, in parts by mass, consists of the following Chinese medicines in parts by mass:

[0075] 16 parts of Coptis chinensis, 8 parts of Cortex Phellodendri, 16 parts of Gardenia, 15 parts of Salvia miltiorrhiza, 10 parts of turmeric, and 10 parts of Shichangpu.

[0076] A preparation method of a decoction comprising the above-mentioned Chinese medicine composition:

[0077] 1) Weigh 7 parts of the above-mentioned Chinese medicine composition, cut into pieces with scissors;

[0078] 2) Add 10 times the volume of double-distilled water to soak for 2 hours, cook in a medicine tank for 1 hour, start timing from slight boiling, and filter the medicine solution with 8 layers of gauze;

[0079] 3) Add 8 times the volume of single distilled water for the second time, boil for 1 hour in the same way, and filter with 8 layers of gauze;

[0080] 4) Pour out the medicine residue, squeeze it with gauze, combine the filtrate, and then wash the ...

Embodiment 2

[0086] A traditional Chinese medicine composition, in parts by mass, consists of the following Chinese medicines in parts by mass:

[0087] 15 parts of Coptis chinensis, 10 parts of Cortex Phellodendri, 15 parts of Gardenia, 15 parts of Salvia miltiorrhiza, 10 parts of turmeric, and 10 parts of Shichangpu.

[0088] The preparation method of decoction is as embodiment, the prescription of Chinese medicine is as embodiment 2.

[0089] 1. Model selection:

[0090] At present, there are many kinds of AD model animals, including Aβ oligomer intracerebral injection model, APP / PS1 double transgenic mouse model, etc. This application selects 5×FAD transgenic model mice for research, and 5×FAD mice carry 5 Familial gene mutation (transgenic mice with five familial Alzheimer's disease, 5×FAD), the mutations related to gene APP are K670N / M671L (Swedish), I716V (Florida) and V717I (London), and the mutations related to gene PS1 are M146L and L286V, the transgenic promoter is Thy1, and t...

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Abstract

The invention discloses a traditional Chinese medicine composition, a preparation method and application thereof. The traditional Chinese medicine composition is composed of Coptidis Rhizoma Cortex Phellodendron, Cortex Phellodendri, Gardenia, Salvia Miltiorrhiza, Curcuma longa and Shichangpu. The traditional Chinese medicine composition can significantly improve the learning and memory dysfunction of 5×FAD transgenic mice, reduce the expression of Aβ40 / 42 in the hippocampus, and increase the 5 The expression levels of pre- and post-synaptic proteins in the hippocampus of ×FAD transgenic mice can improve the excitatory synaptic transmission disorder in the hippocampus of 5×FAD mice, and at the same time inhibit the apoptosis of hippocampal neurons and the proliferation of microglia in 5×FAD mice In addition, it can inhibit the expression of inflammatory factors in the serum and hippocampus of 5×FAD mice, which provides a reliable theoretical basis for the preparation of drugs for the treatment or adjuvant treatment of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a traditional Chinese medicine composition and its preparation method and application. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a progressive neurodegenerative disease and a major dementia disease. According to the epidemiological data of the 2016 "Global Alzheimer's Disease Report", by 2016, there were approximately 47 million people with AD worldwide, which will increase to 74.7 million by 2030, and more than 1 by 2050. 31.5 million people [1] . About 58% of AD patients live in developing countries, and it is estimated that in 2050, AD patients in developing countries will exceed 68%, and 49% of new AD cases in 2015 appeared in Asia [1] . At present, China's population is in the stage of rapid aging development, and the incidence of AD is increasing year by year. At present, the number of AD patients ranks first in the world. Statisti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P25/28A61P25/00A61P37/02
CPCA61K9/0095A61K36/537A61K36/718A61K36/744A61K36/756A61K36/888A61K36/9066A61K2236/331A61K2236/39A61P25/00A61P25/28A61P37/02A61K2300/00
Inventor 张云龙刘妍
Owner GUANGZHOU MEDICAL UNIV
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