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Method for preparing Zaorenanshen oral liquid

A technology of jujube kernels for calming the nerves and frying wild jujube kernels, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and medical formulas, etc., can solve the problem of poor clarity of jujube kernels for soothing the nerves, affecting the therapeutic effect, and effective Problems such as ingredient loss, to achieve the effect of improving clarity, good treatment effect, and simple operation

Inactive Publication Date: 2018-10-02
LIAONING XIANCAOTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of this, the present invention discloses a preparation method of Zaoren Anshen Liquid to at least solve the problem that the Zaoren Anshen Liquid prepared by the previous method not only causes the loss of active ingredients, but also has the problem of the clarity of Zaoren Anshen Liquid. Poor, poor uniformity, affecting the treatment effect and other issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0032] Implementation case 1 (original process)

[0033] Stir-fried 250g of jujube kernels, 50g of Salvia miltiorrhiza, and 50g of Schisandra chinensis made from vinegar, add water to extract, the first time is 8 times the amount of water, and the extraction is 2 hours. The second time is 6 times the amount of water, and the extraction is 2 hours. Collect two extracts and concentrate under reduced pressure. After the concentrate is filtered, add refined honey and purified water to make the volume up to a density of 1.20-1.30g / cm 3 , which is obtained by potting.

[0034] The active ingredients were measured to be 0.068 mg / ml jujube saponin A, 0.167 mg / ml schisandrin, and 1.42 mg / ml salvianolic acid. But after a period of time, it becomes cloudy.

Embodiment example 2

[0036] Stir-fried 250g of jujube kernels, 50g of Salvia miltiorrhiza, and 50g of Schisandra chinensis made from vinegar, add water to extract, the first time is 8 times the amount of water, and the extraction is 2 hours. The second time is 6 times the amount of water, and the extraction is 2 hours. The two extracts were collected and concentrated under reduced pressure. The concentrate was poured into a refrigerated tank, and the supernatant was taken after refrigerating at 1°C for 12 hours, and subjected to tubular centrifugation at 16,000 r / min. The added concentration of the obtained centrifuged liquid is 1.36 to 1.38 g / cm 3 Refined honey and purified water to volume, so that the density is 1.20 ~ 1.30g / cm 3 . Heat to boil for 10 minutes and cool to room temperature. The external pressure ultrafiltration is adopted, and the ultrafiltration membrane with a molecular weight of 100,000 is passed through, and finally it is obtained by potting.

[0037] The measured active i...

Embodiment example 3

[0039] Stir-fried 250g of jujube kernels, 50g of Salvia miltiorrhiza, and 50g of Schisandra chinensis made from vinegar, add water to extract, the first time is 8 times the amount of water, and the extraction is 2 hours. The second time is 6 times the amount of water, and the extraction is 2 hours. The two extracts were collected and concentrated under reduced pressure. The concentrate was poured into a refrigerating tank, and the supernatant was taken after refrigerating at 1°C for 12 hours, and centrifuged. The obtained liquid after centrifugation is added with refined honey and purified water to make the density at 1.20~1.30g / cm 3 . Heat to boil for 10 minutes and cool to room temperature. The external pressure ultrafiltration is adopted, and the ultrafiltration membrane with a molecular weight of 500,000 is passed through, and finally it is obtained by potting.

[0040] The measured active ingredient content is 0.054 mg / ml jujube saponin A, 0.166 mg / ml schisandrin A, an...

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Abstract

The invention discloses a method for preparing a Zaorenanshen oral liquid. The method adopts a form of combining a plurality of separation modes, improves the clarity on the basis of realizing the maximum reservation of effective components in a Zaorenanshen liquid in the manners of cold sink and centrifugation of extracted concentrate, and external pressure ultrafiltration after the addition of oral liquid ingredients, and the like, realizes continuous alcohol-free production of the Zaorenanshen liquid, avoids the introduction of impurities, and has the advantages of simple operation, low cost and the like, and the Zaorenanshen liquid prepared by the method reserves effective components, and has good clarity, high uniformity and good treatment effect without introducing any impurities.

Description

technical field [0001] The invention discloses and relates to the technical field of preparation of traditional Chinese medicine oral liquid, in particular to a preparation method of Zaoren Anshen Liquid. Background technique [0002] Zaoren Anshen Liquid has the functions of nourishing the heart and nourishing the liver, soothing the mind and nourishing the mind. Among them, clarity is an important quality control index for traditional Chinese medicine oral liquid, which reflects product stability and is a key issue in the preparation process of oral liquid. Oral liquids with good clarity are generally of good quality. Therefore, how to improve the clarity has become a problem that must be paid attention to in the production of traditional Chinese medicine oral liquids. [0003] The main components of Zaoren Anshen Liquid are fried sour jujube seeds, Salvia miltiorrhiza and Schisandra chinensis made from vinegar, etc. The clarity of the oral liquid will be affected due to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/725A61K9/08A61K47/46A61P25/20
CPCA61K9/0095A61K36/537A61K36/57A61K36/725A61K36/79A61K47/46A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P25/20A61K2300/00
Inventor 王安宁
Owner LIAONING XIANCAOTANG PHARMA
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