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A kind of cefquinome powder injection

A technology for cefquinoxime and powder injection, which can be used in the field of powder injection and can solve the problems of unstable crystal form, decreased water solubility and the like

Active Publication Date: 2020-10-23
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem of water-solubility decline caused by the unstable crystal form of the cefquinome crystal form powder injection based on the Chinese patent document CN 105646543A during storage, the technical solution adopted in the present invention is:

Method used

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  • A kind of cefquinome powder injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Recipe: crystalline cefquinoxime: 10 g; polyethylene glycol 4000: 5 g; N-acyl sarcosine: 0.5 g.

[0021] Production process: (1) Melting: Heating polyethylene glycol 4000 to 55 degrees to melt, adding crystalline cefquinoxime and amino acid surfactant, mixing and stirring for 15 minutes. Obtain liquid A.

[0022] (2) Cooling: rapidly cool liquid A to below 15 degrees to obtain solid mixture B.

[0023] (3) Pulverization: The solid mixture B is ultrafinely pulverized.

[0024] (4) Mixing: The pulverized substances were mixed for 30 minutes.

[0025] (5) Sub-packaging: It is enough to sub-pack in a sterile room, and the sub-packaging specification is 1g / piece (calculated by cefquinoxime).

Embodiment 2

[0027] Prescription: crystalline cefquinoxime: 10g; polyethylene glycol 4000: 10g; N-acyl sarcosine: 0.8g

[0028] Production process: (1) Melting: Heating polyethylene glycol 4000 to 55 degrees to melt, adding crystalline cefquinoxime and amino acid surfactant, mixing and stirring for 15 minutes. Obtain liquid A.

[0029] (2) Cooling: rapidly cool liquid A to below 15 degrees to obtain solid mixture B.

[0030] (3) Pulverization: The solid mixture B was mechanically pulverized.

[0031] (4) Mixing: The pulverized substances were mixed for 15 minutes.

[0032] (5) Sub-packaging: It is enough to sub-pack in a sterile room, and the sub-packaging specification is 1g / piece (calculated by cefquinoxime).

Embodiment 3

[0034] Formulation: crystalline cefquinoxime: 10g; polyethylene glycol 4000: 10g; N-acyl sarcosine: 1.2g

[0035] Production process: (1) Melting: Heating polyethylene glycol 4000 to 55 degrees to melt, adding crystalline cefquinoxime and amino acid surfactant, mixing and stirring for 15 minutes. Obtain liquid A.

[0036] (2) Cooling: rapidly cool liquid A to below 15 degrees to obtain solid mixture B.

[0037] (3) Pulverization: The solid mixture B was mechanically pulverized.

[0038] (4) Mixing: The pulverized substances were mixed for 15 minutes.

[0039] (5) Sub-packaging: It is enough to sub-pack in a sterile room, and the sub-packaging specification is 1g / piece (calculated by cefquinoxime).

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Abstract

Cefquinome powder injection is characterized by comprising crystalline cefquinome, and polyethylene glycol and amino acid surfactant acting as crystal transition inhibitory auxiliaries; the mass ratioof the polyethylene glycol to the amino acid surfactant is 10:(0.5-2). A preparation method of the cefquinome powder injection includes the steps of (1) melting, to be specific, heating the polyethylene glycol to 50-65 DEG C for melting, adding the crystalline cefquinome and the amino acid surfactant, and mixing to obtain melt A; (2) cooling, to be specific, quickly cooling the melt A to solid state to obtain solid mixture B; (3) crushing the solid mixture B.

Description

technical field [0001] The present invention relates to a powder injection for containing cefquinoxime. Background technique [0002] Cefquinome (Cefquinome CAS::84957-30-2) is a fourth-generation animal-specific cephalosporin antibiotic developed and developed by Hearst Animal Health Company in Germany in the 1980s. It was first approved for marketing in 1993. Cefquinoxime has broad-spectrum antibacterial activity and strong antibacterial activity. It is mainly used in the clinical treatment of swine and bovine respiratory system infections caused by sensitive bacteria, mastitis in dairy cows and agalactia syndrome in sows. At present, the raw materials used in the commercially available cefquinome preparations are cefquinome sulfate - cefquinome sulfate (Cefquinome Sulfate, CAS: 118443-89-3). The raw material properties of cefquinome sulfate are white, off-white or Light yellow crystalline powder, slightly soluble in water, insoluble in ethanol, melting point 179.9℃. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/10A61K47/18A61K31/546A61P31/04
CPCA61K9/145A61K9/146A61K31/546A61P31/04
Inventor 聂丽娜夏雪林刘爱玲李旭东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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