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Systems and methods for conducting electrochemical impedance spectroscopy

An electrochemical and impedance measurement technology, applied in the field of living cell biosensing, can solve problems such as affecting the quality of data interpretation, and achieve the effect of improving data quality, accurate measurement results, and improving measurement results

Active Publication Date: 2018-10-23
VRIJE UNIV BRUSSEL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This can significantly affect the interpretation of the data as well as the quality of the results in a negative way, and must therefore be avoided

Method used

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  • Systems and methods for conducting electrochemical impedance spectroscopy
  • Systems and methods for conducting electrochemical impedance spectroscopy
  • Systems and methods for conducting electrochemical impedance spectroscopy

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Embodiment Construction

[0108] The present invention will be described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. The drawings described are merely schematic and non-limiting. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. The dimensions and relative dimensions do not correspond to actual reductions for the practice of the invention.

[0109] Furthermore, the terms "first", "second", etc. in the description and claims are used to distinguish between similar elements and not necessarily to describe an order, whether temporally, spatially, sequentially, or sequentially. any other way. It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operation in other sequences than described or illustrated herein.

[0110] Al...

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Abstract

A system for measuring electrical characteristics of bioparticles is described. The system comprises an incubator for performing electrochemical measurements in a defined environment and a substrate holder positioned in said incubator for holding a substrate comprising a plurality of wells (110). The system is furthermore configured for continuously or regularly measuring electrochemical data. Thesystem also comprises a processing means for comparing the continuously or regularly measured electrochemical data with reference data and for determining a moment for adding an active compound basedon said comparison.

Description

field of invention [0001] The invention relates to the field of living cell biosensing. More specifically, the present invention relates to methods and systems for performing electrochemical impedance spectroscopy (EIS) on living cells in wells. Background technique [0002] The electrochemical impedance spectroscopy (EIS) method is used to study cell cultures in a non-invasive manner. For this purpose, usually cell cultures are grown in wells with 2 electrodes on the bottom surface. The method generally involves adding the active compound to the cell culture in these wells after an initial period of cell growth. From that moment on, the evolution of the response is followed in order to understand the effect of the active compound on the cells in the well. This in turn will provide information on the working mechanism of the active compound. [0003] Cell cultures grown in wells will exhibit specific growth paths that are maximized when the entire bottom is densely packe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/02B01L3/00G01N33/483
CPCB01L3/5085G01N33/4836B01L1/025B01L2200/143B01L2300/0645B01L2300/0829B01L2300/0851G01N27/026C12M41/46
Inventor 伊夫·万英格尔格姆巴特·兰代特斯文·凡高斯
Owner VRIJE UNIV BRUSSEL