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Application of magnesium alloy in preparation of degradable biliary stent

A magnesium alloy and biliary tract technology, applied in the field of medical materials, can solve the problems of exacerbation of chronic pancreatitis and blockage of stents, and achieve the effects of avoiding complications, reducing blockage, and being easy to install

Inactive Publication Date: 2018-11-13
王缨 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the biggest obstacle limiting the application of CSEMS is stent migration, and its complications are cholangitis, stent blockage, and exacerbation of chronic pancreatitis caused by stent migration

Method used

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  • Application of magnesium alloy in preparation of degradable biliary stent
  • Application of magnesium alloy in preparation of degradable biliary stent
  • Application of magnesium alloy in preparation of degradable biliary stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Preparation of degradable magnesium alloy scaffold

[0058] Using the magnesium alloy WE43 with a mass of 0.02g, the prepared magnesium alloy microtubes were processed into such as figure 1 The shown magnesium alloy biliary stent has a wall thickness of 0.15 mm and a length of 25 mm. The bracket includes: a number of "Z" support rod rings distributed in the radial direction; a number of "S" link rods distributed in the axial direction, and the "S" type link rods are connected continuously, that is, "head to head" connects each adjacent The support rods form a network structure.

[0059] After polishing, the stent is crimped onto a balloon catheter and packaged for sterilization. A balloon catheter with a stent (stent delivery system) can enter the body along the guide wire, and then the magnesium alloy biliary stent is expanded to 4.0mm (outer diameter) by balloon inflation.

[0060] 2. Experimental reagents and main instruments

[0061] Experimental reagent used...

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Abstract

The invention relates to the technical field of medical materials and provides a degradable biliary stent. The degradable biliary stent is a magnesium alloy degradable biliary stent. The magnesium alloy degradable biliary stent comprises a plurality of ring-shaped supporting parts distributed in the radial direction and used for radial supporting during ball expansion and a plurality of connectingparts distributed in the axial direction and used for axial connection with the adjacent ring-shaped supporting parts to form a net-like structure. The magnesium alloy degradable biliary stent replaces a non-degradable biliary stent, serves as a ball expansion stent to be implanted at the narrow part of biliary lesion and plays a drainage effect in a support, and the phenomenon can be avoided that the limitations of a stent tube cause complications or the non-degradable biliary stent is difficult to take out. Different from a covered stent, the stent is difficult to displace and has a wider lesion position application range. It is proved through animal experiments that the biliary tracts at the suture parts of experimented animals in an experimental group are smooth and free of biliary sludge or lithogenesis by applying the magnesium alloy degradable biliary stent, and the stent is completely degraded in the eighth week.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to the application of a magnesium alloy in the preparation of a degradable biliary stent, that is, to a degradable biliary stent, and in particular to a magnesium alloy biliary stent for the biliary system. Background technique [0002] The biliary system mainly includes the gallbladder, common hepatic duct, and common bile duct. It has the functions of secreting, storing, concentrating, and transporting bile, and plays an important role in regulating the discharge of bile into the duodenum. The bile duct transports bile to the gallbladder and duodenum, and the capillary bile duct plays an important role in regulating the flow and composition of bile; the gallbladder has the functions of concentrating, storing, discharging and secreting bile. And bile has the following main physiological functions: (1) emulsifying fat: after bile salt enters the intestinal tract, it combin...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/02A61F2/91
CPCA61F2/91A61F2210/0004A61L31/022A61L31/148
Inventor 王缨王剑明程焰万江
Owner 王缨
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