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Application of composite amino acid in preparing medicine for treating oligoasthenozoospermia

A compound amino acid, asthenozoospermia technology, which is applied in the application field of medicine to achieve the effects of improving performance, inhibiting apoptosis of spermatogenic cells, and increasing the level of energy metabolism

Inactive Publication Date: 2018-11-16
商学军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, there is no report on the application of compound amino acids in the treatment of oligoasthenospermia

Method used

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  • Application of composite amino acid in preparing medicine for treating oligoasthenozoospermia
  • Application of composite amino acid in preparing medicine for treating oligoasthenozoospermia
  • Application of composite amino acid in preparing medicine for treating oligoasthenozoospermia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Protective Effect of Compound Amino Acids on Testis and Epididymis Damage in Rats with Oligopharyngeal Asthenozoospermia Induced by Tripterygium Glycoside

[0028] 1 Materials and methods

[0029] 1.1 Materials

[0030] 1.1.1 Experimental animals 40 SPF-grade healthy male SD rats, weighing 200-250 g, were provided by the Department of Comparative Medicine, Nanjing General Hospital. The experimental animals were kept in the Department of Comparative Medicine, Nanjing General Hospital. The experiment started after one week of adaptive feeding. The rats were free to eat and drink, and the drinking water was changed every day, and the bedding in the cage was changed every other day to keep it clean and dry. The daily light time is 12h.

[0031] 1.1.2 Drugs and main reagents GTW were purchased from Shanghai Fudan Fuhua Pharmaceutical Co., Ltd. (Guoyao Zhunzi Z31020415, batch number: 160303, specification: 10mg / tablet), and the raw material powder of compound amin...

Embodiment 2

[0059] Example 2 Protective effect of compound amino acid on testis and epididymis damage in rats with oligoasthenozoospermia induced by tripterygium glycosides

[0060]Clinically, the reproductive hormone levels of infertile patients are often detected as an important reference for the treatment of infertility. The most commonly used ones include testosterone (T), luteinizing hormone (LH), follicle stimulating hormone ( follicle stimulating hormone, FSH) and inhibin B (inhibin B, INHB). In this example, these four hormones were tested to explore the protective effect of compound amino acids on the hypothalamus-pituitary-testicular gonad axis in rats with oligoasthenospermia induced by tripterygium glycosides (multiglycosides of Tripterygium wilfordii Hook.f., GTW).

[0061] 1 Materials and methods

[0062] 1.1 Materials

[0063] 1.1.1 Experimental animals 40 SPF-grade healthy male SD rats, weighing 220-250 g, were provided by the Department of Comparative Medicine, Nanjing ...

Embodiment 3

[0088] Example 3 Protective Effect of Compound Amino Acids on Energy Metabolism of Reproductive System of Rats with Oligospermia and Asthenozoospermia Induced by Tripterygium wilfordii Polyglycosides

[0089] Amino acids are the components of protein, one of the three major energy-supplying substances. Among them, essential amino acids can only be ingested from food and cannot be synthesized by themselves. Amino acids synthesize enzymes necessary for energy metabolism, and indirectly participate in energy metabolism through three major material cycles. This example studies the energy metabolism of the reproductive system of rats with oligoasthenospermia caused by tripterygium wilfordii with compound amino acids. To explore the improving effect of compound amino acids on energy metabolism.

[0090] 1 Materials and methods

[0091] 1.1 Materials

[0092] 1.1.1 Experimental animals 40 SPF-grade healthy male SD rats, weighing 220-250 g, were provided by the Department of Compara...

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Abstract

The invention discloses application of composite amino acid in preparing a medicine for treating oligoasthenozoospermia. The composite amino acid comprises the following main medicine components: leucine, isoleucine, lysine hydrochloride, phenylalanine, threonine and the like. Test results show that (1) the composite amino acid has a remarkable protection function on dyszoospermia caused by GTW (Multiglycosides of Tripterygium wilfordii Hook.f.), oligoasthenozoospermia caused by GTW can be alleviated, morphological changes of testis and epididymis can be reduced, and spermatogenic cell apoptosis can be inhibited; (2) testis functions of rats suffering from oligoasthenozoospermia caused by GTW can be remarkably improved, a normal reproduction hormone level can be maintained, and normal functions of hypothalamus-hypophysis-testis gonad axes can be protected; (3) an energy metabolism level of a reproductive system of a rat suffering from oligoasthenozoospermia caused by GTW can be remarkably increased, energy metabolism of sperms can be improved, and sperm quality can be improved; (4) antioxidation levels of testis and epididymis can be increased, and sperm quality can be improved; the composite amino acid can be used as an active component to prepare medicines for treating oligoasthenozoospermia.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of compound amino acids in the preparation of medicines for treating oligoasthenospermia. Background technique [0002] At present, about 15% of couples of childbearing age in the world cannot conceive within one year of marriage and need interventional treatment, of which male factors account for about 50%. The semen examination of infertile men mainly shows oligospermia, asthenospermia or oligoasthenospermia. In the process of diagnosis and treatment, most patients cannot find a clear cause, so it is also called idiopathic oligospermia, idiopathic asthenospermia, and idiopathic oligoasthenospermia. For these patients, there is still no special effect medicine. Tripterygium wilfordii Hook.f. (multiglycosides of Tripterygium wilfordii Hook.f., GTW), also known as Tripterygium wilfordii Hook.f., is a fat-soluble mixed component extracted from the root of the Eu...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61K31/198A61K31/196A61K31/07A61K31/592A61K31/51A61K31/525A61K31/455A61K31/4415A61K31/519A61K31/197A61K31/714A61K31/375A61K31/355A61P15/08
CPCA61K31/405A61K31/07A61K31/196A61K31/197A61K31/198A61K31/355A61K31/375A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/592A61K31/714A61P15/08A61K2300/00
Inventor 商学军王阳贇张国巍王可佳王仲蓀
Owner 商学军
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