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Bionic mineralized repairing desensitizer

A biomimetic mineralization and desensitizing agent technology, used in dental preparations, medical science, dentistry, etc., can solve the problem of insufficiency of desensitizing agents, and achieve long-term treatment of dentin hypersensitivity and prolong the effect of action time.

Inactive Publication Date: 2018-11-23
成都爱睿康乐医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the fact that existing desensitizers on the market cannot meet the ideal long-acting anti-dentine hypersensitivity treatment needs, the present invention provides a desensitizing agent with deep and long-term repairing effect based on a biomimetic mineralization mechanism

Method used

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  • Bionic mineralized repairing desensitizer
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  • Bionic mineralized repairing desensitizer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This example relates to the feasible formula and preparation process of the biomimetic mineralization restoration desensitization agent:

[0023] Dendrimer 1000ppm

[0024] Bioactive Glass 25%

[0025] Tripotassium Phosphate 10%

[0026] Glycerin 2%

[0027] Polyethylene glycol 51%

[0028] Xanthan Gum 3%

[0029] Titanium Dioxide 5%

[0030] Fragrance 0.5%

[0031] Sodium Saccharin 1%

[0032] Ethylparaben 0.5%,

[0033] Lauryl Sulfate 2%

[0034] The preparation process mainly includes the following steps:

[0035] (1) prepare liquid A by mixing tripotassium phosphate and dendrimer;

[0036] (2) Glycerin, polyethylene glycol, xanthan gum, titanium dioxide, essence, sodium saccharin, ethyl paraben, lauryl sulfate, and bioactive glass are prepared into liquid B;

[0037] (3) After mixing liquid A and liquid B evenly, they are dispensed into preparation bottles to obtain a biomimetic mineralization repairing desensitization agent.

Embodiment 2

[0039] The present embodiment relates to the specific use method of the biomimetic mineralization restoration desensitization agent, wherein the medical device is an example of a thermoplastic dental tray, and the specific steps are as follows:

[0040] (1) The desensitizer and a certain amount of water are stirred to obtain a thick white paste;

[0041] (2) Spread all the biomimetic mineralization restoration desensitization agent evenly in the thermoplastic dental tray, place it in the mouth of the subject, and ensure that the sensitive part of the tooth is coated with the desensitization agent, and let the subject occlude for at least 5 minutes (if If discomfort occurs during use, such as retching, excessive saliva, etc., you can take out the tray for a while and wait for relief before putting it back in).

[0042] (4) After the occlusal, the subject rinses his mouth to remove the residue in the mouth, and the subject is required not to brush his teeth, eat or drink within ...

Embodiment 3

[0044] This example relates to the experimental verification process of the sealing effect of the biomimetic mineralization restoration desensitization agent on dentin tubules in Example 1.

[0045] The dentin samples were etched and demineralized with ethylenediaminetetraacetic acid (EDTA), and the samples were sonicated in an ultrasonic cleaner for 30 min, put into 10 mL of 0.5 mol / L EDTA (pH=8.0) solution for 1 min, and taken out with PBS. Rinse the surface, sonicate again for 5 min and store in PBS solution at 4°C.

[0046] After the dentin sample was treated with deionized water or the biomimetic mineralization restoration desensitization agent in Example 1 for 30 min, rinsed three times in PBS solution, and then each treated dentin sample was placed in a PP centrifuge tube separately , Pour 5mL of simulated saliva, and store at a constant temperature of 37°C. The simulated saliva is replaced once a day. After 4 weeks, the mineralized dentin samples are taken out, washed ...

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Abstract

The invention provides a bionic mineralized repairing desensitizer and a using method thereof. The bionic mineralized repairing desensitizer is characterized by comprising 1-100000 ppm dendritic macromolecule, 1%-50% of bioactive glass, 0.1%-20% of tripotassium phosphate, 1%-5% of glycerinum, 30%-70% of polyethylene glycol, 0.5%-8% of xanthan gum, 1%-10% of titanium dioxide, 0.1%-1% of essence, 0.1%-2% of sodium saccharin, 0.1%-1% of ethylparaben, and 1%-8% of lauryl sulfate. The dendritic macromolecule comprises hydroxyl-terminated, carboxyl-terminated, phosphate radical-terminated or amino-terminated 0-5-generation polyamide-amine dendritic macromolecules; and the bioactive glass comprises (CaO)x(NaO2)y(SiO2)z(P2O5)1-x-y-z, wherein x is equal to 0.25-0.45, y is equal to 0-1, and z is equal to 0.34-0.64. The invention further provides a using method of the bionic mineralized repairing desensitizer. The bionic mineralized repairing desensitizer is scraped into a medical device capableof being matched with teeth to be uniformly distributed, and is bitten in a mouth for 1 min and longer, and the medical device comprises a foam denture, a thermoplastic denture and a teeth whitening strip and the like which are seen in the market; and the fact shows that the bionic mineralized repairing desensitizer can close exposed dentin deeply for a long time, so that long-acting desensitization is realized, and the dentin hypersensitivity is relieved.

Description

technical field [0001] The invention specifically relates to a biomimetic mineralization restoration desensitization agent for the treatment of dentin hypersensitivity and a method for using the desensitization agent Background technique [0002] Dentin hypersensitivity refers to short, sharp pains on exposed dentin in response to external stimuli that cannot be attributed to tooth defects or lesions caused by other specific causes. Typical stimuli include thermal stimuli, air blow stimuli, mechanical stimuli or chemical irritation. When the dentine is exposed and the dentinal tubules are open and unobstructed, external stimuli can cause the tubule fluid to flow, and the nerve fibers or nerve conduction media inside and outside the dentine cytoplasm feel this stimulus, and generate impulses to transmit, causing the sensation of pain. Based on the etiology and pathogenesis of this dentine sensitivity, a large number of clinical practices and researches have proved that reduc...

Claims

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Application Information

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IPC IPC(8): A61K6/00A61K6/02A61K6/027A61K6/087A61K6/097A61K6/891A61K6/898
CPCA61K6/20A61K6/80A61K6/836A61K6/891A61K6/898
Inventor 于通
Owner 成都爱睿康乐医疗器械有限公司
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