High molecular desensitisation paste and preparation method thereof
A polymer and sensitive paste technology, applied in the field of oral health care products, can solve the problems of unable to solve dental complications, slow desensitization effect, single effect, etc., to reduce the growth of oral bacteria, realize tooth sensitivity restoration, The effect of repairing tooth sensitivity
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experiment example 1
[0043] Experimental Example 1: Antibacterial Test
[0044] Harmful bacteria in the oral cavity act on the gums for a long time, eventually leading to gingivitis and periodontitis. Therefore, it inhibits the growth of harmful bacteria in the oral cavity and can alleviate oral diseases. In order to determine the antibacterial performance of the product of the present invention on harmful bacteria in the oral cavity, this experiment uses the main bacterium that causes gingivitis: Actinomycetin-attached Actinobacillus ATCC 29523 to test.
[0045] Sample preparation: inoculate the bacteria in the sterilized broth medium, cultivate overnight at 35°C, and prepare a bacterial suspension for use; dilute the original bacterial suspension (mother solution) to 10 6 cfu / ml was used as the bacterial solution for the experiment.
[0046] For Examples 1-5, Comparative Example 1 (Aominqing group) and Comparative Example 2 (Tianfu desensitizing paste group), take 100 mg of the paste, dilute i...
experiment example 2
[0048] Experimental Example 2: Stability Test
[0049] In order to verify the safety performance of the product of the present invention, the product of the present invention has been verified by a stability experiment.
[0050] The compositions prepared in each example were packaged according to the operating procedures, and the compositions were placed in a high temperature of 60°C, a low temperature of 5°C, and a normal temperature of 20°C, and the storage time was 0 day, 30 days, 60 days, and 90 days respectively. The performance indicators are shown in Table 3 below.
[0051] The stability test results of each embodiment of table 3 under different storage conditions
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[0055] From the results in Table 3, it can be seen that when stored at 5°C, 20°C, and 60°C for 3 months, the appearance of the compositions provided by Examples 1 to 5 are all free from delamination, odor, discoloration, and hardening It is pasty, and its pH value does n...
experiment example 3
[0056] Experimental example 3: Detection of desensitization effect
[0057] Take 90 complete teeth, remove the soft tissue and calculus remaining in the periodontal periodontal area, clean them ultrasonically, and store them in 0.1% thymol solution at 4°C. Use a low-speed cutting machine to cut the tooth body at 1.0mm above the enamel-cementum junction, perpendicular to the long axis of the tooth body, into a 1.0mm thick dentin disk, cut a piece from each tooth, mark the medullary surface, and the near-coronal surface as the treatment surface , placed in deionized water for ultrasonic cleaning for 10 min, and then stored in deionized water for later use. Divide 90 samples into 9 groups of A, B, C, D, E, F, G, H, I, 10 samples in each group. The 9 groups of samples were treated with 0.5 mol / L EDTA (pH 7.4) for 2 minutes to form a sensitive dentin model, and finally rinsed with water for 30 seconds.
[0058] Dip the polymer desensitizing paste products of Examples 1-5 of the p...
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