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High molecular desensitisation paste and preparation method thereof

A polymer and sensitive paste technology, applied in the field of oral health care products, can solve the problems of unable to solve dental complications, slow desensitization effect, single effect, etc., to reduce the growth of oral bacteria, realize tooth sensitivity restoration, The effect of repairing tooth sensitivity

Inactive Publication Date: 2020-02-07
四川艾医生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the desensitizing toothpaste or desensitizing paste that claims to have a certain desensitizing effect on teeth mainly uses a single strontium salt or potassium salt, such as strontium chloride, strontium nitrate, strontium acetate, potassium nitrate, etc., although it can It can desensitize to a certain extent, but it can only achieve rapid desensitization, but it cannot repair the teeth in the later stage or has limited restoration effect, and at the same time, it cannot solve some complications of tooth sensitivity, that is, "treating the symptoms but not the root cause". Easy to relapse
[0004] At the same time, the human oral cavity is a relatively complex internal environment, which contains a large number of harmful bacteria. Some patients with severe tooth sensitivity may already have complications such as oral ulcers, periodontal disease or gingivitis. At this time, simple desensitization and restoration Products can no longer solve complex oral problems, and oral antibacterial is needed to assist in the treatment of tooth sensitivity and its complications
[0005] The effects of some oral health care compositions disclosed in the prior art are relatively simple and the desensitization effect is slow, which cannot meet the complex oral environment.

Method used

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  • High molecular desensitisation paste and preparation method thereof
  • High molecular desensitisation paste and preparation method thereof
  • High molecular desensitisation paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0043] Experimental Example 1: Antibacterial Test

[0044] Harmful bacteria in the oral cavity act on the gums for a long time, eventually leading to gingivitis and periodontitis. Therefore, it inhibits the growth of harmful bacteria in the oral cavity and can alleviate oral diseases. In order to determine the antibacterial performance of the product of the present invention on harmful bacteria in the oral cavity, this experiment uses the main bacterium that causes gingivitis: Actinomycetin-attached Actinobacillus ATCC 29523 to test.

[0045] Sample preparation: inoculate the bacteria in the sterilized broth medium, cultivate overnight at 35°C, and prepare a bacterial suspension for use; dilute the original bacterial suspension (mother solution) to 10 6 cfu / ml was used as the bacterial solution for the experiment.

[0046] For Examples 1-5, Comparative Example 1 (Aominqing group) and Comparative Example 2 (Tianfu desensitizing paste group), take 100 mg of the paste, dilute i...

experiment example 2

[0048] Experimental Example 2: Stability Test

[0049] In order to verify the safety performance of the product of the present invention, the product of the present invention has been verified by a stability experiment.

[0050] The compositions prepared in each example were packaged according to the operating procedures, and the compositions were placed in a high temperature of 60°C, a low temperature of 5°C, and a normal temperature of 20°C, and the storage time was 0 day, 30 days, 60 days, and 90 days respectively. The performance indicators are shown in Table 3 below.

[0051] The stability test results of each embodiment of table 3 under different storage conditions

[0052]

[0053]

[0054]

[0055] From the results in Table 3, it can be seen that when stored at 5°C, 20°C, and 60°C for 3 months, the appearance of the compositions provided by Examples 1 to 5 are all free from delamination, odor, discoloration, and hardening It is pasty, and its pH value does n...

experiment example 3

[0056] Experimental example 3: Detection of desensitization effect

[0057] Take 90 complete teeth, remove the soft tissue and calculus remaining in the periodontal periodontal area, clean them ultrasonically, and store them in 0.1% thymol solution at 4°C. Use a low-speed cutting machine to cut the tooth body at 1.0mm above the enamel-cementum junction, perpendicular to the long axis of the tooth body, into a 1.0mm thick dentin disk, cut a piece from each tooth, mark the medullary surface, and the near-coronal surface as the treatment surface , placed in deionized water for ultrasonic cleaning for 10 min, and then stored in deionized water for later use. Divide 90 samples into 9 groups of A, B, C, D, E, F, G, H, I, 10 samples in each group. The 9 groups of samples were treated with 0.5 mol / L EDTA (pH 7.4) for 2 minutes to form a sensitive dentin model, and finally rinsed with water for 30 seconds.

[0058] Dip the polymer desensitizing paste products of Examples 1-5 of the p...

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Abstract

The invention discloses high molecular desensitisation paste and a preparation method thereof. The high molecular desensitisation paste comprises the components in percentage by mass of 40-65% of a hydrating agent, 10-40% of an abrasive, 1-2% of a foaming agent, 0.5-2.5% of chitosan quaternary ammonium salt, 6-15% of strontium chloride, 2-12% of bioactive glass, 0.4-1% of a thickening agent, 0.5-1% of essence and 1-2% of a sweetening agent. The preparation method comprises the steps of adding the thickening agent and the chitosan quaternary ammonium salt in the hydrating agent, performing uniform stirring to obtain mixed liquid, subsequently, adding the strontium chloride and the foaming agent, performing uniform stirring, adding the bioactive glass, performing uniform stirring and dispersing, adding the abrasive, continuing to perform stirring to obtain uniform paste, finally, adding the essence and the sweetening agent, and performing uniform stirring to obtain pastry gelata form orpaste form high molecular desensitisation paste. The high molecular desensitisation paste not only can realize quick desensitisation, but also can reduce breeding of oral bacteria, and can realize repair of sensitivity of teeth within a certain time.

Description

technical field [0001] The invention belongs to the technical field of oral health care products, and more specifically relates to a polymer desensitization paste capable of effective desensitization, sterilization and tooth restoration and a preparation method thereof. Background technique [0002] Tooth sensitivity means that when the teeth are stimulated by cold, heat, sour, sweet and mechanical action (rubbing, biting hard objects), there will be a sudden and sharp soreness feeling, and when the stimulus is removed, the soreness will disappear immediately . At present, there are three main theories for its pathogenesis: "neural theory", "conduction theory" and "hydrodynamic theory". Among them, the "hydrodynamic theory" can better explain most clinical phenomena, and thus is widely accepted. The theory holds that there is dentine fluid in the dentine tubules, and when there is an external stimulus, the flow rate of the dentine fluid will change, causing the expansion a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/20A61K8/25A61Q11/00A61Q17/00
CPCA61K8/736A61K8/20A61K8/25A61Q11/00A61Q17/005A61K2800/412
Inventor 黄敏唐迎波
Owner 四川艾医生医疗科技有限公司
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