Preparation method and application of surfactant containing octacosanol

A technology of octadecanol and surfactant, applied in the field of bioengineering, can solve the problems of poor water solubility of higher fatty alcohols, affect flavor and sensory perception, etc., and achieve the effects of significant effect, enhanced endurance, and enhanced athletic ability.

Inactive Publication Date: 2018-11-23
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the poor water solubility of higher fatty alcohols, adding them to beverages, cosmetics, and foods will affect their flavor and sensory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Add polyglutamic acid with a molecular weight of 750,000 to water at a concentration of 0.1g / L and Tween 80 at a concentration of 0.2g / L, and stir at a high speed of 9000r / min to prepare a polyglutamic acid solution;

[0022] 2) Add octacosanol at a concentration of 0.2 g / L to the polyglutamic acid solution prepared in step 1), add lipase at a concentration of 5000 U / ml, stir and react at 37°C for 8 hours to obtain polyglutamic acid Octacosyl Ester Emulsion;

[0023] 3) Spray-dry the poly-glutamic acid octacosyl ester emulsion, the spray-drying parameters: the inlet temperature is 250°C, the air flow rate is 120kg dry air / h, and the emulsion flow rate is 2kg / h to obtain polyglutamic acid Octacosyl Ester Powder.

Embodiment 2

[0025] 1) Add polyglutamic acid with a molecular weight of 700,000 to water at a concentration of 0.1 g / L and Tween 80 at a concentration of 0.2 g / L, and stir at a high speed of 8000 r / min to prepare a polyglutamic acid solution;

[0026] 2) Add octacosanol at a concentration of 0.1 g / L to the polyglutamic acid solution prepared in step 1), add lipase at a concentration of 1000 U / ml, stir and react at 30°C for 4 hours to obtain polyglutamic acid Octacosyl Ester Emulsion;

[0027] 3) Spray-dry the poly-glutamic acid octacosyl ester emulsion, the spray-drying parameters: the inlet temperature is 200°C, the air flow rate is 100kg dry air / h, and the emulsion flow rate is 2kg / h to obtain polyglutamic acid Octacosyl Ester Powder.

Embodiment 3

[0029] 1) Add polyglutamic acid with a molecular weight of 800,000 to water at a concentration of 0.2 g / L and Tween 80 at a concentration of 0.5 g / L, and stir at a high speed of 10000 r / min to prepare a polyglutamic acid solution;

[0030] 2) Add octacosanol at a concentration of 0.5 g / L to the polyglutamic acid solution prepared in step 1), add lipase at a concentration of 5000 U / ml, stir and react at 40°C for 8 hours to obtain polyglutamic acid Octacosyl Ester Emulsion;

[0031] 3) Spray-dry the poly-glutamic acid octacosyl ester emulsion, the spray-drying parameters: the inlet temperature is 250°C, the air flow rate is 120kg dry air / h, and the emulsion flow rate is 3kg / h to obtain polyglutamic acid Octacosyl Ester Powder.

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Abstract

The invention discloses a preparation method and application of a surfactant containing octacosanol. According to the preparation method, octacosanol is added into a polyglutamic acid aqueous solution, catalytic synthesis is carried out through lipase so as to obtain a polyglutamic acid octacosanol ester emulsion, and spray drying is carried out so as to obtain polyglutamic acid octacosanol esterpowder. The preparation method has the advantages that the polymer surfactant of polyglutamic acid octacosanol ester is synthesized and prepared by utilizing octacosanol and polyglutamic acid, so thatthe problems that higher aliphatic alcohol is poor in water solubility, and no flavor and sense are generated when the surfactant is added in food, cosmetics and beverages can be solved, and the uniformity is good; and meanwhile, polyglutamic acid and octacosanol have complementary and synergistic effects on body regulation, so that the exercise ability of old people can be greatly improved.

Description

technical field [0001] The invention relates to a preparation method and application of a surfactant containing octacosanol, belonging to the field of bioengineering. Background technique [0002] Octacosanol is a biologically active substance. Its main physiological effects include: 1) Improve endurance, energy and physical strength; 2) Shorten muscle nerve reaction time and improve response sensitivity; 3) Promote hormone function and relieve muscle pain; 4) Improve myocardial function and reduce systolic blood pressure; 5) Improve the body's basal metabolic rate. Octacosanol can be used to treat osteoporosis with hypercalcemia, treat hypercholesterolemia and hyperlipoproteinemia diseases, and stimulate the sexual behavior of animals and humans. Cosmetics containing octacosanol can promote skin blood circulation and Activate cells, have anti-inflammatory, prevent and treat skin diseases and other effects. Moreover, octacosanol is extremely safe and is used in a small amo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/88A61K8/86A61Q19/00A23L2/52A23L33/10
CPCA23L2/52A23V2002/00A61K8/342A61K8/86A61K8/88A61K2800/596A61Q19/00A23L33/10A23V2200/30A23V2300/10
Inventor 汤佳鹏葛彦朱俐
Owner NANTONG UNIVERSITY
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