Use of cyperene-2,5,8-triol as gene therapy drug for treating esophageal squamous cell carcinoma

A kind of technology of codonene and esophagus scale, applied in the field of medicine, can solve the problems such as patchoulenone that have not been disclosed

Pending Publication Date: 2018-11-30
淮安培元基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The prior art has not disclosed the relationship between patchoulenone, cyperacene, cyperene-2,5,8-triol and ESCC

Method used

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  • Use of cyperene-2,5,8-triol as gene therapy drug for treating esophageal squamous cell carcinoma
  • Use of cyperene-2,5,8-triol as gene therapy drug for treating esophageal squamous cell carcinoma
  • Use of cyperene-2,5,8-triol as gene therapy drug for treating esophageal squamous cell carcinoma

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Embodiment Construction

[0016] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0017] 1. Experimental materials

[0018] Esophageal squamous cell carcinoma TE-1 cells were purchased from ATCC; fetal bovine serum and DMEM medium were purchased from Gibco

[0019] Patchoulenone, Cyperone, Cyperene-2,5,8-triol are self-made, with a purity of over 95%.

[0020] 2. Experimental method

[0021] 1. Culture of esophageal squamous cell carcinoma TE-1

[0022] Routine resuscitation of esophageal squamous cell carcinoma TE-1, cultured in DMEM medium containing 10% fetal calf serum at 37°C, 5% CO 2 In the incubator, observe the cell growth. After 48 hours of culture, the medium was changed once, and thereafter, the medium was changed twice a week. After observing the cell growth to 70%-80% confluence, they were digested with trypsin and passaged at a ratio of 1:2...

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Abstract

The invention discloses a use of cyperene-2,5,8-triol as a gene therapy drug for treating esophageal squamous cell carcinoma. The invention finds out that cyperotundone and cypermethrin-2,5,8-triol are effective SIRT1 gene expression inhibitors, cyperotundone and cypermethrin-2,5,8-triol can effectively inhibit migration and invasion of esophageal squamous cell carcinoma by inhibiting the expression of an SIRT1 gene in esophageal squamous cell carcinoma, and can be developed as drugs for treating metastasis of esophageal squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of cyperazulene and cyperene-2,5,8-triol for preparing a medicine for inhibiting SIRT1 gene expression and treating esophageal squamous cell carcinoma. Background technique [0002] Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors of the digestive tract in my country. Although the diagnosis and treatment of esophageal cancer have been continuously improved in recent years, its overall survival has not been significantly improved, and its invasion and metastasis are still rare. One of the important reasons for the poor prognosis of esophageal cancer. [0003] Patchoulenone, cyperenone, and cyperene-2,5,8-triol are compounds present in sedge, and their chemical structures are as follows. [0004] [0005] The prior art has not disclosed the relationship between patchoulenone, cyperenone, cyperene-2,5,8-triol and ESCC. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61P35/04A61P35/00
CPCA61P35/00A61P35/04A61K31/047
Inventor 张长林杨佳
Owner 淮安培元基因科技有限公司
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