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Compounds for preventing and treating citrus canker and their applications

A citrus canker and compound technology, applied in the field of compounds for preventing and treating citrus canker, can solve problems such as food safety, ecological balance damage, and threats to human health, and achieve the effects of controlling transmission, reducing expression, and treating and preventing citrus canker

Active Publication Date: 2021-06-22
CHONGQING ACAD OF CHINESE MATERIA MEDICA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extensive use of these pesticides has brought about a series of problems such as environmental pollution, ecological balance damage and food safety, which seriously threaten human health.

Method used

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  • Compounds for preventing and treating citrus canker and their applications
  • Compounds for preventing and treating citrus canker and their applications
  • Compounds for preventing and treating citrus canker and their applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) DSF extraction separation method route

[0031] Ethyl acetate extraction (3 * 10 mL) RPFC mutation Xac [Xanthomonas Axonopodis Pv.citri, Xac)] Cultured supernatant, separated by semicchronchromatography, resulting in three active fractions Named EDSF, FDSF, GDSF, namely. FDSF and GDSF were further purified by G60 silica gel chromatography (eluent: n-hexane / ethyl acetate = 10 / 1), collecting fractions having ultraviolet fluorescence, specifically figure 1 Indicated.

[0032] The activity of three DSFs is monitored using the DSF sensor Fe58 after elution. The three active components are tested by HPLC under 210 nm. figure 2 ).

[0033] FDSF, the structure of GDSF passes ESI-MS, 1 H NMR, 13 C NMR, HMBC, HMQC, Cosy, etc. are characterized, Figure 3-14 Indicated. The chemical structure of the EDSF is:

[0034]

[0035] The chemical structure of FDSF is:

[0036]

[0037] The chemical structure of GDSF is:

[0038]

[0039] (2) DSF signal molecular activity detection

...

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Abstract

The invention provides a series of compounds for preventing and treating citrus canker, and its structural formula is: wherein, R1 is H + or CH 3 + One of them, R1 is H + or CH 3 + One of the compounds provided by the present invention can effectively interfere or antagonize the DSF population effect, reduce the expression of pathogenic factors, so as to control the spread of citrus canker and treat and prevent citrus canker.

Description

Technical field [0001] The present invention relates to a compound, and more particularly to compounds for preventing citrus ulcerosis and their applications. Background technique [0002] In 1991, Tang Ji Liang founded the DSF signal for the first time: the "8004" genotype "8004" genotype "8004" genotype is closely related, and any genetic mutation has significant affected extracellular enzyme and polysaccharide. Barber, etc., it is believed that the XCC wild type bacteria may secrete a small molecular signal, which can induce the production of the RPFF mutant to restore the production of extracellular proteases, and define this signal small molecule as DSF, and they think that DSF is small The fatty acid compound of the molecule. Slater et al. Created a stable, sensitive and convenient DSF detection method through a large experiment. In 2001, Zhang Hui was a chemical structure and biological function of DSF. In 2004, WANG et al. Was isolated from the supernatant of RPFC mutant ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C57/03A01N37/06A01P1/00
CPCA01N37/06C07C57/03
Inventor 刘晓玲谭春斌阳勇杜洪飞郭延垒常长青张炼辉
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA