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Fipronil self-nanoemulsion solution, and preparation method and application thereof

A technology of self-nanoemulsion and fiprenil, which is applied in the field of oil-in-water type non-pronil self-nanoemulsion solution and its preparation, can solve problems such as increased irritation and allergic reactions of animal skin, and achieve increased absorption rate, The preparation method is simple and convenient, and the effect of low surface tension

Inactive Publication Date: 2018-12-04
南京威特动物药品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the addition of organic solvents can easily lead to allergic reactions on animal skin, and the irritation increases

Method used

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  • Fipronil self-nanoemulsion solution, and preparation method and application thereof
  • Fipronil self-nanoemulsion solution, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of oil-in-water type fiprenil self-nanoemulsion solution, its percentage by weight is composed of feprenil 5g, jojoba oil (oily solvent) 25g, Tween-80 (emulsifier) ​​60g, n-butanol (assistant) emulsifier) ​​15g.

[0025] Preparation:

[0026] Get jojoba oil (oily solvent) 25g, Tween-80 (emulsifier) ​​60g, n-butanol (co-emulsifier) ​​15g and mix homogeneously, for subsequent use; The former medicine 5g of Fiprenil is mixed homogeneously with the obtained solution before, until The system is a transparent liquid, that is, a self-nanoemulsion solution of fipronina is obtained, and after further dilution with 10 times the mass of water, a colorless and transparent oil-in-water type non-pronil nanoemulsion solution can be obtained.

Embodiment 2

[0028] A kind of oil-in-water type Fiprenil self-nanoemulsion solution, its percentage by weight consists of Fiprenil 4.5g, ethyl oleate (oily solvent) 30g, polyoxyethylene ether castor oil (emulsifier) ​​55g, two Ethylene glycol monoethyl ether (co-emulsifier) ​​10.5g. Its preparation method refers to embodiment 1.

Embodiment 3

[0030] A kind of oil-in-water type fiprenil self-nanoemulsion solution, its percentage by weight is composed of feprenil 10g, coconut oil (oily solvent) 20g, OP-10 (emulsifier) ​​55g, 1,2-propanediol (assistant) emulsifier) ​​15g.

[0031] Its preparation method refers to embodiment 1.

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Abstract

The invention discloses a fipronil self-nanoemulsion solution, and a preparation method and an application thereof. The fipronil self-nanoemulsion solution is mainly prepared from, by weight, 1-20 parts of fipronil, 20-50 parts of an oily solvent, 40-80 parts of an emulsifier and 10-40 parts of a co-emulsifier. The oil-in-water fipronil nanoemulsion has the advantages of uniformity in distribution, good transparence and stability, low surface tension, good fluidity, convenience in use, narrow particle size distribution, small particle size, increase of the absorption rate of the effective component, and good in vitro permeability. The preparation method has the advantages of simplicity, convenience, and easiness in production and application; and the emulsion can be directly used in in-vitro parasite expelling of pets as a spray or a drop, and can be diluted with water to form the oil-in-water nanoemulsion having a small particle size, a good stability and a high pet skin permeabilityin order to expel in vitro parasites from the pets, and the above preparation is clinically used for treating the parasites of the pets.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to an oil-in-water type fiprenil self-nanoemulsion solution for expelling pet ectoparasites and a preparation method and application thereof. Background technique [0002] In recent years, the number of dogs and cats has increased, and the status of pets has become increasingly prominent. The treatment of diseases for dogs and cats has also received increasing attention. If domestic or domesticated dogs and cats are not properly managed and the sanitation conditions are poor, they are very susceptible to ectoparasitic diseases such as lice, fleas, and mites. According to the classification of pathogens, the ectoparasitic diseases that dogs and cats are susceptible to can be divided into three categories: lice, fleas, and acariasis. [0003] Lice can cause depression and weakness in dogs and cats; fleas are a very common external parasite in dogs and cats, and fleas in dogs and ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/08A61K31/415A61K47/44A61K47/22A61K47/14A61P33/14
CPCA61K9/0014A61K9/08A61K9/1075A61K31/415A61K47/14A61K47/22A61K47/44A61P33/14
Inventor 潘达庄焕泉胡桂敏
Owner 南京威特动物药品有限公司
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