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New preparation method of 3-methoxy-beta-nitrostyrene

A technology of nitrostyrene and methoxybenzaldehyde, which is applied in the field of medicine and can solve problems such as low yield, complex synthesis process, and unstable yield

Inactive Publication Date: 2018-12-04
SHANGHAI HUAJIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The yield of the existing 3-methoxy-β-nitrostyrene preparation method is not high, the synthesis process is complicated, and the yield is unstable. It is necessary to invent a new preparation method to overcome the deficiencies of the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: Preparation of 3-methoxy-β-nitrostyrene:

[0008] Add 1362 mg of 3-methoxybenzaldehyde in the reactor, add 30 ml of methanol, stir, add 671 mg of nitromethane at room temperature, then stir in an ice bath for 20 minutes, then add 848 mg of ammonium acetate, and then After stirring for 4 hours, the reaction solution gradually turned yellow. After standing for 5 hours, the yellow solid was filtered off. Then recrystallize in methanol, filter and dry in vacuum to obtain the compound 3-methoxy-β-nitrostyrene with a yield of 90.2%.

Embodiment 2

[0009] Embodiment 2: Preparation of 3-methoxy-β-nitrostyrene:

[0010] Add 1362 mg of 3-methoxybenzaldehyde in the reactor, add 30 ml of methanol, stir, add 671 mg of nitromethane at room temperature, then stir in an ice bath for 20 minutes, then add 848 mg of ammonium acetate, and then After stirring for 4 hours, the reaction solution gradually turned yellow. After standing for 5 hours, the yellow solid was filtered off. Then recrystallize in methanol, filter and dry in vacuum to obtain compound 3-methoxy-β-nitrostyrene with a yield of 87.7%.

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PUM

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Abstract

The invention relates to a new preparation method of 3-methoxy-beta-nitrostyrene, and belongs to the technical field of medicine technologies. A technical problem to be solved in the invention is to provide the advanced new preparation method of 3-methoxy-beta-nitrostyrene. The point of a technical scheme for solving the technical problem is the new preparation method of the compound.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to a new preparation method of 3-methoxy-β-nitrostyrene. Background technique [0002] 3-Methoxy-β-nitrostyrene is an important intermediate raw material for the synthesis of pharmaceutical products. [0003] The yield of the existing 3-methoxy-β-nitrostyrene is not high, the synthesis process is complicated, and the yield is unstable. It is necessary to invent a new preparation method to overcome the shortcomings of the prior art. Contents of the invention [0004] The present invention adopts a new technology, aiming at the disadvantages of the existing 3-methoxy-β-nitrostyrene preparation method that the yield is not high, the synthesis process is complicated, the yield is unstable, and the purchase cost of the required raw materials is high. , after long-term research and development, a new preparation method was invented to overcome the shortcomings o...

Claims

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Application Information

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IPC IPC(8): C07C201/12C07C205/32
CPCC07C201/12C07C205/32
Inventor 不公告发明人
Owner SHANGHAI HUAJIN BIOTECH CO LTD