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Preparation method of double-layer compound bletilla striata-based dressing

A double-layer compound, bletilla striata-based technology, applied in the field of biomedicine, can solve the problems of not being able to adhere well to the wound, limiting the application range of the dressing, unfavorable dressing application, etc., to achieve rapid healing, soft texture, and excellent mechanical properties Effect

Inactive Publication Date: 2018-12-07
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because the bletilla striata polysaccharide is very soluble in water, it is easy to adhere and difficult to detach during operation, so it cannot be well attached to the wound during use.
[0004] The existing Bletilla striata dressing will dissolve and stick because of the blood on the gloves worn by doctors during surgical operations, which is not conducive to the application of the dressing on the wound
The operating layer of traditional multi-layer dressings is non-degradable, which greatly limits the application range of dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] A kind of preparation method of double-layer composite bletilla striata-based dressing, described preparation method is carried out according to the following steps:

[0027] a Bletilla striata polysaccharide extraction

[0028] Soak dried bletilla striata stems and distilled water at a mass ratio of 1:3 to 1:10 for 3 to 20 minutes at a temperature of 25 to 40°C, filter through gauze to remove soluble and insoluble impurities , collect the initially cleaned stems of Bletilla striata and dry them in an oven at 30-50°C for 18-24 hours.

[0029] Soak the stems of Bletilla striata after preliminary cleaning and drying with absolute ethanol at a mass ratio of 1:3 to 1:10 for 1 to 3 hours at a soaking temperature of 20 to 30°C, filter through gauze to remove soluble pigments, Collect the stems of Bletilla striata and dry them in an oven at 30-50°C for 18-24 hours.

[0030] Take the depigmented Bletilla striata stem and soak it in distilled water at a mass ratio of 1:3 to 1:...

Embodiment 1

[0040] a Bletilla striata polysaccharide extraction

[0041] Soak the dried stems of Bletilla striata with distilled water at a mass ratio of 1:5 for 15 minutes at a temperature of 30°C, filter through gauze to remove soluble and insoluble impurities, and collect initially cleaned stems of Bletilla striata at 50°C Oven dry for 19h.

[0042] Soak the stems of Bletilla striata after preliminary cleaning and drying with absolute ethanol at a mass ratio of 1:3 for 3 hours, soaking temperature at 25°C, filter through gauze to remove soluble pigments, collect stems of Bletilla striata in an oven at 30°C Dry for 23h.

[0043] The depigmented Bletilla striata stems were soaked in distilled water at a mass ratio of 1:5 for 1 hour at a soaking temperature of 80°C, filtered through gauze, and the Bletilla striata polysaccharide filtrate was collected.

[0044] The bletilla striata stem block after extracting the bletilla striata polysaccharide filtrate continued to soak and filter the ...

Embodiment 2

[0052] a Bletilla striata polysaccharide extraction

[0053] Soak the dried stems of Bletilla striata with distilled water at a mass ratio of 1:3, soak for 20 minutes, soak at a temperature of 35°C, filter through gauze to remove soluble and insoluble impurities, and collect initially cleaned stems of Bletilla striata at 35°C Oven dry for 20h.

[0054] Soak the stems of Bletilla striata after preliminary cleaning and drying with absolute ethanol at a mass ratio of 1:4 for 2.5 hours, soaking temperature at 25°C, filter through gauze to remove soluble pigments, and collect stems of Bletilla striata at 45°C Oven dry for 19h.

[0055] The depigmented Bletilla striata stems were soaked in distilled water at a mass ratio of 1:5 for 1 hour at a soaking temperature of 90°C, filtered through gauze, and the Bletilla striata polysaccharide filtrate was collected.

[0056] Continue the soaking and filtering process of extracting the Bletilla striata polysaccharide filtrate from the blet...

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Abstract

The invention relates to a preparation method of a double-layer compound bletilla striata-based dressing, belonging to the technical field of biomedicines. The preparation method comprises the following steps: paving a layer of water-insoluble gelatin sponge medical oxidized cellulose gauze on the surface layer of of the prepared bletilla striata polysaccharide film casting solution a certain concentration, freezing the two into a double-layer film by using a freezing method, and then performing freeze-drying method to obtain the double-layer compound bletilla striata-based dressing, thus effectively solving the problems that the existing bletilla striata-based dressing is soluble in water and difficult to be attached to a wound in clinical medical use. The preparation method is simple intechnology and low in cost, and the two layers of dressings are firmly combined by utilizing mutual penetration and locking of holes between two layers, so that enough mechanical strength in use can be guaranteed. The materials adopted in the preparation method can be degraded and absorbed, thus having no toxicity to a human body.

Description

technical field [0001] The invention relates to a preparation method of a double-layer composite bletilla striata-based dressing, which belongs to the technical field of biomedicine. Background technique [0002] In the clinical use of surgery, the rapid hemostasis of the wound has an important impact on the postoperative recovery of patients. Bletilla striata polysaccharide has the functions of antibacterial and anti-inflammatory, removing putrefaction and promoting granulation, astringent sores, etc., and has no toxic and side effects, is safe and comfortable, degradable, non-polluting, and has good biocompatibility. It is a good natural bioengineering material and can be used as a drug dressing in pharmaceutical preparations. [0003] The Chinese patent publication number is CN102477102A, the publication date is May 12, 2012, and the title of the invention is a method for using bletilla striata polysaccharides as a hemostatic material. The invention uses bletilla striata...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61L15/62
CPCA61L15/32A61L15/28A61L15/42A61L15/425A61L15/44A61L15/46A61L15/62A61L2300/232A61L2300/404A61L2300/41A61L2300/412A61L2400/04C08L89/00C08L1/04
Inventor 杨红军王晗李美辰翁雅雪张骞付专陈欣庄燕徐卫林
Owner WUHAN TEXTILE UNIV
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